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All about: Phenergan Suppositories

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Generic Name: Promethazine Suppositories (proe-METH-a-zeen)
Brand Name: Phenergan

Phenergan Suppositories should not be used in children younger than 2 years old. Potentially fatal side effects (eg, difficult or slowed breathing, drowsiness leading to coma) may occur in this age group when taking Phenergan Suppositories.

Caution should be used when using Phenergan Suppositories in children 2 years of age and older. The lowest possible dose should be used in this age group and Phenergan Suppositories should not be used with other medicines that cause slowed breathing.


Phenergan Suppositories is used for:

The relief of allergy symptoms, including hives and nasal congestion. It is used to prevent and control pain and nausea during and after surgery. It is also used to help produce light sleep, and for the prevention of motion sickness. Phenergan Suppositories should not be used to treat asthma.

Phenergan Suppositories is a phenothiazine. It works by blocking the action of various chemicals in the brain, preventing or reducing the symptoms these chemicals cause.

Do NOT use Phenergan Suppositories if:

  • you are allergic to any ingredient in Phenergan Suppositories
  • you have severe central nervous system depression or are in a coma
  • you are taking astemizole, cisapride, terfenadine, or tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Phenergan Suppositories:

Some medical conditions may interact with Phenergan Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nervous system problems, bone marrow depression, alcoholism, heart problems, a blood disease, glaucoma, increased eye pressure, low blood pressure, liver problems, prostate problems, Parkinson disease, seizures, or Reye syndrome, or if you have been in a coma

Some MEDICINES MAY INTERACT with Phenergan Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Charcoal or lithium because they may decrease Phenergan Suppositories's effectiveness
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), astemizole, cisapride, general anesthetics (eg, thiopental), methyldopa, terfenadine, or tramadol because side effects, such as low blood pressure and seizures, may occur
  • ACE inhibitors (eg, enalapril), haloperidol, lithium, meperidine, metrizamide, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), naltrexone, polypeptide antibiotics (eg, actinomycin), or trazodone because the risk of their side effects may be increased by Phenergan Suppositories
  • Bromocriptine, epinephrine, levodopa, or pergolide because their effectiveness may be decreased by Phenergan Suppositories

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenergan Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Phenergan Suppositories:

Use Phenergan Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Wash your hands before and after using Phenergan Suppositories. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.
  • If you are using Phenergan Suppositories for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.
  • If you miss a dose of Phenergan Suppositories and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Phenergan Suppositories.

Important safety information:

  • Phenergan Suppositories may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Phenergan Suppositories with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Phenergan Suppositories; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Phenergan Suppositories. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Phenergan Suppositories may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Phenergan Suppositories. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Use extreme caution when using Phenergan Suppositories in the ELDERLY; they may be more sensitive to its effects.
  • This medicine should not be used in CHILDREN younger than 2 years old. Serious, and sometimes fatal, side effects (difficult or slowed breathing, drowsiness leading to coma) have occurred when Phenergan Suppositories has been used in children in this age group.
  • Phenergan Suppositories should be used with extreme caution in CHILDREN 2 years of age or older. The lowest effective dose should be used in children 2 years of age and older.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Phenergan Suppositories while you are pregnant. If you are or will be breast-feeding while you use Phenergan Suppositories, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Phenergan Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; increased or decreased blood pressure; increased sensitivity to the sun; nausea; occasional blurred vision; rash; sleepiness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); uncontrolled muscle movements; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include convulsions; dry mouth; flushing; hallucinations; loss of consciousness; nightmares; seizures; shortness of breath; trouble breathing; unusual drowsiness or restlessness.

Proper storage of Phenergan Suppositories:

Store Phenergan Suppositories in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep Phenergan Suppositories out of the reach of children and away from pets.

General information:

  • If you have any questions about Phenergan Suppositories, please talk with your doctor, pharmacist, or other health care provider.
  • Phenergan Suppositories is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Phenergan Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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