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All about: Prinivil

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Generic Name: Lisinopril Tablets (lye-SIN-oh-pril)
Brand Name: Examples include Prinivil and Zestril

Prinivil can cause injury and even death to the fetus when used after the third month of pregnancy. Contact your doctor at once if you think you may be pregnant.


Prinivil is used for:

Treating high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. It may also be used for other conditions as determined by your doctor.

Prinivil is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This lowers blood pressure and helps the heart to pump blood more easily.

Do NOT use Prinivil if:

  • you are allergic to any ingredient in this medicine
  • you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor
  • you are in your second or third trimester of pregnancy
  • the patient is a CHILD with severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prinivil :

Some medical conditions may interact with Prinivil . Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are a woman of childbearing age
  • if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney problems, or diabetes
  • if you have a history of stroke, recent heart attack, or kidney transplant
  • if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)
  • if you are dehydrated or have low blood volume
  • if you have high blood potassium levels, low blood sodium levels, or are on a low salt (sodium) diet
  • if you are on dialysis or are scheduled to have major surgery

Some MEDICINES MAY INTERACT with Prinivil . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased
  • Aldosterone blockers (eg, eplerenone), potassium-sparing diuretics (eg, spironolactone, triamterene), or potassium supplements because the risk of high blood potassium levels may be increased
  • Insulin, sulfonylureas (eg, glipizide), or other oral diabetes medicines (eg, metformin) because the risk of low blood sugar may be increased
  • Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) because they may decrease Prinivil 's effectiveness
  • Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Prinivil

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prinivil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prinivil :

Use Prinivil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Prinivil may be taken with or without food.
  • If you miss a dose of Prinivil , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prinivil .

Important safety information:

  • Prinivil may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Prinivil with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Prinivil may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Prinivil may not work as well in black patients. They may also be at greater risk of developing angioedema. Contact your doctor if your symptoms do not improve or if they become worse.
  • Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.
  • Rarely, Prinivil may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Tell your doctor or dentist that you take Prinivil before you receive any medical or dental care, emergency care, or surgery.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients- Prinivil may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood pressure, blood electrolyte levels, heart function, or kidney or liver function, may be performed while you use Prinivil . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Prinivil with caution in the ELDERLY; they may be more sensitive to its effects.
  • Prinivil should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY AND BREAST-FEEDING: Prinivil may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Prinivil is found in breast milk. Do not breast-feed while taking Prinivil .

Possible side effects of Prinivil :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; dizziness; headache; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; hoarseness); chest pain; dark urine; decreased urination; difficulty swallowing; infection (eg, fever, chills, persistent sore throat); irregular or slow heartbeat; stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include fainting; severe dizziness or lightheadedness; weakness.

Proper storage of Prinivil :

Store Prinivil at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prinivil out of the reach of children and away from pets.

General information:

  • If you have any questions about Prinivil , please talk with your doctor, pharmacist, or other health care provider.
  • Prinivil is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Prinivil . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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