19 . September , 2018 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Ceftibuten

Big Image Pronouncation: (seff-TIE-byoo-ten)
Class: Antibiotic, Cephalosporin

Trade Names:
Cedax
- Capsules 400 mg
- Powder for oral suspension 90 mg per 5 mL
- Powder for oral suspension 180 mg per 5 mL

Mechanism of Action

Pharmacology

Inhibits mucopeptide synthesis in bacterial cell wall.

Pharmacokinetics

Absorption

Capsules

C max is 17.9 mcg/mL.

Suspension

C max is about 15 mcg/mL. T max is about 2.6 h. AUC is about 73.7 mcg•h/mL.

Food Capsules

T max is increased 1.75 h. C max is decreased 18%. AUC is decreased 8%.

Suspension

C max is decreased 17% to 26%. AUC is decreased 12% to 17%. Take on an empty stomach.

Distribution

Vd is about 0.21 L/kg (capsules) and 0.5 L/kg (suspension).

Elimination

The t ½ is about 2.4 h. Cl is about 1.3 mL/min/kg. About 56% is excreted in the urine and 39% in the feces.

Special Populations

Renal Function Impairment

The t ½ is increased and Cl decreased. Dosage adjustment is recommended.

Elderly

Drug accumulation in the plasma was increased to 40%. Dosage adjustment may be needed.

Indications and Usage

Treatment of pharyngitis/tonsillitis caused by Streptococcus pyogenes , otitis media caused by Moraxella catarrhalis , Haemophilus influenzae (including betalactamase-producing strains) or S. pyogenes , and acute bacterial exacerbation of chronic bronchitis caused by Streptococcus pneumoniae (penicillin-susceptible strains), H. influenzae (including betalactamase-producing strains) or M. catarrhalis (including betalactamase-producing strains).

Contraindications

Hypersensitivity to cephalosporins.

Dosage and Administration

Adults and Children 12 yr of age and older

PO 400 mg every day for 10 days.

Children younger than 12 yr of age

PO 9 mg/kg every day (max 400 mg) for 10 days. Give suspension 2 h before or 1 h after a meal.

General Advice

Administer oral suspension 2 h before or 1 h after meal.

Storage/Stability

After mixing, the suspension may be kept for 14 days stored in refrigerator. Keep tightly closed. Shake well before use. Capsules may be stored at room temperature.

Drug Interactions

None well documented.

Laboratory Test Interactions

May cause false-positive urine glucose test results with Benedict solution, Fehling solution or Clinitest tablets, but not with enzyme-based tests (eg, Clinistix , Test-tape ); false-positive test results for proteinuria with acid and denaturization-precipitation tests; false-positive direct Coombs test results in certain patients (eg, those with azotemia); false elevations in urinary 17-ketosteroid values.

Adverse Reactions

GI

Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis.

Genitourinary

Pyuria; dysuria; renal function impairment; reversible interstitial nephritis; hematuria; toxic nephropathy.

Hematologic

Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage.

Hepatic

Hepatic function impairment; abnormal LFT results.

Miscellaneous

Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis; serum sickness–like reactions (eg, skin rash, polyarthritis, arthralgia, fever); candidal overgrowth.

Precautions

Monitor

Response to therapy

Monitor patient's response to therapy. Notify health care provider if infection does not appear to improve or worsens.

Adverse reactions

Monitor patient for GI, DERM, and general body adverse reactions, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping.


Pregnancy

Category B .

Lactation

Undetermined.

Children

In infants, consider benefits relative to risks. Safety and efficacy in children younger than 6 mo of age not established.

Hypersensitivity

Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-sensitivity.

Renal Function

Use drug with caution in patients with renal function impairment. Dosage adjustment based on renal function may be required.

Superinfection

May result in bacterial or fungal overgrowth on nonsusceptible microorganisms.

Pseudomembranous colitis

Consider possibility in patients in whom diarrhea develops.

Hemodialysis patients

A single 400 mg capsule or 9 mg/kg (max, 400 mg) dose may be administered at the end of each hemodialysis session.

Overdosage

Symptoms

Seizures.

Patient Information

  • Inform diabetic patients that oral suspension contains 1 g sucrose/teaspoon of suspension.
  • Instruct patient to complete full course of therapy.
  • Have patient take drug with food or milk to avoid GI upset.
  • Notify health care provider if patient has penicillin allergy or cephalosporin allergy.
  • Notify health care provider of nausea, vomiting, or diarrhea, especially if severe or contains blood, mucus or pus.
  • Remind diabetic patient to use an enzyme-based test for urine glucose or may otherwise obtain a false-positive result.
  • Remind patient to check body temperature daily. If fever persists for more than a few days or if high fever (higher than 102°F) or shaking chills are noted, notify health care provider.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Instruct patient to seek emergency care if he or she experiences wheezing or difficulty breathing.

Recent Drug Updates at DrugIndexOnline:





efavirenz, emtricitabine, and tenofovir efavirenz, emtricitabine, and tenofovir
Generic Name: efavirenz, emtricitabine, and tenofovir (ef uh VY renz em tri SYT uh been ten O fo veer) Brand Names: Atripla What is efavirenz, emtricitabine, and tenofovir? Efavirenz, emtricitabine, and tenofovir is an antiviral medication that prevents human immunodeficiency virus ( more...

Elspar Elspar
Generic Name: asparaginase (a SPARE a ji nase) Brand Names: Elspar What is Elspar (asparaginase)? Asparaginase is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Asparaginase is used to treat acute lymphocytic lymphoma. more...

Femhrt Femhrt
Generic Name: Norethindrone/Ethinyl Estradiol (HRT) (nor-eth-IN-drone/ETH-in-il ess-tra-DYE-ole) Brand Name: FemhrtDo not use Femhrt to prevent heart disease, heart attacks, strokes, or dementia. Femhrt may increase the risk of heart disease (including heart attack), stroke, dementia, serious more...

FIRST-Progesterone VGS 50 FIRST-Progesterone VGS 50
Generic Name: progesterone vaginal (proe JESS te rone VAJ in ul) Brand Names: Crinone, Endometrin, FIRST-Progesterone VGS 200, FIRST-Progesterone VGS 400, Prochieve What is FIRST-Progesterone VGS 50 (progesterone vaginal)? Progesterone is a female hormone important for the regulation of more...

Licorice Licorice
Generic Name: Licorice (Glycyrrhiza glabra) (Not applicable.) Brand Name: Generics only. No brands available.Licorice is used for:Gastric and duodenal ulcers, bronchitis, coughs, arthritis, and hepatitis. It may have other uses as well. Check with your pharmacist for more details regarding the p more...

Loratadine Loratadine
Pronouncation: (lore-AT-uh-DEEN) Class: Piperidine, peripherally selective Trade Names: Alavert - Tablets, orally disintegrating 10 mg Trade Names: Children's Loratadine - Syrup 5 mg per 5 mL Trade Names: Claritin - Tablets 10 mg - Syrup 1 mg/mL Trade Names: Claritin Hives Relief - Tablets 10 mg Tr more...

penicillamine penicillamine
Generic Name: penicillamine (pen ih SILL ah meen) Brand Names: Cuprimine, Depen What is penicillamine? Penicillamine is a chelating agent. It attaches to other chemicals in the body, which aids in their removal. Penicillamine is used to remove excess copper associated with Wilson's disea more...

Pentrax Anti-Dandruff Tar Shampoo Topical Pentrax Anti-Dandruff Tar Shampoo Topical
Some commonly used brand names are: In the U.S.— Alphosyl Aquatar Balnetar Therapeutic Tar Bath Cutar Water Dispersible Emollient Tar Denorex Extra Strength Medicated Shampoo Denorex Extra Strength Medicated Shampoo with Conditioners Denorex Medicated Shampoo Denorex Medicated Shampoo and more...