14 . November , 2018 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Contraceptives, Oral (Progestin-Only Products)

Big Image Pronouncation: (kon-tra-SEP-tiv, OR-al)
Class: Hormone, Contraceptive

Trade Names:
- Tablets 0.35 mg norethindrone

Trade Names:
- Tablets 0.35 mg norethindrone

Trade Names:
- Tablets 0.075 mg norgestrel

Mechanism of Action


Alters cervical mucus, interferes with implantation, and may suppress ovulation.

Indications and Usage

Prevention of pregnancy.


Thrombophlebitis; thromboembolic disorders; history of deep vein thrombophlebitis; cerebral vascular disease; MI; coronary artery disease; known or suspected breast carcinoma; impaired liver function or disease; undiagnosed abnormal genital bleeding; known or suspected pregnancy; as diagnostic test for pregnancy.

Dosage and Administration


PO 1 tablet daily, starting on first day of menstruation.

General Advice

If GI upset occurs, administer with food.

Drug Interactions

Hydantoins (eg, phenytoin)

May reduce plasma levels and pharmacologic effect of levonorgestrel and norgestrel.


Reduced plasma levels and pharmacologic effects of norethindrone.

Laboratory Test Interactions

Results of LFTs, coagulation tests (increased prothrombin, factors VII, VIII, IX and X), thyroid function tests, metyrapone test, and endocrine function tests may be altered. Pregnanediol determination may be altered.

Adverse Reactions


Thrombophlebitis; cerebrovascular disorders.


Depression; tiredness; fatigue.


Rash with and without pruritus; acne; melasma or chloasma; photosensitivity.


Retinal thrombosis.


Breakthrough bleeding; spotting; hypomenorrhea; amenorrhea; changes in cervical erosion and cervical secretions.


Cholestatic jaundice.


Pulmonary embolism.


Breast changes; masculinization of female fetus; edema; weight change.



Category X.


Excreted in breast milk.

Tartrazine Sensitivity

Some products may contain tartrazine, which may cause allergic-type reaction in susceptible individuals.


Use drug with caution in patients with history of depression.

Fluid retention

Use with caution in patients with hypertension; convulsive disorders; migraines; asthma; cardiac, hepatic, or renal dysfunction.

Lipid disorders

Progestins may elevate LDL levels.




Patient Information

  • Advise patient to use additional method of birth control until after first wk of administration in initial cycle.
  • Teach patient what to do if dose is missed. If 1 tablet is missed, take as soon as remembered and then take next tablet at regular time. If 2 consecutive tablets are missed; do not take missed tablets; discard and take next tablet at regular time. Use additional form of contraception until pregnancy is ruled out or menses occurs. If 3 consecutive tablets are missed, discontinue drug immediately. Use additional form of contraception until pregnancy is ruled out or menses occurs.
  • Encourage patient who smokes to stop. Cardiovascular dysfunction and thromboembolic disease have been associated with use of oral contraceptives in patients who smoke.
  • Advise patient that oral contraceptives may change fit of rigid contact lenses.
  • Caution patient to avoid prolonged exposure to sunlight, and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
  • Advise patient to wait at least 3 mo after discontinuing oral contraceptives before trying to become pregnant.
  • Instruct patient to report symptoms of blood clots (eg, pain, numbness, shortness of breath, visual disturbances).

Recent Drug Updates at DrugIndexOnline:

Alphatrex Alphatrex
Generic Name: betamethasone topical (bay ta MEH tha sone) Brand Names: Alphatrex, Beta-Val, Betaderm, Betanate, Betatrex, Diprolene, Diprolene AF, Diprosone, Luxiq, Maxivate, Teladar, Uticort, Valisone What is Alphatrex (betamethasone topical)? Betamethasone is a topical steroid. It red more...

Depo-SubQ Provera 104 Depo-SubQ Provera 104
Generic Name: medroxyprogesterone acetate Dosage Form: Injectable suspension 104 mg/0.65 ml Physician Information Women who use Depo-SubQ Provera 104 may lose significant bone mineral density. Bone loss is greater with increasing duration of use and may not be completely reversible. It is unk more...

GyneCure Vaginal GyneCure Vaginal
Some commonly used brand names are: In the U.S.— FemCare 2 Femizol-M 4 Femstat 3 1 Gyne-Lotrimin 2 Gyne-Lotrimin Combination Pack 2 Gyne-Lotrimin3 2 Gyne-Lotrimin3 Combination Pack 2 Miconazole-7 4 Monistat 1 6 Monistat 1 Combination Pack 4 Monistat 3 4 Monistat 3 Combination Pack 4 Monis more...

Hydrochlorothiazide Solution Hydrochlorothiazide Solution
Generic Name: Hydrochlorothiazide Oral Solution (hye-droe-klor-oh-THYE-a-zide) Brand Name: Generic only. No brands available.Hydrochlorothiazide Solution is used for:Treating excess fluid buildup in the body caused by certain conditions or medicines. It may also be used to treat high blood pressu more...

Lasix Lasix
Generic Name: furosemide Dosage Form: Tablets Warning Lasix® (furosemide) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose and dose schedule must be adj more...

Levulan Kerastick Topical Levulan Kerastick Topical
Some commonly used brand names are: In the U.S.— Levulan Kerastick Category Photosensitizer Photodynamic therapy Description Aminolevulinic acid ((a-mee-noh-LEV-U-lin-ik AS-id)) application followed by exposure to a certain type of light (blue light using the BLU-U Blue Light Pho more...

NP-27 Powder Topical NP-27 Powder Topical
Some commonly used brand names are: In the U.S.— Aftate for Athlete's Foot Aerosol Spray Liquid Aftate for Athlete's Foot Aerosol Spray Powder Aftate for Athlete's Foot Gel Aftate for Athlete's Foot Sprinkle Powder Aftate for Jock Itch Aerosol Spray Powder Aftate for Jock Itch Gel Aftate more...

OFF! Skintastic For Kids Topical OFF! Skintastic For Kids Topical
Some commonly used brand names are: In the U.S.— Backwoods Cutter Cutter Pleasant Protection Deep Woods OFF! Deep Woods OFF! For Sportsmen Muskol OFF! OFF! For Maximum Protection OFF! Skintastic OFF! Skintastic For Children OFF! Skintastic For Kids Ultra Muskol In Canada— Deep Woo more...