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All about: Prelone

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Generic Name: prednisolone (pred NIZ o lone)
Brand Names: Orapred, Orapred ODT, Pediapred, Prelone

What is Prelone (prednisolone)?

Prednisolone is in a group of drugs called steroids. Prednisolone reduces swelling and lowers the body's immune response.

Prednisolone is used to treat many immune and allergic disorders, such as arthritis, lupus, psoriasis, asthma, multiple sclerosis, and ulcerative colitis. It is also used to treat many different conditions such as endocrine (hormonal) disorders when the body does not produce enough of its own steroids.

Prednisolone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Prelone (prednisolone)?

Do not take prednisolone if you have a serious fungal infection, or if you have recently received a "live" vaccine. Prednisolone weakens the body's immune system and you could become ill. Carry an ID card or wear a medical alert bracelet stating that you are taking prednisolone, in case of emergency.

There are many other medicines that can interact with prednisolone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Do not stop using prednisolone without first talking to your doctor. You may need to use less and less before you stop the medication completely. Steroid medicine can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using prednisolone. Seek emergency medical attention if you think you have used too much of this medicine. A single large dose of prednisolone is not expected to produce life-threatening symptoms. Overdose is more likely to be caused by taking large doses over a long period of time. Symptoms of a prednisolone overdose may include weight gain (especially around the stomach), a round face, excessive appetite, hair loss or increased hair growth, acne, bruising, swelling in your hands or feet, fast heart rate, worsened menopause symptoms, numbness or tingling, feeling light-headed or fainting.

Who should not take Prelone (prednisolone)?

Do not take prednisolone if you have a serious fungal infection, or if you have recently received a "live" vaccine. Prednisolone weakens the body's immune system and you could become ill.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

  • heart disease, congestive heart failure;

  • kidney disease;
  • liver disease or cirrhosis;
  • high blood pressure;

  • thyroid problems;

  • unusual diarrhea;

  • a nerve or muscle disorder such as myasthenia gravis;

  • a history of mental illness;

  • osteoporosis;

  • glaucoma or cataracts;

  • herpes infection of the eye; or

  • if you have recently been in a tropical area.

If you have any of these conditions, you may not be able to use prednisolone, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Prednisolone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Steroid medicine can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using prednisolone. Older adults, especially postmenopausal women, may be more likely to develop osteoporosis while taking steroids. If you are at least 65 years old, your doctor may want to check your bone mineral density while you are taking prednisolone.

How should I take Prelone (prednisolone)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take each dose with a full glass of water. Take prednisolone with food or milk to lessen stomach upset.

Measure the liquid form of prednisolone with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

To take prednisolone orally disintegrating tablets (Orapred ODT):

  • Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

  • Do not use an orally disintegrating tablet that has been broken.
  • Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.

  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

  • Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

This medication can cause you to have false negative skin tests. Tell any doctor who treats you that you are using prednisolone.

Do not stop using prednisolone without first talking to your doctor. You may need to use less and less before you stop the medication completely. Carry an ID card or wear a medical alert bracelet stating that you are taking prednisolone, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking prednisolone. Store prednisolone at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. A single large dose of prednisolone is not expected to produce life-threatening symptoms. Overdose is more likely to be caused by taking large doses over a long period of time.

Symptoms of a prednisolone overdose may include weight gain (especially around the stomach), a round face, excessive appetite, hair loss or increased hair growth, acne, bruising, swelling in your hands or feet, fast heart rate, worsened menopause symptoms, numbness or tingling, feeling light-headed or fainting.

What should I avoid while taking Prelone (prednisolone)?

Avoid drinking alcohol, which can cause harmful effects on your stomach while you are using prednisolone.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection. Tell your doctor if you have been around someone who has chicken pox or measles.

Do not receive a "live" vaccine while you are being treated with prednisolone. You may become ill. Other types of vaccines may not work as well during your treatment with prednisolone.

Prelone (prednisolone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • feeling short of breath, even with mild exertion;

  • swelling or sudden weight gain (more than 5 pounds in a day or two);

  • swelling of your ankles or feet;

  • severe pain behind your eyes;

  • severe depression;

  • unusual thoughts or behaviors;

  • diarrhea; or

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Other, less serious side effects may be more likely to occur, such as:

  • sleep problems (insomnia);

  • depressed mood;

  • increased sweating, thinning of the skin;

  • slow wound healing;

  • irregular menstrual periods;

  • acne;

  • increased hair growth;

  • weight gain, increased appetite;

  • muscle weakness, lack of coordination; or

  • nausea, bloating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Prelone (prednisolone)?

Before taking prednisolone, tell your doctor if you are using any of the following drugs:

  • phenytoin (Dilantin);

  • ephedrine (found in many diet pills);

  • a diuretic (water pill);

  • digitalis or digoxin (Lanoxin);

  • amphotericin B (Fungizone, Ambisome, Abcelet);

  • rifampin (Rifater, Rifamate, Rimactane);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • insulin or diabetes medicine taken by mouth;

  • estrogens (birth control pills, hormone replacement therapy);

  • ketoconazole (Nizoral);

  • a blood thinner such as warfarin (Coumadin);

  • a medicine to treat nerve or muscle disorders, including tacrine (Cognex), donepezil (Aricept), rivastigmine (Exelon), and pyridostigmine (Mestinon), and neostigmine (Prostigmin);

  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or

  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.

If you are using any of these drugs, you may not be able to use prednisolone or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect prednisolone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has additional information about prednisolone written for health professionals that you may read.

What does my medication look like?

Prednisolone is available with a prescription under several brand and generic names. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Prelone Syrup 15 mg per 5 mL--red, cherry-flavored liquid

  • Pediapred Solution 6.7 mg per 5 mL--colorless to light-straw-colored solution

  • Orapred ODT--white, orally disintegrating tablet

  • Orapred Solution 15 mg per 5 mL-pale to light yellow grape-flavored liquid

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.05. Revision Date: 8/2/06 4:49:39 PM.

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