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All about: Y-90 Zevalin

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Generic Name: Ibritumomab Tiuxetan with Yttrium-90 (EYE-bri-TOOM-oh-mab tye-UX-e-tan)
Brand Name: Y-90 Zevalin

Rituximab, a medicine used along with Y-90 Zevalin , may cause serious, sometimes fatal side effects, such as difficulty breathing, lung problems, heart attack, irregular heartbeats, or shock. If these side effects are going to occur, they usually occur with the first infusion within 30 minutes to 2 hours. Seek immediate medical attention if you develop severe trouble breathing, swelling, dizziness, lightheadedness, irregular heartbeat, or chest pain.

Y-90 Zevalin causes severe and prolonged blood problems in most patients. Patients who have certain bone marrow problems should not use Y-90 Zevalin . If you develop unusual bruising or bleeding, fever, chills, sore throat, or other signs of infection, contact your doctor immediately.

Severe and sometimes fatal skin problems have been reported with use of Y-90 Zevalin . If you experience red, swollen, blistered, or peeling skin, contact your doctor immediately.


Y-90 Zevalin is used for:

Treating non-Hodgkin lymphoma that has redeveloped or has not responded to other medicines. It is used in combination with rituximab and 2 radioactive materials (In-111 and Y-90).

Ibritumomab is a monoclonal antibody protein. It works by binding to the cells that are involved in non-Hodgkin lymphoma. It is used in combination with 2 different radioactive materials. The first radioactive material (In-111) is attached to confirm that the cells are being reached. The second radioactive material (Y-90) is attached and damages the cells Y-90 Zevalin binds to, which helps to reduce the number of abnormal cells involved in non-Hodgkin lymphoma.

Do NOT use Y-90 Zevalin if:

  • you are allergic to any ingredient in Y-90 Zevalin , murine (mice, rats) proteins, or indium
  • you have bone marrow depression

Contact your doctor or health care provider right away if any of these apply to you.

Before using Y-90 Zevalin :

Some medical conditions may interact with Y-90 Zevalin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are of childbearing age, pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have blood disorders, such as low red blood cell counts, low white blood cell counts, or low platelet counts, or failed stem cell collection

Some MEDICINES MAY INTERACT with Y-90 Zevalin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aspirin, clopidogrel, warfarin, and other medicines that thin the blood because they may increase the risk of bleeding when used with Y-90 Zevalin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Y-90 Zevalin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Y-90 Zevalin :

Use Y-90 Zevalin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Y-90 Zevalin is administered as an injection at your doctor's office, hospital, or clinic.
  • Ibritumomab is not a radioactive chemical by itself. There is no risk of radioactive exposure with this medication kit until it is combined with In-111 or Y-90; all radioactive handling precautions should be followed at that time. The radioactive medicine will be added to Y-90 Zevalin by a properly trained medical professional.
  • After being given another medicine (rituximab), ibritumomab in combination with In-111 will be injected into a vein as prescribed by the doctor. Generally, 7 to 9 days later, another rituximab dose is given, followed by Y-90 Zevalin . The dosage is based on your medical condition, response to therapy, and an established dosing guideline. Consult your doctor for details.
  • Do not use Y-90 Zevalin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Y-90 Zevalin or your dose is interrupted, contact your doctor immediately to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Y-90 Zevalin .

Important safety information:

  • Y-90 Zevalin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Y-90 Zevalin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Y-90 Zevalin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Y-90 Zevalin may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Your doctor may prescribe medicines to be taken 30 minutes before Y-90 Zevalin is given. These medicines may decrease the risk and/or severity of allergic reactions and some side effects. If you experience difficulty breathing; tightness of the chest; or swelling of the eyelids, face, or lips; or if you develop a rash or hives, tell your doctor immediately. Do not take any more doses of Y-90 Zevalin until your doctor tells you to do so.
  • Check with your doctor before having vaccinations while you are using Y-90 Zevalin .
  • Carry an ID card at all times that says you take this medication.
  • Lab tests, including complete blood cell and platelet counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Y-90 Zevalin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • Men receiving this medicine should use reliable methods of birth control while, and for at least 1 year after, taking Y-90 Zevalin . Consult your doctor for more details.
  • Women of childbearing age receiving Y-90 Zevalin should use reliable methods of birth control while, and for at least 1 year after, taking Y-90 Zevalin . Consult your doctor for more details.
  • PREGNANCY and BREAST-FEEDING: Y-90 Zevalin has been shown to cause harm to the fetus. If you think that you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Y-90 Zevalin while you are pregnant. It is not known if Y-90 Zevalin is found in breast milk. Do not breast-feed while taking Y-90 Zevalin .

Possible side effects of Y-90 Zevalin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; dizziness; flushing; headache; indigestion; joint or muscle pain; loss of appetite; nausea; runny nose; stomach pain or upset; sweating; throat irritation; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; black, bloody, or dark stools; cough; fainting; fast or irregular heartbeat; hoarseness; lightheadedness; numbness of an arm or leg; persistent or severe diarrhea; red, swollen, blistered, or peeling skin; severe stomach pain or swelling; severe tiredness or weakness; shortness of breath; signs of infection (fever, chills, persistent sore throat); sudden severe or persistent headache; swelling of the hands, feet, or legs; unusual bruising or bleeding; unusual vaginal bleeding; vision problems; vomit that looks like coffee grounds; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blood problems.

Proper storage of Y-90 Zevalin :

Y-90 Zevalin is usually handled and stored by a health care provider. If you are using Y-90 Zevalin at home, store Y-90 Zevalin as directed by your pharmacist or health care provider. Keep Y-90 Zevalin out of the reach of children and away from pets.

General information:

  • If you have any questions about Y-90 Zevalin , please talk with your doctor, pharmacist, or other health care provider.
  • Y-90 Zevalin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Y-90 Zevalin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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