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All about: Numorphan

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Generic Name: Oxymorphone Injection (ox-ee-MOR-fone)
Brand Name: Numorphan

Numorphan is used for:

Treating moderate to severe pain. It may be used before surgery to cause sedation and reduce anxiety. It may also be used for other conditions as determined by your doctor.

Numorphan is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, respiratory and circulatory systems) at higher doses.

Do NOT use Numorphan if:

  • you are allergic to any ingredient in Numorphan or any other oxymorphone- or morphine-related medicine (eg, codeine)
  • you are taking sodium oxybate (GHB)
  • you have severe bowel motility problems (eg, paralytic ileus) or severe diarrhea associated with antibiotic use (pseudomembranous colitis)
  • you have severely slow or difficult breathing, fluid in the lungs due to chemical irritation, or severe asthma, or you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Numorphan :

Some medical conditions may interact with Numorphan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines or other substances
  • if you have a history of asthma, chronic obstructive pulmonary disease (COPD), trouble breathing while asleep (eg, sleep apnea), or other lung or breathing problems
  • if you have a history of recent head injury, increased pressure in the brain, growths in the brain (eg, tumors), or seizures
  • if you have a history of heart problems, low blood pressure, liver or kidney problems, underactive thyroid, adrenal gland problems (eg, Addison disease), increased pressure in the eye, glaucoma, stomach or bowel problems, gallbladder problems, inflammation of the pancreas, a blockage of the bladder or bowel, an enlarged prostate, or the blood disease porphyria
  • if you have a history of drug or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Numorphan . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cimetidine, furazolidone, monoamine oxidase (MAO) inhibitors (eg, phenelzine), phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects such as severe drowsiness, slow or difficult breathing, confusion, and seizures may be increased
  • Buprenorphine, butorphanol, nalbuphine, naltrexone, or pentazocine because the effectiveness of Numorphan may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Numorphan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Numorphan :

Use Numorphan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Numorphan is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Numorphan at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Numorphan contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • If you miss a dose of Numorphan and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Numorphan .

Important safety information:

  • Numorphan may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Numorphan . Using Numorphan alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Numorphan . This medicine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Numorphan may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Numorphan .
  • Use Numorphan with caution in the ELDERLY because they may be more sensitive to its effects.
  • Use Numorphan with extreme caution in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Numorphan , discuss with your doctor the benefits and risks of using Numorphan during pregnancy. It is unknown if Numorphan is excreted in breast milk. If you are or will be breast-feeding while you are using Numorphan , check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, Numorphan may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Numorphan stops working well. Do not take more than prescribed.

When used for long periods of time or at high doses, some people develop a need to continue taking Numorphan . This is known as DEPENDENCE or addiction.

If you suddenly stop taking Numorphan , you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; hallucinations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Numorphan :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; nausea; sleeplessness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating; fast or slow heartbeat; seizures; severe dizziness, lightheadedness, or fainting; slowed or difficult breathing; stomach pain; tremor; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include cold and clammy skin; confusion; loss of consciousness; seizures; severe drowsiness, dizziness, or lightheadedness; slow breathing; slow heartbeat.

Proper storage of Numorphan :

Store Numorphan at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in the bathroom. Keep Numorphan out of the reach of children and away from pets.

General information:

  • If you have any questions about Numorphan , please talk with your doctor, pharmacist, or other health care provider.
  • Numorphan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Numorphan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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