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All about: Chlordiazepoxide hydrochloride, Clidinium bromide

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Generic name: Chlordiazepoxide hydrochloride, Clidinium bromide
Brand names: Librax

Why is Chlordiazepoxide hydrochloride, Clidinium bromide prescribed?

Librax is used, in combination with other therapy, for the treatment of peptic ulcer, irritable bowel syndrome (spastic colon), and acute enterocolitis (inflammation of the colon and small intestine). Librax is a combination of a benzodiazepine (chlordiazepoxide) and an antispasmodic medication (clidinium).

Most important fact about Chlordiazepoxide hydrochloride, Clidinium bromide

Because of its sedative effects, you should not operate heavy machinery, drive, or engage in other hazardous tasks that require you to be mentally alert while you are taking Librax.

How should you take Chlordiazepoxide hydrochloride, Clidinium bromide?

Take Librax as directed by your doctor. Other therapy may be prescribed to be used at the same time.

Librax can make your mouth dry. For temporary relief, suck a hard candy or chew gum.

Take Librax before meals and at bedtime.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store away from heat, light, and moisture.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Librax.

  • Side effects may include:
    Blurred vision, changes in sex drive, confusion, constipation, drowsiness, dry mouth, fainting, lack of coordination, liver problems, minor menstrual irregularities, nausea, skin eruptions, swelling due to fluid retention, urinary difficulties, yellowing of skin and eyes

Why should Chlordiazepoxide hydrochloride, Clidinium bromide not be prescribed?

You should not take Chlordiazepoxide hydrochloride, Clidinium bromide if you have glaucoma (elevated pressure in the eye), prostatic hypertrophy (enlarged prostate), or a bladder obstruction. If you are sensitive to or have ever had an allergic reaction to Librax or any of its ingredients, you should not take Chlordiazepoxide hydrochloride, Clidinium bromide. Make sure your doctor is aware of any drug reactions you have experienced.

Special warnings about Chlordiazepoxide hydrochloride, Clidinium bromide

Librax can be habit-forming and has been associated with drug dependence and addiction. Be very careful taking Chlordiazepoxide hydrochloride, Clidinium bromide if you have ever had problems with alcohol or drug abuse. Never take more than the prescribed amount.

In addition, you should not stop taking Librax suddenly, because of the risk of withdrawal symptoms (convulsions, cramps, tremors, vomiting, sweating, feeling depressed, and insomnia). If you have been taking Librax over a long period of time, your doctor will have you taper off gradually.

The elderly are more likely to develop side effects such as confusion, excessive drowsiness, and uncoordinated movements when taking Librax. The doctor will probably prescribe a low dose.

Long-term treatment with Librax may call for periodic blood and liver function tests.

Possible food and drug interactions when taking Chlordiazepoxide hydrochloride, Clidinium bromide

If Librax is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important to check with your doctor before combining Librax with the following:

Antidepressant drugs known as MAO inhibitors, such as Nardil and Parnate
Blood-thinning drugs such as Coumadin
Certain diarrhea medications such as Donnagel and Kaopectate
Ketoconazole (Nizoral)
Major tranquilizers such as Stelazine and Thorazine
Potassium supplements such as Micro-K

In addition, you may experience excessive drowsiness and other potentially dangerous side effects if you combine Librax with alcohol or other drugs, such as Benadryl and Valium, that make you drowsy.

Special information if you are pregnant or breastfeeding

Several studies have found an increased risk of birth defects if Librax is taken during the first 3 months of pregnancy. Therefore, Librax is rarely recommended for use by pregnant women. If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor immediately.

Recommended dosage

ADULTS

The usual dose is 1 or 2 capsules, 3 or 4 times a day before meals and at bedtime.

OLDER ADULTS

Your doctor will have you take the lowest dose that is effective.

Overdosage

Any medication taken in excess can have serious consequences. A severe overdose of Librax can be fatal. If you suspect an overdose, seek medical help immediately.

  • Symptoms of Librax overdose may include:
    Blurred vision, coma, confusion constipation excessive sleepiness, excessively dry mouth, slow reflexes, urinary difficulties

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