15 . December , 2018 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Cefadroxil

Big Image Pronouncation: (SEFF-uh-DROX-ill)
Class: Antibiotic, Cephalosporin

Trade Names:
Duricef
- Capsules 500 mg (as monohydrate)
- Tablets 1 g (as monohydrate)
- Powder for Oral Suspension 125 mg/5 mL
- Powder for Oral Suspension 250 mg/5 mL
- Powder for Oral Suspension 500 mg/5 mL

Apo-Cefadroxil (Canada)
Novo-Cefadroxil (Canada)

Mechanism of Action

Pharmacology

Inhibits mucopeptide synthesis in bacterial cell wall.

Pharmacokinetics

Absorption

Rapidly absorbed. C max is about 16 mcg/mL (500 mg dose) and 28 mcg/mL (1,000 mg dose).

Distribution

20% protein bound.

Elimination

More than 90% is excreted in the urine as unchanged drug within 24 h; t ½ is 78 to 96 min.

Special Populations

Renal Function Impairment

The t ½ is increased. Adjust dose.

Indications and Usage

Treatment of infections of urinary tract, skin and skin structures; treatment of pharyngitis and tonsillitis caused by susceptible strains of specific microorganisms.

Contraindications

Hypersensitivity to cephalosporins.

Dosage and Administration

Adults

PO 1 to 2 g/day in single dose or 2 divided doses.

Children

PO 30 mg/kg/day in single dose or 2 divided doses.

General Advice

Administer with food or milk if GI upset occurs.

Storage/Stability

Oral suspension must be refrigerated and will remain stable for up to 14 days. Do not freeze. Shake well before use.

Drug Interactions

Probenecid

Inhibition of renal excretion of cefadroxil.

Laboratory Test Interactions

May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets but not with enzyme-based tests (eg, Clinistix , Tes-tape ); false-positive test results for proteinuria with acid and denaturization-precipitation tests; false-positive direct Coombs test results in certain patients (eg, those with azotemia); false elevations in urinary 17-ketosteroid values.

Adverse Reactions

GI

Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis.

Genitourinary

Pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy.

Hematologic

Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage.

Hepatic

Hepatic dysfunction, abnormal LFT results.

Miscellaneous

Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis; serum sickness–like reactions (eg, skin rash, polyarthritis, arthralgia, fever); candidal overgrowth.

Precautions

Monitor

Response to therapy

Monitor patient's response to therapy. Notify health care provider if infection does not improve or appears to worsen.

Side effects

Monitor patient for GI, DERM, and general body side effects, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping.


Pregnancy

Category B .

Lactation

Excreted in breast milk.

Children

In infants, consider benefits relative to risks. Drug may accumulate in newborns.

Hypersensitivity

Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-reactivity.

Renal Function

Use drug with caution in patients with renal function impairment. Dosage adjustment based on renal function may be required.

Superinfection

May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Pseudomembranous colitis

Consider in patients in whom diarrhea develops.

Overdosage

Symptoms

Seizures.

Patient Information

  • Instruct patient to complete full course of therapy.
  • Instruct patient to check body temperature daily. If fever persists more than a few days or if high fever (above 102°F) or shaking chills are noted, notify health care provider immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Advise diabetic patient to use enzyme-based tests (eg, Clinistix , Testape ) for monitoring urine glucose because drug may give false results with other tests.
  • Instruct patient to report these symptoms to health care provider: nausea, vomiting, diarrhea, skin rash, hives, muscle or joint pain.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home. Instruct patient to seek emergency care immediately if wheezing or difficulty in breathing occurs.

Recent Drug Updates at DrugIndexOnline:





Aloxi Aloxi
Generic Name: palonosetron (pa low NO seh tron) Brand Names: Aloxi What is palonosetron? Palonosetron blocks the actions of chemicals in the body that may cause nausea and vomiting. Palonosetron is used to prevent nausea and vomiting associated with cancer chemotherapy. Palonosetron may more...

Combivent Inhalation-Local Combivent Inhalation-Local
Some commonly used brand names are: In the U.S.— Combivent DuoNeb Another commonly used name for albuterol is salbutamol . Category Bronchodilator Description Ipratropium (i-pra-TROE-pee-um) and albuterol (al-BYOO-ter-ol) combination is a bronchodilator (medicine that opens up na more...

Cruex Antifungal Spray Powder Topical Cruex Antifungal Spray Powder Topical
Some commonly used brand names are: In the U.S.— Caldesene Medicated Powder Cruex Antifungal Cream Cruex Antifungal Powder Cruex Antifungal Spray Powder Decylenes Powder Desenex Antifungal Cream Desenex Antifungal Liquid Desenex Antifungal Ointment Desenex Antifungal Penetrating Foam Dese more...

Diovol Plus AF Diovol Plus AF
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...

Equanil Equanil
Some commonly used brand names are: In the U.S.— Equanil Meprospan 200 Meprospan 400 Miltown-200 Miltown-400 Miltown-600 Probate Trancot In Canada— Apo-Meprobamate Equanil Meprospan-400 Miltown Generic name product may be available in the U.S. Category Antianxiety agent D more...

Fluvoxamine Fluvoxamine
Generic Name: Fluvoxamine (floo-VOX-a-meen) Brand Name: Generic only. No brands available. Antidepressants may increase the risk of suicidal thoughts or actions in children and teenagers. The risk may be greater during the first few months that patients take Fluvoxamine . Be sure that the benefit more...

Nystatin Powder Nystatin Powder
Generic Name: Nystatin Topical Powder (nye-STAT-in) Brand Name: NystopNystatin Powder is used for:Treating certain fungal infections. It may also be used for other conditions as determined by your doctor. Nystatin Powder is an antifungal. It works by killing sensitive fungi. Do NOT use Nystatin more...

Ontak Ontak
Some commonly used brand names are: In the U.S.— Ontak Generic name product may be available in the U.S. † Not commercially available in Canada. Category Antineoplastic Description Denileukin diftitox (DEN-i-loo-kin DIF-ti-toks) is used to treat cutaneous T-cell lymphoma, more...