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All about: Captopril/Hydrochlorothiazide

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Generic Name: Captopril/Hydrochlorothiazide (KAP-toe-prill/hye-droe-klor-oh-THYE-a-zide)
Brand Name: Capozide

When used after the third month of pregnancy, Captopril/Hydrochlorothiazide can cause injury and even death to the developing fetus. If you become pregnant or think you may be pregnant, stop taking Captopril/Hydrochlorothiazide and contact your doctor at once.


Captopril/Hydrochlorothiazide is used for:

Treating high blood pressure. It may also be for other conditions as determined by your doctor.

Captopril/Hydrochlorothiazide is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works by decreasing a chemical that tightens blood vessels and by helping the kidneys eliminate extra fluid from the body. This causes blood vessels to relax (dilate) and decreases excess fluid, which lowers blood pressure.

Do NOT use Captopril/Hydrochlorothiazide if:

  • you are allergic to any ingredient in Captopril/Hydrochlorothiazide
  • you are in the second or third trimester of pregnancy
  • you have had a severe allergic reaction (eg, rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to any other ACE inhibitor (eg, enalapril) or to any other sulfonamide medicine (eg, acetazolamide, glyburide, sulfamethoxazole)
  • you are taking dextran sulfate, dofetilide, or ketanserin
  • you are unable to urinate

Contact your doctor or health care provider right away if any of these apply to you.

Before using Captopril/Hydrochlorothiazide :

Some medical conditions may interact with Captopril/Hydrochlorothiazide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of swelling of the hands, feet, eyes, lips, tongue, or throat; bone marrow problems; blood vessel problems of the heart or brain; kidney disease, transplant, or dialysis; heart problems; liver problems; or parathyroid problems
  • if you have a history of blood electrolyte problems (eg, high or low potassium, sodium, chloride, magnesium, or calcium), an autoimmune disease (eg, lupus), thickening of the skin, gout, diabetes, asthma, or high blood cholesterol or lipid levels, or you are on a sodium-restricted diet

Some MEDICINES MAY INTERACT with Captopril/Hydrochlorothiazide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Barbiturates (eg, phenobarbital), beta-blockers (eg, propranolol), corticosteroids (eg, prednisone), diazoxide, monoamine oxidase (MAO) inhibitors (eg, phenelzine), narcotic pain medicines (eg, codeine, fentanyl, morphine), or other medicines for high blood pressure because side effects of Captopril/Hydrochlorothiazide may be increased
  • Amphotericin B, calcium supplements, corticosteroids (eg, prednisone), corticotropin (ACTH), digoxin, dofetilide, ketanserin, loop diuretics (eg, furosemide), potassium-sparing diuretics (eg, spironolactone), potassium supplements, or thiopurines (eg, azathioprine) because the risk of serious side effects including kidney problems, electrolyte problems, irregular heartbeat, and anemia may be increased
  • Cholestyramine, colestipol, or salicylates (eg, aspirin) because they may decrease Captopril/Hydrochlorothiazide 's effectiveness
  • Dextran sulfate because it may increase the risk of allergic reactions, and severe dizziness or lightheadedness may be increased
  • Lithium because the risk of toxic effects, including seizures, may be increased by Captopril/Hydrochlorothiazide
  • Anticoagulants (eg, warfarin), insulin, methenamine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin), pressor amines (eg, norepinephrine), probenecid, sulfinpyrazone, and sulfonylureas (eg, glyburide) because effectiveness may be decreased by Captopril/Hydrochlorothiazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Captopril/Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Captopril/Hydrochlorothiazide :

Use Captopril/Hydrochlorothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Captopril/Hydrochlorothiazide by mouth on an empty stomach 1 hour before meals.
  • Captopril/Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • Captopril/Hydrochlorothiazide works best if it is taken at the same time each day.
  • Continue to use Captopril/Hydrochlorothiazide even if you feel well. Do not miss any doses.
  • If you miss a dose of Captopril/Hydrochlorothiazide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Captopril/Hydrochlorothiazide .

Important safety information:

  • Captopril/Hydrochlorothiazide may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Captopril/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Captopril/Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Tell your doctor or dentist that you take Captopril/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not take additional potassium or change your diet to include more potassium without first checking with your doctor.
  • Captopril/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Captopril/Hydrochlorothiazide . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Captopril/Hydrochlorothiazide may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients - Captopril/Hydrochlorothiazide may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Captopril/Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • LAB TESTS, including blood pressure monitoring, blood potassium or other electrolyte levels, and urine tests, may be performed while you use Captopril/Hydrochlorothiazide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Captopril/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Captopril/Hydrochlorothiazide may cause fetal and newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Captopril/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Captopril/Hydrochlorothiazide .

Possible side effects of Captopril/Hydrochlorothiazide :

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; dizziness or lightheadedness when sitting or standing quickly; drowsiness; fatigue; headache; nausea; taste changes; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; confusion; decrease in amount of urine; difficulty swallowing; fainting; fever or sore throat; joint pain; muscle pain, cramps, or tremors; restlessness; seizures; slow, fast, or irregular heartbeat; stomach pain; unusually dry mouth; unusual thirst; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; dry mouth; excessive urination followed by a decrease in amount of urine; lightheadedness, especially upon standing; muscle cramps; weakness; weak or irregular heartbeat.

Proper storage of Captopril/Hydrochlorothiazide :

Store Captopril/Hydrochlorothiazide at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Keep the bottle tightly closed. Do not store in the bathroom. Keep Captopril/Hydrochlorothiazide out of the reach of children and away from pets.

General information:

  • If you have any questions about Captopril/Hydrochlorothiazide , please talk with your doctor, pharmacist, or other health care provider.
  • Captopril/Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Captopril/Hydrochlorothiazide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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