21 . April , 2019 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Propylthiouracil (PTU)

Big Image ( PTU ) Pronouncation: (pro-puhl-thigh-oh-YOU-rah-sill)
Class: Antithyroid agent

Trade Names:
- Tablets 50 mg

Propyl-Thyracil (Canada)

Mechanism of Action


Inhibits synthesis of thyroid hormones.



Readily absorbed from the GI tract. Bioavailability is 80% to 95%. T max is 1.99 hr; C max is 7.12 mcg/mL.


Protein binding is 75% to 80%, primarily to albumin. Vd is approximately 0.4 L/kg.


Actively concentrated by the thyroid. Metabolized rapidly in the liver; undergoes glucuronidation.


Urine (35%); less than 1% as unchanged. T 1/2 is 1 to 2 hr. Total body clearance is approximately 7 L/hr.


Approximately 17 wk to normalize serum T 3 and T 4 concentrations.

Indications and Usage

Long-term therapy of hyperthyroidism; amelioration of hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy; when thyroidectomy is contraindicated or not advisable.

Unlabeled Uses

Management of alcoholic liver disease.


Hypersensitivity to antithyroid drugs; lactating women.

Dosage and Administration


PO The initial dose is 300 mg/day in 3 equal doses q 8 hr. In patients with severe hyperthyroidism or very large goiters, initial dose is usually 400 mg/day, occasionally up to 600 to 900 mg/day. The maintenance dose is 100 to 150 mg/day in divided doses q 8 hr.

Children over 10 yr

PO The initial dose is 150 to 300 mg/day in divided doses q 8 hr. The maintenance dose is determined by response.

Children 6 to 10 yr

PO The initial dose is 50 to 150 mg/day in divided doses q 8 hr.

Alternate Dosing for Children

PO The initial dose is 5 to 7 mg/kg/day in divided doses q 8 hr. The maintenance dose is 1/ 3 to 2/ 3 initial dose, beginning when patient is euthyroid.

General Advice

Give with meals to minimize GI irritation.


Store in tight, light-resistant container at room temperature.

Drug Interactions


Altered anticoagulant action.

Beta blockers

Increased effects of beta blockers.

Digitalis glycosides

Increased digitalis levels, resulting in toxicity.


Altered theophylline clearance in hyperthyroid or hypothyroid patients.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Paresthesias; neuritis; headache; vertigo; drowsiness; neuropathies; CNS stimulation; depression.


Rash; urticaria; pruritus; erythema nodosum; skin pigmentation; exfoliative dermatitis; lupus-like syndrome (splenomegaly, hepatitis, periarteritis; hypoprothrombinemia; bleeding).


Loss of taste; sialadenopathy.


Nausea; vomiting; epigastric distress.




Jaundice; hepatitis.


Inhibition of myelopoiesis (eg, agranulocytosis, leukopenia, granulocytopenia, thrombocytopenia); aplastic anemia; hypoprothrombinemia; periarteritis.


Abnormal hair loss; arthralgia; myalgia; edema; lymphadenopathy; drug fever; interstitial pneumonitis; insulin autoimmune syndrome (hypoglycemia).



Category D .


Avoid nursing. However, if antithyroid drug is essential, PTU is preferred antithyroid agent while nursing.


Hepatotoxicity has occurred in pediatric patients. Discontinue drug immediately if signs and symptoms of hepatic dysfunction develop.


Potentially most serious side effect. Discontinue drug if agranulocytosis, aplastic anemia, hepatitis, fever, or exfoliative dermatitis occur.

Hemorrhagic effects

May cause hypoprothrombinemia and bleeding.



Nausea, vomiting, epigastric distress, headache, fever, arthralgia, pruritus, edema, pancytopenia; most serious effect: agranulocytosis.

Patient Information

  • Instruct patient to take resting pulse daily and encourage patient to keep recorded chart.
  • Advise patient to monitor weight at least 2 to 3 times/wk or per health care provider instruction, obtaining weight at same time, using same scale. Encourage patient to keep recorded chart.
  • Emphasize importance of following dietary restrictions regarding shellfish, iodized salt and other foods high in iodine.
  • Explain that desired response may take several months if the thyroid is greatly enlarged.
  • Advise patient to carry Medi-Alert identification at all times describing medications.
  • Instruct patient to notify dentist or health care provider of drug regimen before surgical or dental procedures.
  • Emphasize importance of follow-up visits to monitor effectiveness of drug therapy.
  • Caution patient not to stop taking medication abruptly to avoid thyroid crisis.
  • Instruct patient to report the following symptoms to health care provider: Sore throat, fever, rash, mouth sores; cold intolerance, mental depression; tachycardia, irritability; persistent nausea, steatorrhea or vomiting, drowsiness, yellowing of skin or whites of eyes; unusual bleeding or bruising.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other activities requiring mental alertness.
  • Instruct patient not to take otc medications without consulting health care provider.

Recent Drug Updates at DrugIndexOnline:

Acetoxyl 10 Gel Topical Acetoxyl 10 Gel Topical
Some commonly used brand names are: In the U.S.— Acne-Aid Vanishing Cream Acne-Aid Aqua Gel Ambi 10 Acne Medication Benoxyl 5 Lotion Benoxyl 10 Lotion Benzac AC 21/2 Gel Benzac AC 5 Gel Benzac AC 10 Gel Benzac AC Wash 21/2 Benzac AC Wash 5 Benzac AC Wash 10 Benzac 5 Gel Benzac 10 Gel Benz more...

Actifed Sinus Day and Night Actifed Sinus Day and Night
Generic Name: acetaminophen, diphenhydramine, and pseudoephedrine (a seet a MIN oh fen, dye fen HYE dra meen, soo doe e FED rin) Brand Names: Actifed Sinus Day and Night, Benadryl Cold, Contac Day and Night Allergy, Tylenol Allergy Sinus NightTime, Tylenol Nightime Flu Gelcap Maximum Str more...

Anagrelide Anagrelide
Generic Name: Anagrelide hydrochloride Dosage Form: Capsules Rx only Anagrelide Description Anagrelide hydrochloride is a platelet-reducing agent. Anagrelide hydrochloride is 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride monohydrate and its structural formula is: more...

Cotazym E.C.S. 8 Cotazym E.C.S. 8
Some commonly used brand names are: In the U.S.— Cotazym Cotazym-S Creon 5 Creon 10 Creon 20 Enzymase-16 Ilozyme Ku-Zyme HP Lipram 4500 Lipram-CR10 Lipram-PN10 Lipram-UL12 Lipram-PN16 Lipram-UL18 Lipram-CR20 Lipram-UL20 Lipram-PN20 Pancoate Pancrease Pancrease MT 4 Pancrease MT 10 Pancrea more...

estradiol and norgestimate estradiol and norgestimate
Generic Name: estradiol and norgestimate (ess tra DYE all and nor JESS tih mate) Brand Names: Ortho-Prefest What is estradiol and norgestimate? Estradiol is a female sex hormone that is involved in the development and maintenance of the female reproductive system. Norgestimate is a form more...

Neo-Synephrine 12 Hour Spray Nasal Neo-Synephrine 12 Hour Spray Nasal
Some commonly used brand names are: In the U.S.— Afrin Cherry 12 Hour Nasal Spray Afrin Extra Moisturizing 12 Hour Nasal Spray Afrin Original 12 Hour Nasal Spray Afrin Original 12 Hour Nose Drops Afrin Sinus 12 Hour Nasal Spray Afrin Original 12 Hour Pump Mist Dristan 12-Hr Nasal Spray Du more...

Neomycin Sulfate Tablets Neomycin Sulfate Tablets
Dosage Form: Tablets BOXED WARNING WARNINGS: SYSTEMIC ABSORPTION OF NEOMYCIN OCCURS FOLLOWING ORAL ADMINISTRATION AND TOXIC REACTIONS MAY OCCUR. Patients treated with neomycin should be under close clinical observation because of the potential toxicity associated with their use. NEUROTOXICITY (I more...

Phillips' Phillips'
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...