20 . September , 2018 - Thursday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Oxycodone/Acetaminophen

Big Image Pronouncation: (OX-ee-KOE-dohn/ass-cet-ah-MEE-noe-fen)
Class: Opioid analgesic combination

Trade Names:
- Tablets 5 mg oxycodone HCl/325 mg acetaminophen
- Tablets 7.5 mg oxycodone HCl/500 mg acetaminophen
- Tablets 10 mg oxycodone HCl/650 mg acetaminophen

Trade Names:
- Tablets 5 mg oxycodone HCl/325 mg acetaminophen
- Solution, oral 5 mg oxycodone HCl/325 mg acetaminophen

Trade Names:
Roxicet 5/500
- Caplets 5 mg oxycodone/500 mg acetaminophen

Trade Names:
- Capsules 5 mg oxycodone HCl/500 mg acetaminophen

Trade Names:
- Capsules 5 mg oxycodone HCl/500 mg acetaminophen

Percocet-Demi (Canada)
ratio-Oxycocet (Canada)

Mechanism of Action


Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.

Indications and Usage

Relief of moderate to moderately severe pain.


Hypersensitivity to acetaminophen, oxycodone, or similar compounds.

Dosage and Administration


PO 5 mg (1 tablet, caplet, or teaspoonful) q 6 hr prn.


Store at room temperature (59° to 86°F).

Drug Interactions


Additive CNS depression.

Carbamazepine, hydantoins, sulfinpyrazone

Increased risk of hepatotoxicity.

CNS depressants (eg, barbiturates, tricyclic antidepressants, phenothiazines, sedatives, hypnotics, alcohol, other narcotics)

Additive CNS depression.

Laboratory Test Interactions

With Chemstrip bG , Dextrostix , and Visidex II home blood glucose systems, may cause false decrease in mean glucose values.

Adverse Reactions


Hypotension; bradycardia; tachycardia.


Lightheadedness; dizziness; weakness; fatigue; sedation; euphoria; dysphoria; nervousness; headache; confusion.


Pruritus; rash.


Nausea; vomiting; constipation; abdominal pain; anorexia; biliary spasm; dry mouth.


Urinary retention or hesitancy.


Dyspnea; respiratory depression.


Malaise; tolerance; psychological and physical dependence with chronic use.



Category C .




Safety and efficacy not established.

Hepatic Function

Chronic alcoholics should limit acetaminophen intake to less than 2 g/day.

Special Risk Patients

Use with caution in elderly, debilitated patients and those with hepatic or kidney failure or conditions accompanied by hypoxia or hypercapnia; monitor carefully to avoid decrease in pulmonary ventilation. Also use cautiously in patients sensitive to CNS depressants, postoperatively and in patients with pulmonary disease.

Sulfite Sensitivity

Use with caution in patients known to be sensitive, as some products contain bisulfites.

Acute abdominal conditions

Diagnosis may be obscured; use with caution.


Can produce drug dependence; has abuse potential.

Head injury

Respiratory depression and elevation of CSF pressure may be exacerbated.



Miosis, respiratory depression, CNS depression (somnolence progressing to stupor or coma), hepatic damage, circulatory collapse, cardiopulmonary arrest, death.

Patient Information

  • Instruct patient to take medication before pain becomes severe for greatest effectiveness.
  • Teach patient methods to prevent constipation.
  • Instruct patient to make position changes slowly if lightheadedness or sedation occurs.
  • Advise patient to avoid intake of alcoholic beverages or products containing alcohol while using this medication.
  • Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
  • Caution patient that physical dependency and withdrawal symptoms may occur following discontinuation of long-term therapy.
  • Instruct patient not to take any otc medications without consulting health care provider.

Recent Drug Updates at DrugIndexOnline:

Ciprofloxacin Hydrochloride/Hydrocortisone Ciprofloxacin Hydrochloride/Hydrocortisone
Pronouncation: (Sip-ROW-FLOX-uh-sin HIGH-droe-KLOR-ide/HIGH-droe-core-tih-sone) Class: Steroid and antibiotic combination Trade Names: Cipro HC Otic - Suspension 2 mg ciprofloxacin, 10 mg hydrocortisone/mL Mechanism of Action Pharmacology Ciprofloxacin Interferes with microbial DNA synthesis. Hydro more...

Cistobil Diagnostic Cistobil Diagnostic
Some commonly used brand names are: In the U.S.— Bilivist 3 Bilopaque 4 Cholebrine 1 Oragrafin Calcium 3 Oragrafin Sodium 3 Telepaque 2 In Canada— Telepaque 2 Biloptin 3 Cistobil 2 Colebrin 1 Colebrina 1 Colegraf 2 Felombrine 2 Jopanonsyre 2 Lumopaque 4 Neocontrast 2 Another co more...

CodiCLEAR DH Liquid CodiCLEAR DH Liquid
Generic Name: Guaifenesin/Hydrocodone Liquid and Syrup (gwye-FEN-e-sin/hye-droe-KOE-done) Brand Name: Examples include CodiCLEAR DH and Maxi-Tuss HCGCodiCLEAR DH Liquid is used for:Relieving cough and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other co more...

Deconamine Deconamine
Generic name: Chlorpheniramine maleate, d-Pseudoephedrine hydrochloride Brand names: Deconamine Why is Deconamine prescribed? Deconamine is an antihistamine and decongestant used for the temporary relief of persistent runny nose, sneezing, and nasal congestion caused by upper respiratory infecti more...

Dimetapp Allergy Sinus Dimetapp Allergy Sinus
Generic Name: acetaminophen/brompheniramine/phenylpropanolamine (a see ta MIH noe fen/brome feh NEER a meen/fen ill proe pa NOLE a meen) Brand Names: Dimetapp Allergy Sinus, Dimetapp Cold and Flu What is Dimetapp Allergy Sinus (acetaminophen/brompheniramine/phenylpropanolamine)? Acetami more...

Imitrex Nasal oral/nasal Imitrex Nasal oral/nasal
Generic Name: sumatriptan (oral/nasal) (soo ma TRIP tan) Brand Names: Imitrex, Imitrex Nasal What is sumatriptan? Sumatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger more...

Indium In 111 Pentetreotide Diagnostic Indium In 111 Pentetreotide Diagnostic
This information applies to the following medicines when used for diagnosis: 1. Ammonia N 13 (a-MOE-nya) 2. Cyanocobalamin Co 57 (sye-an-oh-koe-BAL-a-min) 3. Ferrous Citrate Fe 59 (FER-us SI-trate) 4. Fludeoxyglucose F 18 (flu-dee-ox-ee-GLOO-kose) 5. Gallium Citrate Ga 67 (GAL-ee-um) more...

Isoproterenol Isoproterenol
Some commonly used brand names are: In the U.S.— Adrenalin Chloride 3 Airet 1 Alupent 8 Arm-a-Med Isoetharine 6 Arm-a-Med Metaproterenol 8 Asthmahaler Mist 3 AsthmaNefrin 3 Beta-2 6 Brethaire 12 Bronkaid Mist 3 Bronkaid Suspension Mist 3 Bronkometer 6 Bronkosol 6 Dey-Lute Isoetharine 6 De more...