15 . November , 2018 - Thursday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Palifermin

Big Image Pronouncation: (pal-ee-FER-min)
Class: Keratinocyte growth factor

Trade Names:
- Powder for injection, lyophilized 6.25 mg

Mechanism of Action


Binding of keratinocyte growth factor may result in proliferation, differentiation, and migration of epithelial cells.



Shows linear pharmacokinetics and has extravascular distribution. Steady-state Vd appears to be 2-fold higher in cancer patients compared with healthy volunteers.


Total body clearance appears to be 2- to 4-fold higher in cancer patients compared with healthy volunteers. Elimination t ½ is 3.3 to 5.7 hr.

Indications and Usage

Decrease incidence and duration of severe oral mucositis in patients with hematologic malignancies receiving myelotoxic therapy requiring hematopoietic stem cell support.


Hypersensitivity to Escherichia coli -derived proteins, or any component of the product.

Dosage and Administration

Premyelotoxic Therapy

IV Three 60 mcg/kg/day doses administered prior to myelotoxic therapy, with third dose 24 to 48 hr before myelotoxic therapy.

Postmyelotoxic Therapy

IV Three 60 mcg/kg/day doses administered after myelotoxic therapy, with the first of these doses given after, but on the same day of hematopoietic stem cell infusion and at least 4 days after the most recent administration of palifermin.

General Advice

  • For IV bolus injection only. Not for intradermal, subcutaneous, IM, continuous or intermittent IV infusion, or intra-arterial administration.
  • Dose is administered once daily for 3 consecutive days before and 3 consecutive days after myelotoxic therapy, for a total of 6 doses.
  • Do not administer palifermin within 24 hr before, during infusion of, or within 24 hr after administration of myelotoxic chemotherapy.
  • Reconstitute powder for injection by slowly injecting 1.2 mL sterile water for injection into vial. Gently swirl contents to dissolve (should take less than 3 min). Do not shake or vigorously agitate vial. Reconstituted solution provides 5 mg palifermin/mL.
  • Do not administer if solution is cloudy, discolored, or contains particulate matter.
  • Administer prescribed dose by IV bolus injection. If heparin is used to maintain IV line, use saline to flush line prior to and after palifermin administration because palifermin binds to heparin.
  • Do not filter reconstituted solution during preparation or administration.


  • Reconstituted solution contains no preservatives and should be administered immediately. If not administered immediately, reconstituted solution may be stored in its carton in refrigerator (36° to 46°F) for up to 24 hr. Do not freeze reconstituted solution. Prior to injection, refrigerated reconstituted solution may be allowed to reach room temperature for a maximum of 1 hr while protecting solution from exposure to light. Discard any solution left at room temperature for more than 1 hr.
  • Vials contain no preservative. Discard any unused portion of reconstituted solution. Do not combine unused portions.
  • Store unopened vials in carton in refrigerator (36° to 46°F). Protect from light. Keep vials in pack until time of use.

Drug Interactions


Because administration of palifermin within 24 hr of chemotherapy has resulted in increased severity and duration of oral mucositis, do not give palifermin within 24 hr before, during infusion, or within 24 hr after myelotoxic chemotherapy.


Because palifermin binds to heparin in vitro, if heparin is used to maintain an IV line, rinse the line with saline prior to and after palifermin administration.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Hypertension (7%).


Dysesthesia (hyperesthesia, hypoesthesia, paresthesia) (12%).


Rash (62%); pruritus (35%); erythema (32%).


Mouth/tongue thickness or discoloration (17%); altered taste (16%).

Lab Tests

Elevated serum amylase (62%, grade 3/4 [38%]); elevated serum lipase (28%; grade 3/4 [11%]).


Arthralgia (10%).


Fever (39%); edema (28%); pain (16%).



Category C .




Safety and efficacy not established.

Patient Information

  • Explain name, dose, action, potential side effects, and potential risks, including potential for stimulation of tumor growth if used in patient with nonhematologic malignancy.
  • Advise patient that medication will be prepared and administered by a health care professional in a health care setting.
  • Advise patient that medication may cause skin or mucus membrane side effects (eg, rash, redness, edema, itching, abnormal skin sensations around the mouth, tongue discoloration, tongue thickening, taste alteration) and to report these side effects, or any others, to health care professional.

Recent Drug Updates at DrugIndexOnline:

Ambien Ambien
Generic Name: zolpidem tartrate Dosage Form: Tablets civ Ambien Description Ambien (zolpidem tartrate), is a non-benzodiazepine hypnotic of the imidazopyridine class and is available in 5-mg and 10-mg strength tablets for oral administration. Chemically, zolpidem is N,N,6-trimethyl-2-p-tolylimida more...

Amin-Aid Amin-Aid
Some commonly used brand names are: In the U.S.— Accupep HPF 9 Advera 2 Alitraq 9 Amin-Aid 2 Attain 10 Carnation Instant Breakfast 7 Carnation Instant Breakfast No Sugar Added 7 Casec 8 CitriSource 10 Compleat Modified 1 Compleat Regular 1 Comply 10 Criticare HN 9 Crucial 2 Deliver 2.0 10 more...

Chlorpropamide Chlorpropamide
Generic name: Chlorpropamide Brand names: Diabinese Why is Chlorpropamide prescribed? Diabinese is an oral antidiabetic medication used to treat type 2 (non-insulin-dependent) diabetes. Diabetes occurs when the body fails to produce enough insulin or is unable to use it properly. Insulin is beli more...

Glyburide and Metformin Glyburide and Metformin
Generic Name: Glyburide and Metformin Hydrochloride Dosage Form: Tablets Glyburide and Metformin Description Glyburide and Metformin hydrochloride tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes, Glyburide and Metformin hydrochloride. Glyburide is an ora more...

Iletin II NPH Pork Iletin II NPH Pork
Generic Name: insulin isophane (IN suh lin EYE sew fane) Brand Names: Humulin N, Humulin N Pen, Iletin II NPH Pork, Insulin Purified NPH Pork, Novolin N, Novolin N Innolet, Novolin N PenFill What is Iletin II NPH Pork (insulin isophane)? Insulin is a hormone naturally produced by the pa more...

Magnesium Sulfate Magnesium Sulfate
Pronouncation: (mag-NEE-zee-uhm SULL-fate) Class: Anticonvulsant Trade Names: Epsom Salt - Granules see care instructions Trade Names: Magnesium sulfate - Injection 4% (0.325 mEq/mL) - Injection 8% (0.65 mEq/mL) - Injection 12.5% (1 mEq/mL) - Injection 50% (4 mEq/mL) Mechanism of Action Pharmacolog more...

Norditropin Norditropin
Generic Name: somatropin (soe ma TROE pin) Brand Names: Genotropin, Humatrope, Norditropin, Nutropin, Saizen, Serostim, Zorbtive What is Norditropin (somatropin)? Somatropin is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and musc more...

Ocuflox Ocuflox
Generic Name: ofloxacin Dosage Form: Ophthalmic solution Ocuflox Description Ocuflox® (ofloxacin ophthalmic solution) 0.3% is a sterile ophthalmic solution. It is a fluorinated carboxyquinolone anti-infective for topical ophthalmic use. Chemical Name: (±)-9-Fluoro-2, 3-dihydro-3-methy more...