22 . October , 2018 - Monday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Ceftazidime

Big Image Pronouncation: (seff-TAZE-ih-deem)
Class: Antibiotic, Cephalosporin

Trade Names:
- Powder for Injection 1 g (as pentahydrate w/L-arginine)
- Powder for Injection 2 g (as pentahydrate w/L-arginine)

Trade Names:
- Powder for Injection 500 mg (2.3 mEq sodium/g)
- Powder for Injection 1 g (2.3 mEq sodium/g)
- Powder for Injection 2 g (2.3 mEq sodium/g)
- Powder for Injection 6 g (2.3 mEq sodium/g)
- Injection 1 g with 2.2 g dextrose hydrous
- Injection 2 g with 1.6 g dextrose hydrous

Trade Names:
- Powder for Injection 1 g (2.3 mEq sodium/g)
- Powder for Injection 2 g (2.3 mEq sodium/g)
- Powder for Injection 6 g (2.3 mEq sodium/g)
- Injection 1 g
- Injection 2 g

Trade Names:
- Powder for Injection 500 mg (as pentahydrate w/L-arginine)
- Powder for Injection 1 g (as pentahydrate w/L-arginine)
- Powder for Injection 2 g (as pentahydrate w/L-arginine)
- Powder for Injection 6 g (as pentahydrate w/L-arginine)

Mechanism of Action


Inhibits mucopeptide synthesis in bacterial cell wall.




C max is 45 to 90 mcg/mL (500 mg and 1 g doses).


C max is 17 to 39 mcg/mL (500 mg and 1 g doses). T max is about 1 h.


Ceftazidime is less than 10% protein bound. It is excreted in human milk in low concentrations.


The t ½ is about 1.9 to 2 h. About 80% to 90% is excreted unchanged by the kidneys. Renal Cl is about 100 mL/min. Plasma Cl is about 115 mL/min.

Special Populations

Renal Function Impairment

The t ½ is significantly prolonged. Dosage adjustments are recommended.

Indications and Usage

Treatment of infections of lower respiratory tract, skin and skin structures, urinary tract, bone and joint; treatment of gynecological infections; treatment of intra-abdominal infections; treatment of septicemia and CNS infections including meningitis caused by susceptible strains of specific microorganisms; concomitant antibiotic therapy.


Hypersensitivity to cephalosporins.

Dosage and Administration


IV/IM 250 mg to 2 g every 8 to 12 h.

Children 1 mo to 12 yr of age

IV 30 to 50 mg/kg every 8 h (max, 6 g/day).

Newborns younger than 4 wk of age

IV 30 mg/kg every 12 h.

General Advice

  • Follow manufacturer's instructions for reconstitution and dilution.
  • Reconstituted solution should be light yellow to amber; darkened solution or powder does not indicate altered potency. Do not administer if solution is cloudy or precipitate is present.
  • When giving by IM route, add 3 mL diluent to 1 g vial to yield 280 mg/mL. Inject deeply into large muscle (eg, upper outer quadrant of gluteus muscle or lateral thigh); massage well.
  • When giving by IV route, add 10 mL sterile water for injection to 1 g vial to yield 280 mg/mL. Administer slowly over 3 to 5 min.
  • For intermittent infusions, reconstituted solution can be further diluted with 50 to 100 mL of D5W or sodium chloride 0.9% and infused over 30 min.


Store sterile powder at room temperature and protect from light. When reconstituted with sterile water for injection, solution is stable for 7 days if refrigerated and for 18 to 24 h when stored at room temperature. If frozen immediately after reconstitution, solution is stable for 3 mo. Completely thaw frozen preparation at room temperature before use. After thawing, solution may be stored for 18 to 24 h at room temperature or 4 days in refrigerator. Do not refreeze.

Drug Interactions


Increased risk of nephrotoxicity.



Do not add aminoglycosides to ceftazidime solutions because inactivation of both drugs may result; administer at separate sites if concurrent therapy is indicated.

Sodium bicarbonate

Do not dilute ceftazidime with sodium bicarbonate.

Laboratory Test Interactions

May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets but not with enzyme-based tests (eg, Clinistix , Tes-Tape ); false-positive test results for proteinuria with acid and denaturization-precipitation tests; false-positive direct Coombs test result in certain patients (eg, those with azotemia); false elevations in urinary 17-ketosteroid values.

Adverse Reactions


Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis.


Pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy.


Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; thrombocytosis; decreased platelet function; anemia; aplastic anemia; hemorrhage.


Hepatic function impairment; cholestatic jaundice; abnormal LFT results.


Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis, arthralgia, fever); phlebitis; thrombophlebitis, and pain at injection site.



Response to therapy

Monitor patient's response to therapy. Notify health care provider if infection does not appear to improve or worsens.

Adverse reactions

Monitor patient for GI, DERM, and general body adverse reactions, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping.


Category B .


Excreted in breast milk.


Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-reactivity.

Renal Function

Use drug with caution in patients with renal function impairment. Dosage adjustment based on renal function may be required.


May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Pseudomembranous colitis

Consider in patients in whom diarrhea develops.



Neuromuscular excitability, asterixis, seizures, encephalopathy.

Patient Information

  • Remind patient to check body temperature daily. If fever persists for more than a few days or if high fever (higher than 102°F) or shaking chills are noted, notify health care provider immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Remind diabetic patient to use enzyme-based tests (eg, Clinistix , Tes-Tape ) for monitoring urine glucose because drug may give false results with other tests.
  • Advise patient to report these symptoms to health care provider: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
  • Instruct patient to seek emergency care immediately if wheezing or difficulty breathing occurs.
  • Advise patient not to drink alcoholic beverages or to take alcohol-containing medications while taking this medication and for several days after discontinuing it.

Recent Drug Updates at DrugIndexOnline:

Apo-Oxazepam Apo-Oxazepam
Some commonly used brand names are: In the U.S.— Alprazolam Intensol 1 Ativan 12 Dalmane 9 Diastat 7 Diazepam Intensol 7 Dizac 7 Doral 16 Halcion 18 Klonopin 5 Librium 3 Lorazepam Intensol 12 Niravam 1 Paxipam 10 ProSom 8 Restoril 17 Serax 14 Tranxene-SD 6 Tranxene-SD Half Strength 6 Tran more...

Aventyl HCl Aventyl HCl
Generic Name: nortriptyline (nor TRIP ti leen) Brand Names: Aventyl HCl, Pamelor What is Aventyl HCl (nortriptyline)? Nortriptyline is in a group of drugs called tricyclic antidepressants. Nortriptyline affects chemicals in the brain that may become unbalanced. Nortriptyline is used to more...

Bosentan Bosentan
Generic Name: Bosentan (boe-SEN-tan) Brand Name: Tracleer Bosentan may cause serious liver problems. Liver function tests should be done before and during treatment with Bosentan to monitor for side effects. Be sure to keep all doctor and lab appointments. You should usually not take Bosentan more...

Lithium Controlled-Release and Extended-Release Tablets Lithium Controlled-Release and Extended-Release Tablets
Generic Name: Lithium Controlled-Release and Extended-Release Tablets (LITH-ee-um) Brand Name: Examples include Eskalith CR and LithobidSymptoms of toxicity may sometimes occur even with normal doses of Lithium Controlled-Release and Extended-Release Tablets. Do not exceed the recommended dose. more...

Minoxidil Topical Minoxidil Topical
Some commonly used brand names are: In the U.S.— Rogaine Extra Strength For Men Rogaine For Men Rogaine For Women In Canada— Apo-Gain Gen-Minoxidil Minoxigaine Rogaine Generic name product may be available in the U.S. Category Hair growth stimulant, alopecia androgenetica, to more...

Nu-Pen-VK Nu-Pen-VK
Some commonly used brand names are: In the U.S.— Amoxil 1 Bactocill 11 Beepen-VK 13 Betapen-VK 13 Bicillin L-A 12 Cloxapen 5 Crysticillin 300 A.S. 12 Dynapen 6 Dycill 6 Geocillin 4 Geopen 4 Ledercillin VK 13 Mezlin 9 Nafcil 10 Nallpen 10 Omnipen 2 Omnipen-N 2 Pathocil 6 Pentids 12 Pen Vee more...

Praziquantel Praziquantel
Pronouncation: (pray-zih-KWAHN-tuhl) Class: Antihelminthic Trade Names: Biltricide - Tablets 600 mg Mechanism of Action Pharmacology Increases cell membrane permeability in susceptible worms, resulting in loss of intracellular calcium, massive contractions, and paralysis of their musculature. Phago more...

Promethazine injection Promethazine injection
Generic Name: promethazine hydrochloride Dosage Form: Injection, usp Rx only Promethazine Injection Description Promethazine HCl Injection, is a sterile, pyrogen-free solution for deep intramuscular or intravenous administration. Promethazine HCl (10H-Phenothiazine-10-ethanamine, N,N,α-tr more...