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All about: Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets

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Generic Name: Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets (klor-fen-IHR-ah-meen/fen-ill-EF-rin/peer-IL-a-meen)
Brand Name: Examples include Poly Hist Forte and Ru-Hist Forte

Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets is used for:

Relieving symptoms of sinus congestion, pressure, runny nose, and sneezing due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets is an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, which relieves congestion and pressure.

Do NOT use Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets if:

  • you are allergic to any ingredient in Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you take sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets:

Some medical conditions may interact with Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of asthma; lung problems (eg, emphysema); adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate; seizures; or an overactive thyroid

Some MEDICINES MAY INTERACT with Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, monoamine oxidase (MAO)inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets may be increased
  • Digoxin or droxidopa because risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets:

Use Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets may be taken with or without food.
  • Swallow Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing. Some brands of Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets may be broken in half before they are taken. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand may be broken in half.
  • If you miss a dose of Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets.

Important safety information:

  • Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets. Using Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take diet or appetite control medicines while you are taking Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets without checking with your doctor.
  • Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets contains phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.
  • Do NOT exceed the recommended dose or take Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets for longer than prescribed without checking with your doctor.
  • If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.
  • Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • If you are scheduled for allergy skin testing, do not take Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets for several days before the test because it may decrease your response to the skin tests.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets.
  • Use Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets with caution in the ELDERLY because they may be more sensitive to its effects.
  • Caution is advised when using Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets, discuss with your doctor the benefits and risks of using Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets during pregnancy. It is unknown if Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets is excreted in breast milk. Do not breast-feed while taking Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets.

Possible side effects of Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets:

Store Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Chlorpheniramine/Phenylephrine/Pyrilamine Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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