23 . January , 2019 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Aztreonam

Big Image Pronouncation: (AZZ-TREE-oh-nam)
Class: Monobactam

Trade Names:
- Powder for injection (lyophilized cake) 500 mg (with approximately 780 mg L-arginine per gram aztreonam)
- Powder for injection (lyophilized cake) 1 g (with approximately 780 mg L-arginine per gram aztreonam)
- Powder for injection (lyophilized cake) 2 g (with approximately 780 mg L-arginine per gram aztreonam)
- Solution for injection 1 g per 50 mL
- Solution for injection 2 g per 50 mL

Mechanism of Action


Inhibits bacterial cell wall synthesis.




C max is 54 mcg/mL (500 mg dose), 90 mcg/mL (1 g dose); and 204 mcg/mL (2 g dose) immediately after administration.


T max is approximately 1 h; produces comparable serum concentrations to IV doses.


Vd is approximately 12.6 L; approximately 56% protein bound. Widely distributed to fluids and tissues, including CSF (inflamed meninges) and breast milk; crosses placenta.


The t ½ is approximately 1.7 h; serum clearance is 91 mL/min; renal clearance is 56 mL/min; 60% to 70% is recovered in the urine by 8 h; approximately 12% recovered in the feces.

Special Populations

Renal Function Impairment

Serum t ½ may be prolonged.

Hepatic Function Impairment

Serum t ½ may be prolonged.


Serum t ½ may be prolonged.

Indications and Usage

Treatment of infections of urinary tract, lower respiratory tract, skin and skin structure, intra-abdominal infections, gynecologic infections, surgical infections, and septicemia caused by susceptible microorganisms.

Unlabeled Uses

Treatment of acute, uncomplicated gonorrhea in patients with penicillin-resistant gonococci.


Standard considerations.

Dosage and Administration


IM/IV 500 mg or 1 g every 8 to 12 h.

Systemic Infections

IM/IV 1 to 2 g every 6 to 12 h.


IM/IV 30 to 50 mg/kg every 4 to 8 h.

Acute Uncomplicated Gonorrhea

IM 1 g. Max recommended dosage is 8 g/day.


Shake reconstituted solutions vigorously immediately after mixing. Reconstituted solutions not exceeding 2% are stable at room temperature for 48 h; stable under refrigeration for 7 days. Discard unused solutions. See the prescribing information for further storage and incompatibility information. Frozen infusion solutions may be stored for up to 3 mo at −4°F.

Drug Interactions

Beta-lactamase–inducing antibiotics (eg, cefoxitin, imipenem)

May antagonize activity of aztreonam and should not be used concurrently.


Nafcillin sodium, cephradine, and metronidazole are incompatible in admixture.

Laboratory Test Interactions


15% to 20% of patients had elevations of AST and ALT more than 3 times the ULN.

Adverse Reactions






Diarrhea; nausea; vomiting; pseudomembranous colitis.




Phlebitis/thrombophlebitis after IV administration; pain/swelling at IM injection site; fever.



Review culture and sensitivity of organism as available.


Category B .


Excreted in breast milk.


Safety and efficacy in children younger than 9 mo of age not established.


Reactions range from mild to life-threatening. Administer cautiously to penicillin- or cephalosporin-sensitive patients because of possible cross-reactivity.

Renal Function

Reduced dose required.


May result in overgrowth of nonsusceptible bacterial or fungal organisms.

Patient Information

  • Encourage patient to increase fluid intake to 2,000 to 3,000 mL/day, if allowed.
  • Inform patient to notify health care provider if rash or difficulty breathing is experienced.
  • If therapy is discontinued because of allergic reaction, explain significance of penicillin allergy and of potential problems with cephalosporins.
  • Caution patient against skipping doses or stopping treatment early, which could result in recurrence of symptoms and potential resistance of the organism to this product.

Recent Drug Updates at DrugIndexOnline:

Accolate Accolate
Generic Name: zafirlukast (za FIR loo cast) Brand Names: Accolate What is Accolate (zafirlukast)? Zafirlukast is a leukotriene (loo-koe-try-een) inhibitor. Leukotrienes are substances in the body that are associated with the inflammation and constriction of airway muscles and the accumu more...

Amoxapine Amoxapine
Generic Name: Amoxapine (a-MOX-a-peen) Brand Name: Generic only. No brands available. The RISK OF SUICIDAL THINKING AND BEHAVIOR was increased by antidepressants in short-term studies in children and adolescents with certain psychiatric disorders. Anyone considering the use of Amoxapine or any o more...

Angeliq Angeliq
Generic Name: drospirenone and estradiol (dro SPY re nown, ESS tra dy ol) Brand Names: Angeliq What is drospirenone and estradiol? Drospirenone is a female hormone that helps regulate ovulation and menstruation. Estradiol is a female hormone involved in development and maintenance of th more...

Cloxapen Cloxapen
Some commonly used brand names are: In the U.S.— Amoxil 1 Bactocill 11 Beepen-VK 13 Betapen-VK 13 Bicillin L-A 12 Cloxapen 5 Crysticillin 300 A.S. 12 Dynapen 6 Dycill 6 Geocillin 4 Geopen 4 Ledercillin VK 13 Mezlin 9 Nafcil 10 Nallpen 10 Omnipen 2 Omnipen-N 2 Pathocil 6 Pentids 12 Pen Vee more...

Copaxone injection Copaxone injection
Generic Name: glatiramer (injection) (gla TIR a mer) Brand Names: Copaxone What is glatiramer? Glatiramer is a combination of four amino acids (proteins) that affect the immune system. Glatiramer is used to prevent relapse of multiple sclerosis (MS). This medication will not cure MS, bu more...

Cortizone-5 Cortizone-5
Generic Name: hydrocortisone topical (hye droe KOR ti sone) Brand Names: Acticort 100, Aeroseb-HC, Ala-Cort, Aloe Cort, Aquanil HC, Beta HC, Caldecort, Cetacort, Cort-Dome, Cortaid, Cortane, Corticaine, Corticreme, Cortizone-10, Cortizone-5, Cotacort, Delcort, Dermacort, Dermarest Plus An more...

Eppy/N Ophthalmic Eppy/N Ophthalmic
Some commonly used brand names are: In the U.S.— Epifrin 1 Epinal 2 Eppy/N 2 Glaucon 1 In Canada— Epifrin 1 Note: For quick reference, the following medicines are numbered to match the corresponding brand names. This information applies to the following medicines: 1. more...

Kerlone Kerlone
Some commonly used brand names are: In the U.S.— Betapace 13 Blocadren 14 Cartrol 5 Corgard 8 Inderal 12 Inderal LA 12 Kerlone 3 Levatol 10 Lopressor 7 Normodyne 6 Sectral 1 Tenormin 2 Toprol-XL 7 Trandate 6 Visken 11 Zebeta 4 In Canada— Apo-Atenolol 2 Apo-Metoprolol 7 Apo-Metopro more...