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All about: Azatadine maleate, Pseudoephedrine sulfate

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Generic name: Azatadine maleate, Pseudoephedrine sulfate
Brand names: Rynatan, Trinalin

Why is Azatadine maleate, Pseudoephedrine sulfate prescribed?

Trinalin and Rynatan are long-acting antihistamine/decongestants that relieve nasal stuffiness and middle ear congestion caused by hay fever and ongoing nasal inflammation. They can be used alone or with antibiotics and analgesics such as aspirin or acetaminophen. Azatadine, the antihistamine in these products, reduces itching and swelling and dries up secretions from the nose, eyes, and throat. Pseudoephedrine, the decongestant, reduces nasal congestion and makes breathing easier.

Most important fact about Azatadine maleate, Pseudoephedrine sulfate

This medication may cause drowsiness. You should not drive or operate dangerous machinery or participate in any hazardous activity that requires full mental alertness until you know how you react to Azatadine maleate, Pseudoephedrine sulfate.

How should you take Azatadine maleate, Pseudoephedrine sulfate?

Take Azatadine maleate, Pseudoephedrine sulfate as indicated; do not take more than your doctor has prescribed.

--If you miss a dose...

If you take Trinalin on a regular schedule, take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Azatadine maleate, Pseudoephedrine sulfate.

  • More common side effects may include:
    Abdominal cramps, acute inflammation of the inner ear, anemia, anxiety, blood disorders, blurred vision, chest pain, chills, confusion, constipation, convulsions, diarrhea, difficulty breathing, dilated pupils, disturbed coordination, dizziness, dry mouth, nose, and throat, early menstruation, exaggerated feeling of well-being, excessive perspiration, excitement, extreme calm (sedation), fatigue, fear, fluttery heartbeat, frequent urination, hallucinations, headache, high blood pressure, hives, hysteria, increased chest congestion, increased sensitivity to light, insomnia, irregular heartbeat, irritability, loss of appetite, low blood pressure, nausea, nervousness, painful or difficult urination, pale skin, rapid heartbeat, rash, restlessness, ringing in the ears, severe allergic reaction, sleepiness, stuffy nose, tension, tightness in chest, tingling or pins and needles, tremor, upset stomach, urinary retention, vertigo, vomiting, weakness, wheezing

Why should Azatadine maleate, Pseudoephedrine sulfate not be prescribed?

These products should be avoided if you have narrow-angle glaucoma or difficulty urinating, if you are taking one of the antidepressant drugs known as MAO inhibitors or have taken one within the past two weeks, if you have severe high blood pressure, severe heart disease, or an overactive thyroid, or if you are sensitive to or have ever had an allergic reaction to any of its ingredients.

This drug should not be used to treat asthma and other lower respiratory tract diseases.

Special warnings about Azatadine maleate, Pseudoephedrine sulfate

These products should be used with care if you have a peptic ulcer or other upper intestinal obstruction, bladder obstruction due to an enlarged prostate or other bladder problems, a history of bronchial asthma, heart disease, high blood pressure, increased eye pressure, or diabetes.

Pseudoephedrine can be habit-forming at high doses. Remember that Azatadine maleate, Pseudoephedrine sulfate can make you feel drowsy. Be careful driving, operating machinery, or using appliances.

The products may cause dizziness, extreme calm (sedation), and low blood pressure in people aged 60 and over. It is also more likely to cause such side effects as confusion, convulsions, hallucinations, and death in this age group.

Possible food and drug interactions when taking Azatadine maleate, Pseudoephedrine sulfate

Alcohol may increase the effects of Azatadine maleate, Pseudoephedrine sulfate. Do not drink alcohol while taking Azatadine maleate, Pseudoephedrine sulfate.

If Azatadine maleate, Pseudoephedrine sulfate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Trinalin with the following:

Alcohol
Antacids such as Maalox
Barbiturates such as phenobarbital
Beta-blocking blood pressure drugs such as Tenormin and Inderal
Blood thinners such as Coumadin
Digitalis (Lanoxin)
Drugs for depression such as Prozac and Elavil
High blood pressure drugs such as Aldomet, Diupres, Hydropres, and Inversine
Kaolin (Kaopectate)
MAO inhibitor drugs such as the antidepressants Nardil and Parnate
Sedatives such as Nembutal and Seconal
Tranquilizers such as Xanax and Valium

Special information if you are pregnant or breastfeeding

Although the effects of these products during pregnancy have not been adequately studied, antihistamines have caused severe reactions in premature and newborn babies when used in the last 3 months of pregnancy. If you are pregnant or plan to become pregnant, notify your doctor immediately. The drugs may appear in breast milk and could affect a nursing infant. If Azatadine maleate, Pseudoephedrine sulfate is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage

ADULTS AND CHILDREN 12 AND OVER:

The usual dosage is 1 tablet twice a day.

Children under age 12 should not take these products.

Overdosage

Any medication taken in excess can have serious consequences. An overdose of these products can be fatal. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of overdose may include:
    Anxiety, bluish color caused by lack of oxygen, blurred vision, chest pain, coma, convulsions, decreased mental alertness, delusions, difficulty sleeping, difficulty urinating, dizziness, excitement, extreme calm (sedation), exaggerated sense of well-being, fluttery heartbeat, giddiness, hallucinations, headache, high blood pressure/low blood pressure, irregular heartbeat, lack of muscle coordination, muscle tenseness, muscle weakness, nausea, perspiration, rapid heartbeat, restlessness, ringing in the ears, temporary interruption of breathing, thirst, tremors, vomiting
  • Overdose symptoms more common in children may include:
    Dry mouth, fixed, dilated pupils, flushing, overstimulation, stomach and intestinal problems, very high body temperature

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