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All about: Oxycodone/Acetaminophen

Big Image Pronouncation: (OX-ee-KOE-dohn/ass-cet-ah-MEE-noe-fen)
Class: Opioid analgesic combination

Trade Names:
- Tablets 5 mg oxycodone HCl/325 mg acetaminophen
- Tablets 7.5 mg oxycodone HCl/500 mg acetaminophen
- Tablets 10 mg oxycodone HCl/650 mg acetaminophen

Trade Names:
- Tablets 5 mg oxycodone HCl/325 mg acetaminophen
- Solution, oral 5 mg oxycodone HCl/325 mg acetaminophen

Trade Names:
Roxicet 5/500
- Caplets 5 mg oxycodone/500 mg acetaminophen

Trade Names:
- Capsules 5 mg oxycodone HCl/500 mg acetaminophen

Trade Names:
- Capsules 5 mg oxycodone HCl/500 mg acetaminophen

Percocet-Demi (Canada)
ratio-Oxycocet (Canada)

Mechanism of Action


Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.

Indications and Usage

Relief of moderate to moderately severe pain.


Hypersensitivity to acetaminophen, oxycodone, or similar compounds.

Dosage and Administration


PO 5 mg (1 tablet, caplet, or teaspoonful) q 6 hr prn.


Store at room temperature (59° to 86°F).

Drug Interactions


Additive CNS depression.

Carbamazepine, hydantoins, sulfinpyrazone

Increased risk of hepatotoxicity.

CNS depressants (eg, barbiturates, tricyclic antidepressants, phenothiazines, sedatives, hypnotics, alcohol, other narcotics)

Additive CNS depression.

Laboratory Test Interactions

With Chemstrip bG , Dextrostix , and Visidex II home blood glucose systems, may cause false decrease in mean glucose values.

Adverse Reactions


Hypotension; bradycardia; tachycardia.


Lightheadedness; dizziness; weakness; fatigue; sedation; euphoria; dysphoria; nervousness; headache; confusion.


Pruritus; rash.


Nausea; vomiting; constipation; abdominal pain; anorexia; biliary spasm; dry mouth.


Urinary retention or hesitancy.


Dyspnea; respiratory depression.


Malaise; tolerance; psychological and physical dependence with chronic use.



Category C .




Safety and efficacy not established.

Hepatic Function

Chronic alcoholics should limit acetaminophen intake to less than 2 g/day.

Special Risk Patients

Use with caution in elderly, debilitated patients and those with hepatic or kidney failure or conditions accompanied by hypoxia or hypercapnia; monitor carefully to avoid decrease in pulmonary ventilation. Also use cautiously in patients sensitive to CNS depressants, postoperatively and in patients with pulmonary disease.

Sulfite Sensitivity

Use with caution in patients known to be sensitive, as some products contain bisulfites.

Acute abdominal conditions

Diagnosis may be obscured; use with caution.


Can produce drug dependence; has abuse potential.

Head injury

Respiratory depression and elevation of CSF pressure may be exacerbated.



Miosis, respiratory depression, CNS depression (somnolence progressing to stupor or coma), hepatic damage, circulatory collapse, cardiopulmonary arrest, death.

Patient Information

  • Instruct patient to take medication before pain becomes severe for greatest effectiveness.
  • Teach patient methods to prevent constipation.
  • Instruct patient to make position changes slowly if lightheadedness or sedation occurs.
  • Advise patient to avoid intake of alcoholic beverages or products containing alcohol while using this medication.
  • Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
  • Caution patient that physical dependency and withdrawal symptoms may occur following discontinuation of long-term therapy.
  • Instruct patient not to take any otc medications without consulting health care provider.

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