21 . May , 2018 - Monday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Bacitracin Zinc/Polymyxin B Sulfate

Big Image Pronouncation: (Bass-ih-TRAY-sin zingk/pal-ee-MIX-in BEE SULL-fate)
Class: Antibiotic

Trade Names:
Polysporin
- Ophthalmic ointment 500 units/g bacitracin zinc and 10,000 units/g polymyxin B sulfate

Trade Names:
AK-Poly-Bac
- Ophthalmic ointment 500 units/g bacitracin zinc and 10,000 units/g polymyxin B sulfate

Optimyxin Ointment (Canada)

Mechanism of Action

Pharmacology

Polymyxin B

Interacts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.

Bacitracin

Interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with peptidoglycan synthesis.

Indications and Usage

Treatment of superficial ocular infections, involving the conjunctiva and/or cornea, caused by susceptible organisms.

Contraindications

Standard considerations.

Dosage and Administration

Ophthalmic Apply every 3 or 4 h for 7 to 10 days, depending on severity of infection.

General Advice

  • For ophthalmic use only. Not for use on the skin.
  • If using other topical ophthalmic medications, instill drops first, wait at least 5 min, and instill ointment last.

Storage/Stability

Store at controlled room temperature (59° to 86°F). Keep tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Miscellaneous

Itching; swelling; eye redness; eye irritation; allergic reaction.

Precautions

Monitor

Notify health care provider if eye or eyelid inflammation is noted, or if symptoms do not improve or worsen.


Pregnancy

Bacitracin

Category C .

Polymyxin B

Category B .

Lactation

Undetermined.

Superinfection

Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Corneal healing

Corneal healing may be retarded.

Patient Information

  • Review prescribed dosing schedule with patient, family, or caregiver.
  • Remind patient, family, or caregiver that ointment is for use in eye only.
  • Teach patient, family, or caregiver proper technique for instilling ointment: wash hands; do not allow tip of tube to touch eye, eyelid, fingers, or any other surface. Tilt head back, look up; pull lower eyelid down to form pocket; place prescribed amount of ointment in pocket. Look downward before closing eye. Do not rub eye.
  • Advise patient, family, or caregiver that if more than 1 topical ophthalmic drug is being used, instill eye drops first, wait at least 5 min, and then instill ointment last.
  • Inform patient that temporary blurred vision and stinging of eye are most common adverse reactions and to contact a health care provider if adverse reactions occur and are bothersome.
  • Advise patient to contact an eye doctor if eye or eyelid inflammation is noted, or if eye symptoms do not improve or worsen.
  • Advise patient that the entire course of therapy must be completed to ensure max benefit and to complete full course of therapy even if symptoms have resolved.
  • Instruct patient not to wear contact lenses during treatment.

Recent Drug Updates at DrugIndexOnline:





Ammonium Lactate/Pramoxine Cream Ammonium Lactate/Pramoxine Cream
Generic Name: Ammonium Lactate/Pramoxine Cream (ah-MOE-nee-uhm LACK-tate/pra-MOX-een) Brand Name: AmLactin APAmmonium Lactate/Pramoxine Cream is used for:Treating itching due to dry skin and other minor skin irritations. Ammonium Lactate/Pramoxine Cream is a combination moisturizer and local ane more...

Estrasorb Emulsion Estrasorb Emulsion
Generic Name: Estradiol Topical Emulsion (ES-tra-DYE-ol) Brand Name: Estrasorb Estrasorb Emulsion should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious more...

Fludrocortisone Fludrocortisone
Generic Name: Fludrocortisone acetate Dosage Form: Tablets, usp Revised MAY 2001 1009970101 Rx only Description: Fludrocortisone Acetate Tablets, USP contains Fludrocortisone acetate, a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid a more...

Fuzeon Fuzeon
Generic Name: Enfuvirtide (en-FEW-ver-tide) Brand Name: FuzeonFuzeon is used for:Treating HIV infection in combination with other anti-HIV medicines. Fuzeon is an antiviral agent. It works by blocking HIV from infecting healthy immune cells (CD4 cells). Do NOT use Fuzeon if:you are allergic t more...

Niacin And Lovastatin Niacin And Lovastatin
Some commonly used brand names are: In the U.S.— Advicor Other commonly used names for niacin are nicotinic acid or vitamin B3 . † Not commercially available in Canada. Category Antihyperlipidemic Description Niacin extended-release and Lovastatin (NYE-a-sin and LOE-va-sta more...

Panlor Panlor
Some commonly used brand names are: In the U.S.— Allay 4 Anexsia 5/500 4 Anexsia 7.5/650 4 Anolor DH 5 4 Bancap-HC 4 Capital with Codeine 1 Co-Gesic 4 Darvocet-N 50 7 Darvocet-N 100 7 DHCplus 3 Dolacet 4 Dolagesic 4 Duocet 4 E-Lor 7 Endocet 5 EZ III 1 Hycomed 4 Hyco-Pap 4 Hydrocet 4 Hydro more...

Piloptic-6 Piloptic-6
Generic Name: pilocarpine ophthalmic (pie low CAR peen) Brand Names: Akarpine, Ocusert, Pilagan with C Cap, Pilocar, Pilopine-HS, Piloptic-1, Piloptic-1/2, Piloptic-2, Piloptic-3, Piloptic-4, Piloptic-6, Pilostat What is Piloptic-6 (pilocarpine ophthalmic)? Pilocarpine ophthalmic reduce more...

Pravigard Pac Pravigard Pac
Generic Name: aspirin and pravastatin (AS pir in and prah vah STAH tin) Brand Names: Pravigard Pac What is aspirin and pravastatin? Aspirin is in a class of drugs called salicylates. It works by reducing substances in the body that cause pain and inflammation. Aspirin also reduces the fo more...