22 . March , 2019 - Friday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Bacitracin Zinc/Polymyxin B Sulfate

Big Image Pronouncation: (Bass-ih-TRAY-sin zingk/pal-ee-MIX-in BEE SULL-fate)
Class: Antibiotic

Trade Names:
Polysporin
- Ophthalmic ointment 500 units/g bacitracin zinc and 10,000 units/g polymyxin B sulfate

Trade Names:
AK-Poly-Bac
- Ophthalmic ointment 500 units/g bacitracin zinc and 10,000 units/g polymyxin B sulfate

Optimyxin Ointment (Canada)

Mechanism of Action

Pharmacology

Polymyxin B

Interacts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.

Bacitracin

Interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with peptidoglycan synthesis.

Indications and Usage

Treatment of superficial ocular infections, involving the conjunctiva and/or cornea, caused by susceptible organisms.

Contraindications

Standard considerations.

Dosage and Administration

Ophthalmic Apply every 3 or 4 h for 7 to 10 days, depending on severity of infection.

General Advice

  • For ophthalmic use only. Not for use on the skin.
  • If using other topical ophthalmic medications, instill drops first, wait at least 5 min, and instill ointment last.

Storage/Stability

Store at controlled room temperature (59° to 86°F). Keep tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Miscellaneous

Itching; swelling; eye redness; eye irritation; allergic reaction.

Precautions

Monitor

Notify health care provider if eye or eyelid inflammation is noted, or if symptoms do not improve or worsen.


Pregnancy

Bacitracin

Category C .

Polymyxin B

Category B .

Lactation

Undetermined.

Superinfection

Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Corneal healing

Corneal healing may be retarded.

Patient Information

  • Review prescribed dosing schedule with patient, family, or caregiver.
  • Remind patient, family, or caregiver that ointment is for use in eye only.
  • Teach patient, family, or caregiver proper technique for instilling ointment: wash hands; do not allow tip of tube to touch eye, eyelid, fingers, or any other surface. Tilt head back, look up; pull lower eyelid down to form pocket; place prescribed amount of ointment in pocket. Look downward before closing eye. Do not rub eye.
  • Advise patient, family, or caregiver that if more than 1 topical ophthalmic drug is being used, instill eye drops first, wait at least 5 min, and then instill ointment last.
  • Inform patient that temporary blurred vision and stinging of eye are most common adverse reactions and to contact a health care provider if adverse reactions occur and are bothersome.
  • Advise patient to contact an eye doctor if eye or eyelid inflammation is noted, or if eye symptoms do not improve or worsen.
  • Advise patient that the entire course of therapy must be completed to ensure max benefit and to complete full course of therapy even if symptoms have resolved.
  • Instruct patient not to wear contact lenses during treatment.

Recent Drug Updates at DrugIndexOnline:





Diupres-250 Diupres-250
Generic Name: chlorothiazide and reserpine (klor oh THYE a zide and re SER peen) Brand Names: Diupres-250, Diupres-500 What is Diupres-250 (chlorothiazide and reserpine)? Reserpine lowers blood pressure by decreasing the amount of certain chemicals in your body. This allows your blood v more...

Divigel 1 mg/packet for use on skin Divigel 1 mg/packet for use on skin
Generic Name: estradiol topical (for use on skin) (ess tra DYE ol TOP ik al) Brand Names: Divigel 1 mg/packet, Elestrin, Estrasorb, Estrogel What is estradiol topical? Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body. Estradiol topical is u more...

Erythromycin Ethylsuccinate Erythromycin Ethylsuccinate
Generic Name: Erythromycin Ethylsuccinate Tablets (eh-RITH-roe-MYE-sin) Brand Name: E. E. S. 400Erythromycin Ethylsuccinate is used for:Treating infections caused by certain bacteria or amoebas. It may also be used to prevent attacks of rheumatic fever in patients who are unable to use other me more...

heparin heparin
Generic Name: heparin (HEP a rin) Brand Names: What is heparin? Heparin is an anticoagulant (blood thinner) that prevents the formation of blood clots. Heparin is used to treat and prevent blood clots in the veins, arteries, or lung. Heparin is also used before surgery to reduce the ri more...

Hydralazine Hydrochloride Hydralazine Hydrochloride
Pronouncation: (high-DRAL-uh-zeen HIGH-droe-KLOR-ide) Class: Peripheral vasodilator Trade Names: Apresoline - Tablets 25 mg - Tablets 50 mg - Tablets 100 mg - Injection 20 mg/mL Apo-Hydralazine (Canada) Novo-Hylazin (Canada) Nu-Hydral (Canada) Mechanism of Action Pharmacology Directly relaxes vascu more...

multivitamins with iron multivitamins with iron
Generic Name: multivitamins with iron (mull tee VYE tah mins with i ron) Brand Names: Allbee-C 800 with Iron, Anemagen, Anemagen FA, Bugs Bunny with Iron Chewable, Chromatinic, Contrin, Dayalets Plus Iron, Diatx Fe, Equi-Roca Plus, Equicyte Plus, Fe-Tinic 150 Forte, Femiron Multi with Iro more...

Optiray 160 Optiray 160
Generic Name: ioversol (eye oh VERS ol) Brand Names: Optiray 160, Optiray 240, Optiray 300, Optiray 320, Optiray 350 What is Optiray 160 (ioversol)? Ioversol is in a group of drugs called radiopaque (RAY dee oh payk) contrast agents. Ioversol contains iodine, a substance that absorbs x more...

Polydine Solution Polydine Solution
Generic Name: Povidone/Iodine Solution (POE-vi-done/EYE-oh-dine) Brand Name: Examples include Minidyne and PolydinePolydine Solution is used for:Treating minor wounds and infections, as well as killing bacteria. Polydine Solution is an antiseptic combination. It works by killing sensitive bacte more...