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All about: clomiphene

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Generic Name: clomiphene (KLOE mih feen)
Brand Names: Clomid, Serophene

What is clomiphene?

Clomiphene stimulates the release of hormones necessary for ovulation to occur.

Clomiphene is used to stimulate ovulation (the release of an egg) when a woman's ovaries can produce a follicle but hormonal stimulation is deficient.

Clomiphene may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about clomiphene?

Use caution when driving, operating machinery, or performing other hazardous activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after therapy. Notify your doctor immediately if you develop any visual side effects and use caution when performing hazardous activities, especially under conditions of variable lighting.

Clomiphene may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

Who should not take clomiphene?

Do not take clomiphene without first talking to your doctor if you
  • might be pregnant;

  • have a thyroid problem or another endocrine disorder;

  • have undiagnosed vaginal bleeding;

  • have endometriosis or endometrial carcinoma;

  • have uterine fibroids;

  • have liver disease;

  • have ovarian cysts or ovarian enlargement not due to polycystic ovarian syndrome; or

  • have any other serious or chronic medical illness.

You may not be able to take clomiphene, or you may require a lower dose or special monitoring if you have any of the conditions listed above.

Do not take clomiphene if you are pregnant. Clomiphene is in the FDA pregnancy category X. This means that it is known to cause birth defects. It is not known whether clomiphene pass into breast milk. Do not take clomiphene without first talking to your doctor if you are breast-feeding a baby.

How should I take clomiphene?

Use clomiphene exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Take each dose with a full glass of water.

Clomiphene is usually taken in 5 day cycles. Follow your doctor's instructions.

Store clomiphene at room temperature, away from direct light, moisture, and heat.

What happens if I miss a dose?

Contact your doctor if you miss a dose of clomiphene.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a clomiphene overdose include nausea, vomiting, flushing, blurred vision, visual spots or flashes, and abdominal pain.

What should I avoid while taking clomiphene?

Use caution when driving, operating machinery, or performing other hazardous activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after therapy. Notify your doctor immediately if you develop any visual side effects and use caution when performing hazardous activities, especially under conditions of variable lighting.

Clomiphene side effects

Stop taking clomiphene and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

The ovarian hyperstimulation syndrome (OHSS) has been reported to occur in patients receiving clomiphene. Symptoms of OHSS include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. OHSS can be fatal. Notify your doctor immediately or seek emergency medical attention if you develop any of these side effects.

Other side effects may also occur. Notify your doctor if you experience

  • ovarian enlargement presenting as abdominal or pelvic pain, tenderness, pressure, or swelling;

  • flushing;

  • nausea, vomiting, or diarrhea;

  • breast tenderness or discomfort;

  • blurred vision or other visual disturbances;

  • headache; or

  • abnormal uterine bleeding.

Clomiphene may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect clomiphene?

There are no known interactions between clomiphene and other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about clomiphene written for health professionals that you may read.

What does my medication look like?

Clomiphene is available with a prescription generically and under the brand names Clomid and Serophene. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Clomid 50 mg-round, white, scored tablets

  • Serophene 50 mg-white, scored tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.04. Revision Date: 2/13/04 4:00:38 PM.

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