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All about: Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine

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Generic Name: Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine Tablets (a-SEET-a-MIN-oh-fen/DEX-troe-meth-OR-fan/gwye-FEN-e-sin /FEN-il-EF-rin)
Brand Name: Examples include Tylenol Cold Head Congestion and Tylenol Cold Multi Symptom

Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine is used for:

Relieving pain, congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine is an analgesic, decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, loosening mucus and lung secretions in the chest, and making coughs more productive. The analgesic and cough suppressant works in the brain to decrease pain and to help decrease the cough reflex to reduce a dry cough.

Do NOT use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine if:

  • you are allergic to any ingredient in Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine
  • you have severe high blood pressure, rapid heartbeat, severe heart blood vessel disease, or other severe heart problems
  • you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine :

Some medical conditions may interact with Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of glaucoma, an enlarged prostate or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, an overactive thyroid, seizures, stroke, liver problems, or severe kidney problems, or if you drink 3 or more drinks with alcohol per day
  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
  • if you smoke or have a history of addiction to alcohol

Some MEDICINES MAY INTERACT with Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine 's side effects may be increased
  • Anticoagulants (eg, warfarin), digoxin, or droxidopa because the risk of side effects such as bleeding, irregular heartbeat, or heart attack may be increased
  • Bromocriptine because the risk of its side effects may be increased by Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine :

Use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may be taken with or without food.
  • Drink plenty of water while taking Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine .
  • If you miss a dose of Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine .

Important safety information:

  • Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not take appetite suppressants while you use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine unless your doctor tells you to.
  • Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine contains acetaminophen, dextromethorphan, guaifenesin, and phenylephrine. Before you start any new medicine, check the label to see if it has any of these medicines in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 7 days or if they get worse, check with your doctor.
  • Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may harm your liver. Your risk may be greater if you drink alcohol while you are using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine . Talk to your doctor before you take Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine or other fever reducers if you drink more than 3 drinks with alcohol per day.
  • Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine .
  • Tell your doctor or dentist that you take Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine before you receive any medical or dental care, emergency care, or surgery.
  • Use Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine in CHILDREN; they may be more sensitive to its effects.
  • Different brands of Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
  • PREGNANCY and BREAST-FEEDING: It is not known if Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine while you are pregnant. It is not known if Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine is found in breast milk. Do not breast-feed while taking Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine .

Possible side effects of Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; stomach pain; unusually fast, slow, or irregular heartbeat; vomiting; yellowing of skin or eyes.

Proper storage of Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine :

Store Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine out of the reach of children and away from pets.

General information:

  • If you have any questions about Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine , please talk with your doctor, pharmacist, or other health care provider.
  • Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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