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All about: Buphenyl

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Generic Name: Sodium Phenylbutyrate Tablets (SOE-dee-um fen-il-BYOO-ti-rate)
Brand Name: Buphenyl

Buphenyl is used for:

Treating urea cycle (nitrogen or ammonia excretion) disorders along with a prescribed diet.

Buphenyl is a nutritional modifier. It works by helping rid the body of excess nitrogen waste by bypassing the urea cycle.

Do NOT use Buphenyl if:

  • you are allergic to any ingredient in Buphenyl
  • you have sudden high levels of ammonia in the blood

Contact your doctor or health care provider right away if any of these apply to you.

Before using Buphenyl :

Some medical conditions may interact with Buphenyl . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have edema (swelling or water retention), heart failure or other heart problems, high blood pressure, or kidney or liver disease

Some MEDICINES MAY INTERACT with Buphenyl . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Corticosteroids (eg, prednisone), haloperidol, or valproic acid because these medicines increase blood ammonia levels
  • Probenecid because the actions and side effects of Buphenyl may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Buphenyl may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Buphenyl :

Use Buphenyl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Buphenyl with meals.
  • It is very important that your full dose for a 24-hour period is taken. The total daily dose should be taken in equally divided amounts (3 to 6 times per day).
  • It is very important to follow the prescribed diet given to you by your doctor.
  • Buphenyl comes with an additional patient information sheet. Read it carefully and reread it each time you get Buphenyl refilled.
  • If you miss a dose of Buphenyl , take it as soon as possible that same day.

Ask your health care provider any questions you may have about how to use Buphenyl .

Important safety information:

  • Wear a MedicAlert tag that states that you have a urea cycle disorder.
  • LAB TESTS, such as blood tests for ammonia and amino acid levels, will be required to monitor your progress. Be sure to keep all doctor and lab appointments.
  • Buphenyl is not recommended for use in CHILDREN weighing less than 44 pounds (20 kg). Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Buphenyl causes harm to the developing fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Buphenyl during pregnancy. It is unknown if Buphenyl is excreted in breast milk. If you are or will be breast-feeding while taking Buphenyl , consult your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Buphenyl :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; body odor; decreased appetite; absent or irregular menstrual periods.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased hearing; disorientation; headache; lightheadedness; memory problems; sleepiness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Buphenyl :

Store Buphenyl between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. After opening, keep the bottle tightly closed. Do not store in the bathroom. Keep Buphenyl out of the reach of children and away from pets.

General information:

  • If you have any questions about Buphenyl , please talk with your doctor, pharmacist, or other health care provider.
  • Buphenyl is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Buphenyl . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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