20 . October , 2018 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Bumetanide

Big Image Pronouncation: (BYOO-MET-uh-nide)
Class: Loop diuretic

Trade Names:
Bumex
- Tablets 0.5 mg
- Tablets 1 mg
- Tablets 2 mg
- Injection 0.25 mg/mL

Burinex (Canada)

Mechanism of Action

Pharmacology

Inhibits reabsorption of sodium and chloride in proximal tubules and loop of Henle.

Pharmacokinetics

Distribution

Bumetanide is 72% to 96% protein bound.

Metabolism

Oxidation of the N-butyl side chain.

Elimination

The t ½ is 60 to 90 min; 81% is excreted in urine, 45% as unchanged drug, and 2% in bile.

Onset

Oral

30 to 60 min.

IV

Within minutes.

Peak

Oral

1 to 2 h.

IV

15 to 30 min.

Duration

Oral

4 to 6 h.

Special Populations

Renal Function Impairment

The t ½ is prolonged.

Children

Elimination is considerably slower in neonates.

Indications and Usage

Treatment of edema associated with CHF, hepatic cirrhosis, and renal disease.

Unlabeled Uses

Relief of adult nocturia.

Contraindications

Hypersensitivity to other loop diuretics or to sulfonylureas; anuria; hepatic coma or states of severe electrolyte depletion until condition is improved or corrected.

Dosage and Administration

Adults

PO 0.5 to 2 mg/day as single dose. If inadequate response, give second or third dose at 4 to 5 h intervals up to max 10 mg/day.

IM/IV 0.5 to 1 mg/day over 1 to 2 min. May repeat at 2- to 3-h intervals, up to max 10 mg/day. Reserve parenteral route for situations in which GI absorption is impaired or when oral administration is not practical; replace with oral therapy as soon as possible.

Storage/Stability

If given by IV infusion, use solution within 24 h of preparation. Store at room temperature in tightly closed container.

Drug Interactions

Aminoglycosides

Increased auditory toxicity.

Cisplatin

Additive ototoxicity.

Digitalis glycosides

Electrolyte disturbances may predispose to digitalis-induced arrhythmias.

Lithium

Increased plasma lithium levels and toxicity.

NSAIDs

Decreased effects of bumetanide.

Salicylates

Impaired diuretic response in patients with cirrhosis and ascites.

Thiazide diuretics

Synergistic effects that may result in profound diuresis and serious electrolyte abnormalities.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Hypotension; ECG changes; chest pain.

CNS

Asterixis; encephalopathy with pre-existing liver disease; vertigo; headache; dizziness.

Dermatologic

Hives; pruritus; itching; nipple tenderness; rash; photosensitivity.

EENT

Impaired hearing; ear discomfort; tinnitus; deafness.

GI

Upset stomach; dry mouth; nausea; vomiting; diarrhea; pain.

Genitourinary

Premature ejaculation; difficulty maintaining erection; renal failure.

Hematologic

Thrombocytopenia; deviations in Hgb, Hct, prothrombin time and WBC, platelets, and differential counts.

Metabolic

Glucosuria and proteinuria; hyperuricemia; gout; hypochloremia; hypokalemia; azotemia; hyponatremia; increased serum creatinine; hyperglycemia; variations in phosphorus, CO 2 content, bicarbonate, and calcium; increases in LDL, total cholesterol, and triglycerides; decreases in HDL cholesterol.

Respiratory

Hyperventilation.

Miscellaneous

Musculoskeletal weakness; arthritic pain; pain; muscle cramps; fatigue; dehydration; sweating.

Precautions

Warnings

Excessive amounts may cause profound diuresis and water/electrolyte depletion. Careful medical supervision required with dosage adjustment and schedule to individual patient need.


Monitor

Check that baseline creatine, BUN, calcium, uric acid, and CBC have been obtained before beginning therapy and monitor throughout therapy. Observe for ototoxicity, especially in patients receiving drug via IV infusion and in those taking other ototoxic drugs. If tinnitus, hearing impairment, or fullness in ears is reported, notify health care provider.


Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established in children under 18 yr of age.

Renal Function

In severe chronic renal insufficiency, patients may benefit from continuous infusion (12 mg over 12 h), rather than from intermittent bolus therapy. Monitor renal function and discontinue drug if renal function decreases further.

Dehydration

Excessive diuresis may cause dehydration and decreased blood volume with circulatory collapse and possible vascular thrombosis and embolism, especially in elderly patients.

Hepatic cirrhosis and ascites

Sudden alterations of electrolyte balance may precipitate hepatic encephalopathy and coma.

Ototoxicity

Associated with rapid injection, very large doses or concurrent use of other ototoxic drugs.

Systemic lupus erythematosus

May be exacerbated or activated.

Overdosage

Symptoms

Profound water loss, volume and electrolyte depletion (characterized by weakness, dizziness, mental confusion, anorexia, lethargy, vomiting, cramps), dehydration, reduction in blood volume, circulatory collapse with possible thrombosis and embolism.

Patient Information

  • Instruct patient to take as single dose early in day. Drug can be taken with food or milk to reduce GI upset.
  • Advise patient to drink adequate fluids to prevent dehydration unless fluid restrictions apply.
  • Caution patient to get out of bed slowly on arising, and to avoid sudden position changes to prevent orthostatic hypotension.
  • If patient is not taking a potassium supplement, advise patient to increase potassium-rich foods in daily diet.
  • Instruct patient to report the following symptoms to health care provider: signs of bleeding, weakness, cramps, nausea or dizziness.
  • Caution patient to avoid exposure to sunlight, and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
  • Advise diabetic patients to monitor blood glucose carefully because drug may cause loss of glycemic control.

Recent Drug Updates at DrugIndexOnline:





Crysti-12 Crysti-12
Some commonly used brand names are: In the U.S.— Alphamin 2 Cobex 1 Cobolin-M 1 Crystamine 1 Crysti-12 1 Cyanoject 1 Cyomin 1 Hydrobexan 2 Hydro-Cobex 2 Hydro-Crysti-12 2 Hydroxy-Cobal 2 LA-12 2 Neuroforte-R 1 Nascobal 1 Primabalt 1 Rubramin PC 1 Shovite 1 Vibal 1 Vibal LA 2 Vitabee 12 1 more...

Despec Despec
Some commonly used brand names are: In the U.S.— Alka-Seltzer Plus Cold and Cough 21 Alka-Seltzer Plus Cold and Cough Medicine Liqui-Gels 34 Alka-Seltzer Plus Night-Time Cold Liqui-Gels 35 Ami-Tex LA 69 Anatuss LA 70 Benylin Expectorant 54 Bromfed-DM 17 Broncholate 68 Carbinoxamine Compou more...

E.E.S.-400 E.E.S.-400
Generic Name: erythromycin (eer ith roe MYE sin) Brand Names: E-Mycin, E.E.S.-200, E.E.S.-400, Ery-Tab, Eryc, EryPed, Erythrocin Stearate Filmtab, Erythrocot, Ilosone, MY-E, PCE Dispertab, Robimycin What is E.E.S.-400 (erythromycin)? Erythromycin is in a group of drugs called macrolide more...

Feiba VH injectable Feiba VH injectable
Generic Name: anti-inhibitor coagulant complex (injectable) (an TEE in HIH bih tor coe AG you lant COM plex) Brand Names: Autoplex T, Feiba VH What is anti-inhibitor coagulant complex? Anti-inhibitor coagulant complex is made up of proteins normally present in the blood that allow the bl more...

Fluconazole Fluconazole
Generic Name: Fluconazole Tablets (flue-KON-a-zole) Brand Name: DiflucanFluconazole is used for:Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor. Fluconazole is an azole antifungal. It kills sensitive fungi by in more...

hydralazine and isosorbide dinitrate hydralazine and isosorbide dinitrate
Generic Name: hydralazine and isosorbide dinitrate (hi dral LA zeen and I so zor bi da din eye treyt) Brand Names: BiDil What is hydralazine and isosorbide dinitrate? Hydralazine is a vasodilator. It relaxes (widens) veins and arteries, which makes it easier for your heart to pump. Isoso more...

Laxit Rectal Laxit Rectal
Some commonly used brand names are: In the U.S.— Bisco-Lax 1 Ceo-Two 5 Dacodyl 1 Deficol 1 Dulcolax 1 Fleet Babylax 3 Fleet Bisacodyl 1 Fleet Enema 7 Fleet Enema for Children 7 Fleet Enema Mineral Oil 4 Fleet Glycerin Laxative 3 Fleet Laxative 1 Sani-Supp 3 Senokot 6 Theralax 1 Therevac P more...

Prevacid Delayed -Release Orally Disintegrating Tablets Prevacid Delayed -Release Orally Disintegrating Tablets
Generic Name: Lansoprazole Orally Disintegrating Tablets (lan-SOE-pra-zole) Brand Name: Prevacid SoluTabPrevacid Delayed -Release Orally Disintegrating Tablets is used for:Preventing or treating certain types of ulcers. It is also used to treat symptoms of gastroesophageal reflux disease (GERD) more...