19 . October , 2018 - Friday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Zalcitabine

Big Image

Generic name: Zalcitabine
Brand names: Hivid

Why is Zalcitabine prescribed?

Hivid is one of the drugs used against the human immunodeficiency virus (HIV)--the deadly cause of AIDS. HIV does its damage by slowly undermining the immune system, finally leaving the body without any defense against infection. Hivid staves off collapse of the immune system by interfering with the virus's ability to reproduce.

Hivid is often combined with a protease inhibitor (Crixivan, Invirase, and Norvir) as part of the "cocktail" of drugs that has proven so effective in halting or even reversing the progress of HIV. Hivid can also be combined with the HIV drug Retrovir, provided you have not already been taking Retrovir for more than 3 months. For people with advanced cases of HIV, Hivid is sometimes prescribed by itself when other drugs don't work or can't be tolerated.

Most important fact about Zalcitabine

Although Hivid can slow the progress of HIV, it is not a cure. You may continue to develop complications, including frequent infections. Even if you feel better, regular physical exams and blood counts by your doctor are highly advisable. Also be sure to notify your doctor immediately if you experience any changes in your general health.

How should you take Zalcitabine?

Hivid should be taken every 8 hours, exactly as prescribed. It is important to keep levels of the drug in your body as constant as possible, so be sure to take every scheduled dose. Never take more than the prescribed dose; nerve disorders could result.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at once.

--Storage instructions...

Store at room temperature in a tightly closed bottle.

What side effects may occur?

Although side effects can never be predicted, they are more likely--and more apt to be severe--in people with an advanced case of HIV. If any side effects develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Hivid.

  • More common side effects may include:
    Abdominal pain, fatigue, hives, itching, mouth sores and inflammation, nausea and vomiting, rash, tingling, burning, numbness, or pain in the hands and feet

There have been isolated reports of an extremely wide variety of additional problems occurring during Hivid therapy. Whether these problems were caused by the drug remains unclear. Nevertheless, it's wise to check with your doctor whenever any unexplained symptom develops.

Why should Zalcitabine not be prescribed?

If Hivid gives you an allergic reaction, you cannot use Zalcitabine.

Special warnings about Zalcitabine

If you have an advanced case of HIV, there is a one-in-three chance that Hivid will cause a serious nerve disorder called peripheral neuropathy. The first signs of this problem are numbness, tingling, and burning pain in the hands and feet. Check with your doctor as soon as any of these symptoms develop. If you continue to take Hivid, they will be followed by episodes of intense, sharp, shooting pain or severe, continuous, burning pain--and the condition could become irreversible. If Hivid is stopped promptly, the symptoms will gradually disappear.

Much more rarely, Hivid has been known to cause a dangerous inflammation of the pancreas (pancreatitis), especially in people who have previously had the problem. The chief signs are bouts of severe abdominal pain--usually lasting for days--accompanied by nausea and vomiting. If these symptoms develop, call your doctor without delay. Hivid therapy must be discontinued permanently.

Other rare but dangerous side effects to watch for include liver failure, weakening of the heart, and ulcers in the mouth and the canal to the stomach (esophagus). Kidney disease increases the risk of these side effects. If you've ever had kidney, liver, or heart problems, have hepatitis, or tend to abuse alcohol, be sure your doctor is aware of the situation. If you develop a liver problem, treatment with Hivid may have to be stopped.

Like other HIV drugs, Hivid sometimes causes a redistribution of body fat, resulting in added weight around the waist, a "buffalo hump" of fat on the upper back, breast enlargement, and wasting of the face, arms, and legs. It's not known why this occurs, or what long-term effects it might have.

Remember that Hivid does not eliminate HIV from the body. The infection can still be passed to others through sexual contact or blood contamination.

Possible food and drug interactions when taking Zalcitabine

A number of drugs can cause peripheral neuropathy and should not be taken with Hivid. The list includes:

Chloramphenicol (Chloromycetin)
Cisplatin (Platinol)
Dapsone
Disulfiram (Antabuse)
Ethionamide (Trecator-SC)
Glutethimide
Gold
Hydralazine
Iodoquinol (Yodoxin)
Isoniazid (Nydrazid)
Metronidazole (Flagyl)
Nitrofurantoin (Macrodantin)
Phenytoin (Dilantin)
Ribavirin (Virazole)
Vincristine (Oncovin)

Several other drugs should be either avoided or taken with caution while on Hivid therapy. Check with your doctor before taking the following:

Aminoglycoside antibiotics such as Garamycin
Amphotericin B (Fungizone)
Antacids containing magnesium and aluminum, including Maalox and Mylanta
Cimetidine (Tagamet)
Didanosine (Videx)
Foscarnet (Foscavir)
Lamivudine (Epivir)
Metoclopramide
Pentamidine (Pentam)
Probenecid

Special information if you are pregnant or breastfeeding

The safety of Hivid during pregnancy has not been adequately studied. Take contraceptive measures while using Hivid. If you are pregnant or plan to become pregnant, notify your doctor immediately.

Do not breastfeed your baby. HIV can be passed to an infant through breast milk.

Recommended dosage

ADULTS

The usual dose is one 0.750 milligram tablet every 8 hours. Your doctor may adjust the dosage if you have kidney problems. Hivid is recommended for use in combination with other HIV medications.

CHILDREN

Safety and effectiveness have not been established for children under 13.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Hivid overdose may include:
    Drowsiness, vomiting, numbness, tingling, burning, and pain in the arms and legs

Recent Drug Updates at DrugIndexOnline:





Adapalene Adapalene
Generic name: Adapalene Brand names: Differin Why is Adapalene prescribed? Differin is prescribed for the treatment of acne. Most important fact about Adapalene Differin makes your skin more sensitive to sunlight. While using this product, keep your exposure to the sun at a minimum, and protec more...

Amsacrine Amsacrine
Some commonly used brand names are: In Canada— AMSA P-D Other commonly used names are acridinyl anisidide and m-AMSA . * Not commercially available in the U.S. Category Antineoplastic Description Amsacrine (AM-sah-kreen) belongs to the general group of medicines known as antineop more...

Dovonex Dovonex
Generic name: Calcipotriene Brand names: Dovonex Why is Dovonex prescribed? Dovonex is prescribed to help clear up the scaly skin condition known as psoriasis. A synthetic form of vitamin D, it is available in cream and ointment form, and in a liquid for the scalp. Most important fact about Do more...

Glipizide and Metformin tablets Glipizide and Metformin tablets
Generic Name: Glipizide and Metformin hydrochloride) Dosage Form: Tablets Glipizide and Metformin Description Glipizide and Metformin hydrochloride tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes, glipizide, USP and metformin hydrochloride. Glipizide, U more...

Levsin SL Levsin SL
Generic Name: hyoscyamine (hye oh SYE a meen) Brand Names: Anaspaz, Cystospaz, Cystospaz-M, Levbid, Levsin, Levsin SL, Levsinex SR What is Levsin SL (hyoscyamine)? Hyoscyamine produces many effects in the body, including relief from muscle spasms. Hyoscyamine also reduces the fluid secr more...

Maxaquin Maxaquin
Generic name: Lomefloxacin hydrochloride Brand names: Maxaquin Why is Maxaquin prescribed? Maxaquin is a quinolone antibiotic used to treat lower respiratory infections, including chronic bronchitis, and urinary tract infections, including cystitis (inflammation of the inner lining of the bladde more...

P-V-Tussin Syrup P-V-Tussin Syrup
Generic Name: chlorpheniramine, hydrocodone, and pseudoephedrine (klor feh NEER ah meen, hye droe KOE doe N, sue do eh FEH drin) Brand Names: Atuss HD, Cordron-HC, Cordron-HC NR, Histinex PV, Hydrocof-HC, Hydron PCS, Hydrotuss HC, Hyphed, M-End, P-V-Tussin Syrup, Pediatex HC, Tussend What more...

PMS Nylidrin PMS Nylidrin
Some commonly used brand names are: In Canada— Arlidin Arlidin Forte PMS Nylidrin * Not commercially available in the U.S. Category Vasospastic therapy adjunct Description Nylidrin (NYE-li-drin) belongs to the group of medicines called vasodilators. Vasodilators increase the size more...