22 . February , 2018 - Thursday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Cetirizine Hydrochloride/Pseudoephedrine Hydrochloride

Big Image Pronouncation: (se-TIR-i-zeen HYE-droe-KLOR-ide/SOO-doe-e-FED-rin HYE-droe-KLOR-ide)
Class: Upper respiratory combinations

Trade Names:
Zyrtec-D 12 Hour
- Tablets, extended-release cetirizine hydrochloride 5 mg/pseudoephedrine hydrochloride 120 mg

Indications and Usage

Relief of nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis.

Contraindications

Narrow-angle glaucoma; urinary retention; severe hypertension; severe coronary artery disease; patients receiving MAOIs or within 14 days of stopping such treatment; hypersensitivity to any component of the product, adrenergic agents, or other drugs of similar chemical structure; manifestations of patient idiosyncrasy to adrenergic agents, including arrhythmias, dizziness, insomnia, tremor, or weakness.

Dosage and Administration

Adults and children 12 yr of age and older

PO One 12-h tablet (cetirizine 5 mg/pseudoephedrine 120 mg) twice daily.

Hepatic or Renal Function Impairment
Adults and children 12 yr of age and older

PO One 12-h tablet (cetirizine 5 mg/pseudoephedrine 120 mg) once daily in patients on hemodialysis (Ccr less than 7 mL/min), with hepatic function impairment, or with decreased renal function (Ccr 11 to 31 mL/min).

General Advice

  • May be taken with or without food.
  • Patients must swallow extended-release tablet whole and not break or chew.

Storage/Stability

Store at 68° to 77°F.

Drug Interactions

Antihypertensive agents that interfere with sympathetic activity (eg, mecamylamine, methyldopa, reserpine)

Antihypertensive effects of these agents may be reduced.

Digitalis

Increased ectopic pacemaker activity.

MAOIs (eg, phenelzine)

Coadministration is contraindicated with pseudoephedrine and for 14 days after stopping the MAOI.

Sympathomimetic amines

Additive or potentiated effects on the CV system.

Laboratory Test Interactions

Positive reactions to skin tests may be prevented or diminished.

Adverse Reactions

CNS

Insomnia (4%); fatigue, somnolence (2%); dizziness (1%).

EENT

Pharyngitis (2%); epistaxis (1%).

GI

Dry mouth (4%).

Respiratory

Sinusitis (1%).

Miscellaneous

Accidental injury (1%).

Precautions

Pregnancy

Category C .

Lactation

Both ingredients are excreted in breast milk.

Children

Safety and efficacy not established in children younger than 12 yr of age.

Elderly

Use with caution, usually starting at the low end of the dosage range, because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.

Special Risk Patients

Use with caution in patients with diabetes mellitus, hypertension, hyperthyroidism, increased IOP, ischemic heart disease, prostatic hypertrophy, or renal function impairment.

Cognitive and motor impairment

Caution patients about operating potentially hazardous machinery (eg, driving) until they know whether the drug impairs their ability. Avoid use of alcohol.

Overdosage

Symptoms

Cetirizine

Drowsiness, irritability, somnolence.

Pseudoephedrine

Anxiety, cardiac arrhythmias, circulatory collapse, coma, convulsions, difficulty in micturition, giddiness, headache, insomnia, muscular weakness, nausea, palpitations, precordial pain, respiratory failure, restlessness, sweating, tachycardia, tenseness, thirst, toxic psychosis with delusions and hallucinations, vomiting.

Patient Information

  • Instruct patient regarding how to store, administer, and dispose of outdated medication.

Recent Drug Updates at DrugIndexOnline:





DOBUTaminein DOBUTaminein
Generic Name: dobutamine hydrochloride and dextrose monohydrate Dosage Form: Injection, usp Flexible Plastic Container Rx only DOBUTaminein Description Dobutamine in 5% Dextrose Injection, USP is a sterile, nonpyrogenic, prediluted solution of dobutamine hydrochloride and dextrose in water for more...

Garamycin Garamycin
Some commonly used brand names are: In the U.S.— Amikin 1 Garamycin 2 G-Mycin 2 Jenamicin 2 Kantrex 3 Nebcin 7 Netromycin 5 In Canada— Amikin 1 Garamycin 2 Nebcin 7 Netromycin 5 Note: For quick reference, the following aminoglycosides are numbered to match the corresponding more...

Glycopyrrolate injection Glycopyrrolate injection
Dosage Form: Injection For Intramuscular or Intravenous Administration Rx Only NOT FOR USE IN NEONATESCONTAINS BENZYL ALCOHOL DESCRIPTION: Glycopyrrolate Injection, USP is a clear, colorless, sterile solution of Glycopyrrolate, USP with Benzyl Alcohol, NF in Water for Injection, USP. The formula more...

Guiatuss DAC Guiatuss DAC
Generic Name: codeine, guaifenesin, and pseudoephedrine (KOE deen, gwye FEN e sin, and soo doe e FED rin) Brand Names: Biotussin DAC, Codafed, Codahistine Expectorant, Guiatuss DAC, Novahistine Expectorant, Nuco-Tuss Expectorant, Nucochem Expectorant What is Guiatuss DAC (codeine, guaife more...

Imdur Imdur
Generic name: Isosorbide mononitrate Brand names: Ismo, Monoket, Imdur Why is Imdur prescribed? Imdur is prescribed to prevent angina pectoris (crushing chest pain that results when partially clogged arteries restrict the flow of needed oxygen-rich blood to the heart muscle). This medication doe more...

Levobunolol Drops Levobunolol Drops
Generic Name: Levobunolol Eye Drops (lee-voe-BYOO-noe-lole) Brand Name: BetaganLevobunolol Drops is used for:Lowering eye pressure and treating glaucoma. It may also be used for other conditions as determined by your doctor. Levobunolol Drops is an ophthalmic beta-blocker. It is unknown exactly more...

metronidazole topical metronidazole topical
Generic Name: metronidazole topical (me troe NI da zole) Brand Names: Metrocream, Metrogel, Metrolotion, Noritate What is metronidazole topical? Metronidazole is an antibiotic. Metronidazole topical prevents bacteria from growing on your skin. Metronidazole topical is used topically to t more...

Oxandrin Oxandrin
Some commonly used brand names are: In the U.S.— Anadrol-50 3 Deca-Durabolin 1 Durabolin 1 Durabolin-50 1 Hybolin Decanoate 1 Hybolin-Improved 1 Kabolin 1 Oxandrin 2 Winstrol 4 In Canada— Anapolon 50 3 Deca-Durabolin 1 Note: For quick reference, the following anabolic steroi more...