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All about: Acetaminophen/Dichloralphenazone/Isometheptene

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Generic Name: Acetaminophen/Dichloralphenazone/Isometheptene (a-seet-a-MIN-oh-fen/dye-klor-al-PHEN-a-zone/eye-soe-me-THEP-teen)
Brand Name: Examples include Duradrin and Midrin

Acetaminophen/Dichloralphenazone/Isometheptene is used for:

Treating certain types of headaches (tension, vascular). It may also be used to treat migraine headaches. It may also be used for other conditions as determined by your doctor.

Acetaminophen/Dichloralphenazone/Isometheptene is a combination analgesic, sedative, and sympathomimetic. It works by decreasing pain, providing sedation, and narrowing the blood vessels in the head and brain.

Do NOT use Acetaminophen/Dichloralphenazone/Isometheptene if:

  • you are allergic to any ingredient in Acetaminophen/Dichloralphenazone/Isometheptene
  • you have glaucoma, severe kidney problems, high blood pressure, heart problems, or liver problems
  • you are taking droxidopa or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Dichloralphenazone/Isometheptene :

Some medical conditions may interact with Acetaminophen/Dichloralphenazone/Isometheptene . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day
  • if you have liver or kidney problems, hepatitis, high blood pressure, heart problems, blood vessel problems (eg, blood vessels in your heart), or the blood disease porphyria
  • if you have had a recent heart attack

Some MEDICINES MAY INTERACT with Acetaminophen/Dichloralphenazone/Isometheptene . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone) or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Acetaminophen/Dichloralphenazone/Isometheptene 's side effects
  • Droxidopa because the risk of severe heart problems, including irregular heartbeat or heart attack, may be increased
  • Furazolidone or MAOIs (eg, phenelzine) because the risk of severe side effects, such as severe headache, high blood pressure, or high fever, may be increased
  • Isoniazid because the risk of liver problems may be increased
  • Anticoagulants (eg, warfarin) or bromocriptine because the risk of their side effects may be increased by Acetaminophen/Dichloralphenazone/Isometheptene
  • Guanadrel or guanethidine because their effectiveness may be decreased by Acetaminophen/Dichloralphenazone/Isometheptene

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Dichloralphenazone/Isometheptene may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Dichloralphenazone/Isometheptene :

Use Acetaminophen/Dichloralphenazone/Isometheptene as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Acetaminophen/Dichloralphenazone/Isometheptene by mouth with or without food.
  • For a migraine headache - Take Acetaminophen/Dichloralphenazone/Isometheptene at the first sign of a headache. If the initial dose does not relieve your headache, additional doses may be needed according to your doctor's instructions. Do not take a dose of Acetaminophen/Dichloralphenazone/Isometheptene within 60 minutes of your last dose. Do not take more than 5 capsules within a 12-hour period.
  • For a tension headache - Do not take more than 8 capsules within a 24-hour period.
  • If you miss a dose of Acetaminophen/Dichloralphenazone/Isometheptene and you still have a headache, take it as soon as you remember. If you need to take additional doses, continue to follow your doctor's dosing instructions. Do not take Acetaminophen/Dichloralphenazone/Isometheptene more often than directed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Dichloralphenazone/Isometheptene .

Important safety information:

  • Acetaminophen/Dichloralphenazone/Isometheptene may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Acetaminophen/Dichloralphenazone/Isometheptene with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Acetaminophen/Dichloralphenazone/Isometheptene has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Acetaminophen/Dichloralphenazone/Isometheptene may harm your liver. Your risk may be greater if you drink alcohol while you are using Acetaminophen/Dichloralphenazone/Isometheptene . Talk to your doctor before you take Acetaminophen/Dichloralphenazone/Isometheptene or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day.
  • Acetaminophen/Dichloralphenazone/Isometheptene may cause false results with some in-home test kits for blood cholesterol. Check with your doctor or pharmacist if you are taking Acetaminophen/Dichloralphenazone/Isometheptene and need to check your blood cholesterol at home.
  • Acetaminophen/Dichloralphenazone/Isometheptene should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Acetaminophen/Dichloralphenazone/Isometheptene while you are pregnant. Acetaminophen/Dichloralphenazone/Isometheptene is found in breast milk. If you are or will be breast-feeding while you use Acetaminophen/Dichloralphenazone/Isometheptene , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Acetaminophen/Dichloralphenazone/Isometheptene :

All medicines may cause side effects, but many people have no, or minor, side effects. If any of the following most COMMON side effects continue or become bothersome, check with your doctor: Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary dizziness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; unusual fatigue; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dark urine; excessive sweating; extreme fatigue; nausea and vomiting; stomach pain.

Proper storage of Acetaminophen/Dichloralphenazone/Isometheptene :

Store Acetaminophen/Dichloralphenazone/Isometheptene at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Dichloralphenazone/Isometheptene out of the reach of children and away from pets.

General information:

  • If you have any questions about Acetaminophen/Dichloralphenazone/Isometheptene , please talk with your doctor, pharmacist, or other health care provider.
  • Acetaminophen/Dichloralphenazone/Isometheptene is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Acetaminophen/Dichloralphenazone/Isometheptene . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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