25 . February , 2018 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Auranofin

Big Image Pronouncation: (or-RAIN-oh-fin)
Class: Gold compound

Trade Names:
Ridaura
- Capsules 3 mg

Mechanism of Action

Pharmacology

Gold compounds relieve symptoms of arthritis but do not cure this disease; decrease rheumatoid factor concentrations and immunoglobulins.

Pharmacokinetics

Absorption

Because of rapid metabolism, intact auranofin has never been detected in the blood. Approximately 25% of the gold in auranofin is absorbed. Steady-state gold concentrations of approximately 0.68 mcg/mL are achieved in approximately 3 mo.

Distribution

Approximately 40% of auranofin gold is associated with red cells, and 60% is associated with serum proteins.

Metabolism

Rapidly metabolized.

Elimination

Mean terminal plasma t ½ of auranofin gold at steady-state is 26 days. Approximately 60% of absorbed gold of single auranofin dose is excreted in urine; remainder is excreted in the feces.

Indications and Usage

Relief of symptoms of active adult rheumatoid arthritis poorly controlled with other therapies.

Unlabeled Uses

Treatment of pemphigus and psoriatic arthritis.

Contraindications

Standard considerations.

Dosage and Administration

Adults

PO 6 mg/day or 3 mg twice daily. If no response by 6 mo, dose may be increased to 3 mg 3 times daily. Parenteral route may be used when control cannot be achieved by oral form.

Children

Auranofin is not recommended for children; safety and efficacy have not been established. If prescribed, however, the following doses have been recommended. 0.1 mg/kg/day (initial dose); 0.15 mg/kg/day (maintenance dose); 0.2 mg/kg/day (max dose).

Storage/Stability

Protect product from light and moisture.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Reactions can occur months after therapy is discontinued.

CNS

Confusion; hallucinations; seizures.

Dermatologic

Dermatitis; pruritus; grey-blue pigmentation on sun-exposed skin; exfoliative dermatitis; angioedema.

EENT

Mucositis that may be preceded by metallic taste; conjunctivitis; corneal gold deposition; metallic taste; inflammation of the upper respiratory tract; pharyngitis.

GI

Diarrhea; abdominal pain; anorexia; dyspepsia; flatulence; GI bleeding; enterocolitis; gastritis; colitis; tracheitis.

Genitourinary

Nephrotic syndrome and glomerulitis with proteinuria and hematuria.

Hematologic

Anemia; thrombocytopenia; leukopenia; aplastic anemia.

Hepatic

Elevated liver enzymes; jaundice; hepatitis.

Respiratory

Interstitial pneumonitis; pulmonary fibrosis.

Miscellaneous

Vaginitis; glossitis.

Precautions

Monitor

Lab values

Review laboratory values for indications of gold toxicity such as decreased hemoglobin, less than 4,000 WBC/mm 3 , platelets less than 100,000 to 150,000/cu mm, proteinuria, and elevated liver enzymes.

Toxicity

Observe patient for early symptoms of toxicity such as a metallic taste in the mouth, pruritus or rash.


Pregnancy

Category C .

Lactation

Excreted in breast milk.

Children

Safety and efficacy not established.

Elderly

Tolerance decreases with age.

Special Risk Patients

Use with caution in patients with diabetes mellitus, CHF, history of blood dyscrasias, allergy or hypersensitivity to other gold products, skin rash, previous kidney or liver disease, marked hypertension, compromised circulation or inflammatory bowel disease.

Overdosage

Symptoms

Renal damage (eg, hematuria, proteinuria), hematologic reactions (eg, thrombocytopenia), nausea, vomiting, diarrhea, fever, skin disorders.

Patient Information

  • Instruct patient to immediately report any adverse effects of therapy including dermatitis and pruritus, weakness, fatigue, hematuria, sore mouth, indigestion, diarrhea, metallic taste in mouth, or unusual bruising.
  • Caution patient to minimize exposure to the sun and other sources of ultraviolet light. Explain the need to wear sunscreen and protective clothing outdoors.
  • Advise patient to keep appointments with health care providers for continued assessment and monitoring of renal, hepatic and hematologic functions.
  • Review oral hygiene, including use of soft toothbrush, daily flossing and avoidance of strong, commercial mouthwashes. If mild stomatitis develops, an isotonic NaCl and sodium bicarbonate solution can be used.
  • Alert women to the potential risks of using gold therapy during pregnancy.

Recent Drug Updates at DrugIndexOnline:





Activella Activella
Some commonly used brand names are: In the U.S.— Activella 3 femhrt 2 Ortho-Prefest 1 Other commonly used names are: Ethinylestradiol [Ethinyl estradiol] Ethinyloestradiol [Ethinyl estradiol] Norethindrone [Norethisterone] Note: For quick reference, the following estrogens an more...

Amprenavir Solution Amprenavir Solution
Generic Name: Amprenavir Oral Solution (am-PREN-ah-veer) Brand Name: AgeneraseThis form of amprenavir contains propylene glycol. Therefore, it must not be used in infants and children younger than 4 years of age, pregnant women, patients with severe kidney or liver problems, or in patients who t more...

Cytoxan Tablets Cytoxan Tablets
Generic Name: Cyclophosphamide Tablets (sigh-kloe-FOSS-fuh-mide) Brand Name: CytoxanCytoxan is used for:Treating certain types of the following cancers: lymphoma, multiple myeloma, leukemia, mycosis fungoides, neuroblastoma, ovarian cancer, eye cancer, and breast cancer. It is usually used in co more...

Digoxin tablets Digoxin tablets
Dosage Form: Tablets Digoxin Description Digoxin is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term & more...

Dilantin Kapseals Dilantin Kapseals
Some commonly used brand names are: In the U.S.— Cerebyx 2 Dilantin 4 Dilantin-125 4 Dilantin Infatabs 4 Dilantin Kapseals 4 Mesantoin 3 Peganone 1 Phenytek 4 In Canada— Cerebyx 2 Dilantin 4 Dilantin-30 4 Dilantin-125 4 Dilantin Infatabs 4 Another commonly used name for phenytoin more...

Hyosophen Hyosophen
Generic Name: belladonna alkaloids and phenobarbital (bell uh DAHN uh AL kuh loydz and feen oh BAR bih tall) Brand Names: Antispas, Antispasmodic, Barbidonna, Donnapine, Donnatal, Donnatal Extentabs, Elixiral, Hyosophen, Spasmolin What is Hyosophen (belladonna alkaloids and phenobarbital more...

Iodoquinol Iodoquinol
Generic Name: Iodoquinol Tablets (eye-oh-doe-KWIN-ole) Brand Name: YodoxinIodoquinol is used for:Treating certain infections of the intestine. It may also be used for certain conditions as determined by your doctor. Iodoquinol is an amebicide. It works by killing parasites (amoeba) in the inte more...

Niacinamide Niacinamide
Generic Name: Niacinamide Tablets (NYE-a-sin-a-mide) Brand Name: Generic only. No brands available.Niacinamide is used for:Treating or preventing low levels of niacin (vitamin B3). It may also be used for other conditions as determined by your doctor. Niacinamide is a vitamin B supplement. It w more...