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All about: Phenylephrine/Pyrilamine

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Generic Name: Phenylephrine/Pyrilamine Tablets (fen-il-EF-rin/peer-IL-a-meen)
Brand Name: Examples include K-Tan and Ryna-12

Phenylephrine/Pyrilamine is used for:

Relieving symptoms of sinus congestion, sinus pressure, runny nose, and sneezing due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Phenylephrine/Pyrilamine is an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, relieving congestion and pressure.

Do NOT use Phenylephrine/Pyrilamine if:

  • you are allergic to any ingredient in Phenylephrine/Pyrilamine
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you take sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Phenylephrine/Pyrilamine :

Some medical conditions may interact with Phenylephrine/Pyrilamine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of asthma, lung problems (eg, emphysema), adrenal gland problems (eg, adrenal gland tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, a blockage of your stomach or intestines, ulcers, a blockage of your bladder, trouble urinating, an enlarged prostate, seizures, or an overactive thyroid

Some MEDICINES MAY INTERACT with Phenylephrine/Pyrilamine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Phenylephrine/Pyrilamine may be increased
  • Digoxin or droxidopa because risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by Phenylephrine/Pyrilamine
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by Phenylephrine/Pyrilamine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenylephrine/Pyrilamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Phenylephrine/Pyrilamine :

Use Phenylephrine/Pyrilamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Phenylephrine/Pyrilamine may be taken with or without food.
  • If you miss a dose of Phenylephrine/Pyrilamine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Phenylephrine/Pyrilamine .

Important safety information:

  • Phenylephrine/Pyrilamine may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Phenylephrine/Pyrilamine . Using Phenylephrine/Pyrilamine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take diet or appetite control medicines while you are taking Phenylephrine/Pyrilamine without checking with you doctor.
  • Do NOT exceed the recommended dose or take Phenylephrine/Pyrilamine for longer than prescribed without checking with your doctor.
  • If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.
  • Phenylephrine/Pyrilamine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Phenylephrine/Pyrilamine . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • If you are scheduled for allergy skin testing, do not take Phenylephrine/Pyrilamine for several days before the test because it may decrease your response to the skin tests.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Phenylephrine/Pyrilamine .
  • Use Phenylephrine/Pyrilamine with caution in the ELDERLY because they may be more sensitive to its effects.
  • Caution is advised when using Phenylephrine/Pyrilamine in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Phenylephrine/Pyrilamine , discuss with your doctor the benefits and risks of using Phenylephrine/Pyrilamine during pregnancy. It is unknown if Phenylephrine/Pyrilamine is excreted in breast milk. Do not breast-feed while taking Phenylephrine/Pyrilamine .

Possible side effects of Phenylephrine/Pyrilamine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Phenylephrine/Pyrilamine :

Store Phenylephrine/Pyrilamine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phenylephrine/Pyrilamine out of the reach of children and away from pets.

General information:

  • If you have any questions about Phenylephrine/Pyrilamine , please talk with your doctor, pharmacist, or other health care provider.
  • Phenylephrine/Pyrilamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Phenylephrine/Pyrilamine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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