18 . August , 2018 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Norethindrone Acetate

Big Image Pronouncation: (nor-eth-IN-drone ASS-uh-TATE)
Class: Progestin

Trade Names:
Aygestin
- Tablets 5 mg

Norlutate (Canada)

Mechanism of Action

Pharmacology

Inhibits secretion of pituitary gonadotropins, thereby preventing follicular maturation and ovulation.

Pharmacokinetics

Absorption

Norethindrone acetate is rapidly absorbed from GI tract. T max is approximately 2 hr.

Distribution

Rapid distribution of dorethindrone acetate.

Metabolism

Norethindrone is metabolized in the liver.

Elimination

Norethindrone elimination is rapid, primarily in feces.

Indications and Usage

Treatment of secondary amenorrhea; endometriosis; abnormal uterine bleeding caused by hormonal imbalance in the absence of organic pathology (eg, uterine cancer).

Contraindications

Thrombophlebitis, thrombolic disorders, cerebral apoplexy, or a history of these conditions; markedly impaired liver function or liver disease; known or suspected carcinoma of the breast; undiagnosed vaginal bleeding; missed abortion; as a diagnostic test for pregnancy.

Dosage and Administration

Secondary Amenorrhea, Abnormal Uterine Bleeding
Adults

PO 2.5 to 10 mg/day for 5 to 10 days during second half of the theoretical menstrual cycle.

Endometriosis
Adults

PO 5 mg/day initially for 2 wk, then increase in increments of 2.5 mg/day q 2 wk until 15 mg/day is achieved. Therapy may be continued at this level for 6 to 9 mo or until breakthrough bleeding demands temporary termination.

General Advice

  • Administer once daily, without regard to meals. Administer with food if GI upset occurs.

Storage/Stability

Store at controlled room temperature (59° to 86°F).

Drug Interactions

Rifampin

Elimination of norethindrone may be increased, decreasing the therapeutic effect.

Laboratory Test Interactions

Pregnanediol determinations may be altered; thyroid and LFT results may be affected; increased amounts of coagulation factors; reduced response to metyrapone test.

Adverse Reactions

Cardiovascular

Thrombophlebitis; cerebral thrombosis and embolism; hypertension; edema.

CNS

Depression; changes in libido; changes in appetite; headache; nervousness; dizziness; fatigue.

Dermatologic

Allergic rash; melasma; chloasma; hirsutism; alopecia; erythema multiforme; erythema nodosum; hemorrhagic eruption; itching.

EENT

Neuro-ocular lesions (eg, retinal thrombosis, optic neuritis).

Genitourinary

Breakthrough bleeding; spotting; amenorrhea; increased cervical erosion and secretion; cystitis.

Hepatic

Cholestatic jaundice.

Metabolic

Weight gain and loss.

Respiratory

Pulmonary embolism.

Miscellaneous

Premenstrual syndrome; backache.

Precautions

Pregnancy

Category X .

Lactation

Excreted in breast milk.

Children

Safety and efficacy not established.

Fluid retention

Use with careful observation when conditions that might be affected by fluid retention are present (eg, asthma, cardiac or renal dysfunction, epilepsy).

Mental depression

Carefully observe patients with history of depression.

Ophthalmic effects

Discontinue therapy if there are any sudden changes in vision or onset of proptosis, diplopia, migraine, papilledema, or retinal vascular lesions.

Patient Information

  • Explain name, dose, action and potential side effects of drug.
  • Instruct patient to take once daily as prescribed.
  • Advise patient that medication can be taken without regard to meals, but to take with food if GI upset occurs.
  • Warn women of childbearing potential of significant risks associated with taking this medication and becoming pregnant.
  • Instruct diabetic patient to monitor blood glucose more frequently when drug is started or dose is changed and to inform health care provider of significant changes in readings.
  • Instruct patient to report the following symptoms to health care provider: pain in groin or calves; sharp chest pain or sudden shortness of breath; abnormal vaginal bleeding; sudden severe headache or migraine headache; vision problems; yellowing of skin or eyes; or depression.
  • Instruct women to notify health care provider if becoming pregnant, planning to become pregnant, or are breastfeeding.
  • Instruct patient to not take any prescription or OTC medications or dietary supplements unless advised to do so by the health care provider.
  • Advise patient that follow-up visits and examinations may be required to monitor therapy and to be sure to keep appointments.

Recent Drug Updates at DrugIndexOnline:





Deconamine Deconamine
Some commonly used brand names are: In the U.S.— Allerest Maximum Strength 7 Allerphed 14 Atrohist Pediatric 7 Atrohist Pediatric Suspension Dye Free 8 Benadryl Allergy Decongestant Liquid Medication 10 Brofed Liquid 3 Bromadrine TR 3 Bromfed 3 Bromfed-PD 3 Bromfenex 3 Bromfenex PD 3 Chlo more...

Etrafon Etrafon
Some commonly used brand names are: In the U.S.— Etrafon Etrafon-A Etrafon-Forte Triavil In Canada— Elavil Plus Etrafon Etrafon-A Etrafon-D Etrafon-F PMS Levazine Triavil Generic name product may be available in the U.S. Category Antipsychotic-antidepressant Description P more...

Histamine Histamine
* Not commercially available in the U.S. Category Diagnostic aid, gastric function Description Histamine (HISS-ta-meen) is used to help diagnose problems or disease of the stomach. This test determines how much acid your stomach produces. How the stomach test is done: Before this medicine i more...

Hytone Lotion Hytone Lotion
Generic Name: Hydrocortisone Lotion (hye-droe-KOR-ti-sone) Brand Name: Examples include Hytone and NutracortHytone Lotion is used for:Reducing itching, redness, and swelling associated with many skin conditions. Hytone Lotion is a topical corticosteroid. It works by depressing the formation, re more...

Mediplast Topical Mediplast Topical
Some commonly used brand names are: In the U.S.— Antinea Buf-Puf Acne Cleansing Bar with Vitamin E Calicylic Creme Clearasil Clearstick Maximum Strength Topical Solution Clearasil Clearstick Regular Strength Topical Solution Clearasil Double Textured Pads Maximum Strength Clearasil Double more...

Navane Navane
Generic name: Thiothixene Brand names: Navane Why is Navane prescribed? Navane is used in the treatment of schizophrenia (a disruption of thought and the understanding of reality). Researchers theorize that antipsychotic medications such as Navane work by lowering levels of dopamine, a neurotran more...

Paplex Ultra Topical Paplex Ultra Topical
Some commonly used brand names are: In the U.S.— Antinea Buf-Puf Acne Cleansing Bar with Vitamin E Calicylic Creme Clearasil Clearstick Maximum Strength Topical Solution Clearasil Clearstick Regular Strength Topical Solution Clearasil Double Textured Pads Maximum Strength Clearasil Double more...

Pentrax Anti-Dandruff Tar Shampoo Topical Pentrax Anti-Dandruff Tar Shampoo Topical
Some commonly used brand names are: In the U.S.— Alphosyl Aquatar Balnetar Therapeutic Tar Bath Cutar Water Dispersible Emollient Tar Denorex Extra Strength Medicated Shampoo Denorex Extra Strength Medicated Shampoo with Conditioners Denorex Medicated Shampoo Denorex Medicated Shampoo and more...