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All about: Polymyxin B Sulfate/Trimethoprim Solution

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Generic Name: Polymyxin B Sulfate/Trimethoprim Eye Solution (POL-ee-MIX-in/trye-METH-oh-prim)
Brand Name: Polytrim

Polymyxin B Sulfate/Trimethoprim Solution is used for:

Treating eye infections caused by certain bacteria.

Polymyxin B Sulfate/Trimethoprim Solution is an antibiotic combination. It works by killing the bacteria.

Do NOT use Polymyxin B Sulfate/Trimethoprim Solution if:

  • you are allergic to any ingredient in Polymyxin B Sulfate/Trimethoprim Solution

Contact your doctor or health care provider right away if any of these apply to you.

Before using Polymyxin B Sulfate/Trimethoprim Solution:

Some medical conditions may interact with Polymyxin B Sulfate/Trimethoprim Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have the blood disease porphyria

Some MEDICINES MAY INTERACT with Polymyxin B Sulfate/Trimethoprim Solution. Because little, if any, of Polymyxin B Sulfate/Trimethoprim Solution is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Polymyxin B Sulfate/Trimethoprim Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Polymyxin B Sulfate/Trimethoprim Solution:

Use Polymyxin B Sulfate/Trimethoprim Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • To use Polymyxin B Sulfate/Trimethoprim Solution in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
  • To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
  • Do not wear contact lenses while you are using Polymyxin B Sulfate/Trimethoprim Solution. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.
  • If you miss a dose of Polymyxin B Sulfate/Trimethoprim Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Polymyxin B Sulfate/Trimethoprim Solution.

Important safety information:

  • Be sure to use Polymyxin B Sulfate/Trimethoprim Solution for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of Polymyxin B Sulfate/Trimethoprim Solution may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • If redness, irritation, swelling, or pain continues or worsens, check with your doctor.
  • Polymyxin B Sulfate/Trimethoprim Solution should be used with extreme caution in CHILDREN younger than 2 months old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Polymyxin B Sulfate/Trimethoprim Solution while you are pregnant. It is not known if Polymyxin B Sulfate/Trimethoprim Solution is found in breast milk. If you are or will be breast-feeding while you use Polymyxin B Sulfate/Trimethoprim Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Polymyxin B Sulfate/Trimethoprim Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eyelid swelling; increased or persistent redness, irritation, swelling, pain, or tearing of the eye.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Polymyxin B Sulfate/Trimethoprim Solution:

Store Polymyxin B Sulfate/Trimethoprim Solution between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Polymyxin B Sulfate/Trimethoprim Solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Polymyxin B Sulfate/Trimethoprim Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Polymyxin B Sulfate/Trimethoprim Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Polymyxin B Sulfate/Trimethoprim Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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