21 . January , 2018 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Bacitracin Zinc/Polymyxin B Sulfate

Big Image Pronouncation: (Bass-ih-TRAY-sin zingk/pal-ee-MIX-in BEE SULL-fate)
Class: Antibiotic

Trade Names:
Polysporin
- Ophthalmic ointment 500 units/g bacitracin zinc and 10,000 units/g polymyxin B sulfate

Trade Names:
AK-Poly-Bac
- Ophthalmic ointment 500 units/g bacitracin zinc and 10,000 units/g polymyxin B sulfate

Optimyxin Ointment (Canada)

Mechanism of Action

Pharmacology

Polymyxin B

Interacts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.

Bacitracin

Interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with peptidoglycan synthesis.

Indications and Usage

Treatment of superficial ocular infections, involving the conjunctiva and/or cornea, caused by susceptible organisms.

Contraindications

Standard considerations.

Dosage and Administration

Ophthalmic Apply every 3 or 4 h for 7 to 10 days, depending on severity of infection.

General Advice

  • For ophthalmic use only. Not for use on the skin.
  • If using other topical ophthalmic medications, instill drops first, wait at least 5 min, and instill ointment last.

Storage/Stability

Store at controlled room temperature (59° to 86°F). Keep tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Miscellaneous

Itching; swelling; eye redness; eye irritation; allergic reaction.

Precautions

Monitor

Notify health care provider if eye or eyelid inflammation is noted, or if symptoms do not improve or worsen.


Pregnancy

Bacitracin

Category C .

Polymyxin B

Category B .

Lactation

Undetermined.

Superinfection

Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Corneal healing

Corneal healing may be retarded.

Patient Information

  • Review prescribed dosing schedule with patient, family, or caregiver.
  • Remind patient, family, or caregiver that ointment is for use in eye only.
  • Teach patient, family, or caregiver proper technique for instilling ointment: wash hands; do not allow tip of tube to touch eye, eyelid, fingers, or any other surface. Tilt head back, look up; pull lower eyelid down to form pocket; place prescribed amount of ointment in pocket. Look downward before closing eye. Do not rub eye.
  • Advise patient, family, or caregiver that if more than 1 topical ophthalmic drug is being used, instill eye drops first, wait at least 5 min, and then instill ointment last.
  • Inform patient that temporary blurred vision and stinging of eye are most common adverse reactions and to contact a health care provider if adverse reactions occur and are bothersome.
  • Advise patient to contact an eye doctor if eye or eyelid inflammation is noted, or if eye symptoms do not improve or worsen.
  • Advise patient that the entire course of therapy must be completed to ensure max benefit and to complete full course of therapy even if symptoms have resolved.
  • Instruct patient not to wear contact lenses during treatment.

Recent Drug Updates at DrugIndexOnline:





Anti-Thymocyte Globulin (Rabbit) Anti-Thymocyte Globulin (Rabbit)
Generic Name: Anti-Thymocyte Globulin (Rabbit) (AN-tye THYE-moe-site GLOB-yoo-lin) Brand Name: ThymoglobulinAnti-Thymocyte Globulin (Rabbit) should only be given by a doctor in a medical setting under the supervision of a doctor who is experienced in management of organ transplant patients. Ant more...

Chlorthalidone Chlorthalidone
Generic Name: Chlorthalidone (klor-THAL-ih-dohn) Brand Name: ThalitoneChlorthalidone is used for:Treating high blood pressure. It may be used along with other medicines to treat fluid retention caused by certain conditions (eg, heart failure, liver or kidney problems) or medicines (eg, corticos more...

Citalopram Citalopram
Generic Name: Citalopram hydrobromide Dosage Form: Tablets Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MD more...

Exdol Exdol
Some commonly used brand names are: In the U.S.— Aceta Elixir 1 Aceta Tablets 1 Acetaminophen Uniserts 1 Actamin 1 Actamin Extra 1 Actamin Super 2 Aminofen 1 Aminofen Max 1 Apacet Capsules 1 Apacet Elixir 1 Apacet Extra Strength Caplets 1 Apacet Extra Strength Tablets 1 Apacet, Infants' 1 more...

Fluorometholone Acetate Suspension Fluorometholone Acetate Suspension
Generic Name: Fluorometholone Acetate Ophthalmic Suspension (flure-oh-METH-oh-lone) Brand Name: FlarexFluorometholone Acetate Suspension is used for:Treating inflammation (swelling, warmth, redness, pain) of the eyes and eyelids. Fluorometholone Acetate Suspension is a corticosteroid. Exactly ho more...

Fortovase Fortovase
Generic name: Saquinavir Brand names: Invirase, Fortovase Why is Fortovase prescribed? Fortovase is used in the treatment of advanced human immunodeficiency virus (HIV) infection. HIV causes the immune system to break down so that it can no longer fight off other infections. This leads to the fa more...

Hydrocodone and Ibuprofen Hydrocodone and Ibuprofen
Generic Name: hydrocodone bitartrate and ibuprofen Dosage Form: Tablets BOXED WARNING Cardiovascular Risk NSAIDs11 may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patien more...

Nesiritide Nesiritide
Generic Name: Nesiritide (ni-SIR-i-tide) Brand Name: NatrecorNesiritide is used for:Treating patients with congestive heart failure who have difficulty breathing during rest or with minimal activity. Nesiritide is a human B type natriuretic peptide (hBNP). It works by binding to certain recept more...