20 . October , 2018 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Aprepitant

Big Image

Some commonly used brand names are:

In the U.S.—

  • Emend

Not commercially available in Canada.

Category

  • Antiemetic

Description

Aprepitant (ap-RE-pi-tant) is used in combination with other antiemetics to prevent acute and delayed nausea and vomiting associated with cancer chemotherapy.

This medicine is available only with your doctor's prescription, in the following dosage forms:

  • Oral
  • Capsules (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking aprepitant must be weighed against the good it will do. This is a decision you and your doctor will make. For aprepitant, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to aprepitant. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Aprepitant has not been studied in pregnant women. However, aprepitant has not been shown to cause birth defects or other problems in animal studies. Before taking this medicine, make sure your doctor knows if you are pregnant or plan to become pregnant.

Breast-feeding—It is not known whether aprepitant passes into breast milk. However, aprepitant is not recommended during breast feeding because it may cause unwanted effects in nursing babies.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of aprepitant in children with use in other age groups.

Older adults—This medicine has been studied in the elderly and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, elderly people may be more sensitive to the adverse effects of aprepitant which may require caution.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. When you are taking aprepitant, it is especially important that your doctor and pharmacist know if you are taking any of the following:

  • Astemizole (e.g., Hismanal) or
  • Cisapride (e.g., Propulsid) or
  • Pimozide (e.g., Orap) or
  • Terfenadine (e.g., Seldane)—These medicines may increase the chance of serious side effects and should not be taken with aprepitant.
  • Benzodiazepines, such as
  • Alprazolam (e.g., Xanax), or
  • Midazolam (e.g., Versed), or
  • Triazolam (e.g., Halcion)—These medicines may increase the risk of side effects when taken with aprepitant.
  • Dexamethasone (e.g., Decadron) or
  • Methylprednisolone (e.g., Medrol)—The dose of these medicines may need to be decreased if you take them with aprepitant.
  • Chemotherapy agents (medicine for cancer), such as
  • Docetaxel (e.g., Taxotere) or
  • Etoposide (e.g., Vepesid) or
  • Ifosfamide (e.g., Ifex) or
  • Imatinib (e.g., Gleevec) or
  • Irinotecan (e.g., Camptosar) or
  • Paclitaxel (e.g., Taxol) or
  • Vinblastine or
  • Vincristine (e.g., Vincasar PFS) or
  • Vinorelbine (e.g., Navelbine)—Careful monitoring and caution is recommended when giving with aprepitant.
  • Oral contraceptives (birth control pills)—Aprepitant may decrease the effectiveness of these medicines; additional birth control measures may be needed to decrease the risk of pregnancy.
  • Warfarin (e.g., Coumadin)—Anticoagulant effectiveness may be decreased.

Other medical problems—The presence of other medical problems may affect the use of aprepitant. Make sure you tell your doctor if you have any other medical problems, especially:

  • Severe liver problems—Aprepitant has not been studied in patients with severe liver problems.

Proper Use of This Medicine

Read the patient information provided with your medicine before starting therapy with aprepitant and each time you refill your aprepitant prescription.

Do not start taking aprepitant if you already have nausea and vomiting. Contact your doctor about what to do.

Dosing—The dose of aprepitant will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of aprepitant. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking aprepitant.

You may take aprepitant with or without food.

  • For oral dosage form (capsules):
    • For chemotherapy induced nausea and vomiting:
      • Adults—125 milligrams (mg) one hour before chemotherapy treatment (Day 1) and 80 mg once a day in the morning on Days 2 and 3.
      • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Oral contraceptives (birth control pills) may not work properly if you take them while you are taking aprepitant. Unplanned pregnancies may occur. You should use a different or additional means of birth control while you are taking aprepitant. If you have any questions about this, check with your health care professional.

If your symptoms do not improve or if they become worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Black or tarry stools; chills; cough; fever; lower back or side pain; painful or difficult urination; pale skin; shortness of breath; sore throat; ulcers, sores, or white spots in mouth; unusual bleeding or bruising; unusual tiredness or weakness

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

Incidence unknown

Blistering, peeling, loosening of skin; diarrhea; itching; joint or muscle pain; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; red irritated eyes; redness of skin; red skin lesions, often with a purple center; skin rash; slow or irregular heartbeat

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More common

Acid or sour stomach; belching; confusion; decreased urination; dizziness; dry mouth; fainting; heartburn; hiccups; increase in heart rate; indigestion; lack or loss of strength; lightheadedness; loss of appetite; nausea; rapid breathing; stomach discomfort, upset, or pain; sunken eyes; swelling or inflammation of the mouth; thirst; weight loss; wrinkled skin

Less common

Burning feeling in chest or stomach; hot flushes; indigestion; pain or discomfort in chest, upper stomach, or throat; tenderness in stomach area

Incidence unknown

Confusion about identity, place, and time

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 09/19/2003
Revised: 11/15/2005

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Recent Drug Updates at DrugIndexOnline:





Bleph-10 Bleph-10
Generic name: Sulfacetamide sodium Brand names: Bleph-10, Sodium Sulamyd Why is Bleph-10 prescribed? Sodium Sulamyd is used in the treatment of eye inflammations, corneal ulcer, and other eye infections. It may be used along with an oral sulfa drug to treat a serious eye infection called trachom more...

carbetapentane, phenylephrine, and pyrilamine carbetapentane, phenylephrine, and pyrilamine
Generic Name: carbetapentane, phenylephrine, and pyrilamine (car bay tah PEN tane, feh nill EH frin, pie RIH la meen) Brand Names: What is carbetapentane, phenylephrine, and pyrilamine? Pyrilamine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine i more...

Chlorpromazine Hydrochloride Intensol Chlorpromazine Hydrochloride Intensol
Some commonly used brand names are: In the U.S.— Chlorpromazine Hydrochloride Intensol 1 Compazine 8 Compazine Spansule 8 Mellaril 11 Mellaril Concentrate 11 Mellaril-S 11 Permitil 2 Permitil Concentrate 2 Prolixin 2 Prolixin Concentrate 2 Prolixin Decanoate 2 Prolixin Enanthate 2 Serenti more...

Cortisporin-TC Otic Cortisporin-TC Otic
Generic name: Colistin sulfate, Neomycin sulfate, Hydrocortisone acetate, Thonzonium bromide Brand names: Cortisporin-TC Otic Why is Cortisporin-TC Otic prescribed? Cortisporin-TC is a liquid suspension used to treat external ear infections. They may also be prescribed after ear surgery such as more...

Diovol Diovol
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...

Imitrex Tablets Imitrex Tablets
Generic Name: Sumatriptan Tablets (SOO-ma-TRIP-tan) Brand Name: ImitrexImitrex is used for:The treatment of migraine headaches with or without aura (eg, flashing lights, wavy lines, dark spots). It may also be used for other conditions as determined by your doctor. Imitrex is a serotonin 5-HT 1r more...

Liquid PedvaxHIB Liquid PedvaxHIB
Generic Name: haemophilus b conjugate (PRP-OMP) vaccine (hem OFF il us B KON ju gate) Brand Names: Liquid PedvaxHIB What is haemophilus B conjugate (PRP-OMP) vaccine? Haemophilus B is a type of influenza (flu) caused by bacteria. Haemophilus B bacteria can infect the lungs or throat, a more...

Methocarbamol Methocarbamol
Some commonly used brand names are: In the U.S.— EZE-DS 3 Maolate 2 Paraflex 3 Parafon Forte DSC 3 Relaxazone 3 Remular 3 Remular-S 3 Robaxin 5 Robaxin-750 5 Skelaxin 4 Soma 1 Strifon Forte DSC 3 Vanadom 1 In Canada— Robaxin 5 Robaxin-750 5 Soma 1 Note: For quick reference, more...