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All about: Crestor

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Generic Name: Rosuvastatin (roe-SOO-va-STAT-in)
Brand Name: Crestor

Crestor is used for:

Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used along with an appropriate diet. It may also be used for other conditions as determined by your doctor.

Crestor is an HMG-CoA reductase inhibitor, also known as a "statin." It works by reducing the production of certain fatty substances in the body, including cholesterol.

Do NOT use Crestor if:

  • you are allergic to any ingredient in Crestor
  • you have liver problems or unexplained abnormal liver function tests
  • you are pregnant or breast-feeding
  • you are taking itraconazole, mibefradil, or telithromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Crestor :

Some medical conditions may interact with Crestor . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have low blood pressure, a serious infection, kidney problems, an underactive thyroid, diabetes, or a history of seizures
  • if you are dehydrated or have certain muscle problems (eg, pain, weakness); have increased creatine phosphokinase (CPK) blood levels; or have metabolism, hormonal, or electrolyte problems
  • if you are on dialysis
  • if you drink alcohol or have a history of liver problems or alcohol abuse
  • if you have had an organ transplant or have recently had major surgery or a serious injury

Some MEDICINES MAY INTERACT with Crestor . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fibrates (eg, gemfibrozil, clofibrate), immunosuppressants (eg, cyclosporine), lopinavir/ritonavir or niacin because they may increase the risk of muscle or kidney problems
  • Anticoagulants (eg, warfarin), cimetidine, ketoconazole, macrolide immunosuppressants (eg, tacrolimus), or spironolactone because the risk of their side effects may be increased by Crestor

This may not be a complete list of all interactions that may occur. Ask your health care provider if Crestor may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Crestor :

Use Crestor as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Crestor by mouth with or without food.
  • If you also take an antacid that has aluminum or magnesium in it, take it at least 2 hours after taking Crestor . Check with your doctor if you have any questions.
  • Continue to take Crestor even if you feel well. Do not miss any doses.
  • If you miss a dose of Crestor , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Crestor .

Important safety information:

  • Crestor may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Crestor with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Drinking alcohol daily or in large amounts may increase the risk of liver problems with Crestor . Check with your doctor before drinking alcohol while you are taking Crestor .
  • Follow the diet and exercise program given to you by your health care provider.
  • Tell your doctor or dentist that you take Crestor before you receive any medical or dental care, emergency care, or surgery.
  • Women who may become pregnant should use effective birth control while taking Crestor . Check with your doctor if you have questions about using birth control.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort.
  • Lab tests, including blood cholesterol levels, liver function, kidney function, and creatine phosphokinase (CPK) blood levels, may be performed while you use Crestor . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Crestor with caution in Asian patients and ELDERLY patients; they may be more sensitive to its effects, especially serious muscle problems (eg, muscle pain, tenderness, or weakness).
  • Crestor should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Crestor if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Crestor is found in breast milk. Do not breast-feed while taking Crestor .

Possible side effects of Crestor :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; sore throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; joint pain; muscle pain, tenderness, or weakness (with or without fever or fatigue); pale stools; severe or persistent headache; stomach pain; swelling of the hands, ankles, or feet; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Crestor :

Store Crestor at room temperature, between 68 and 77 degrees F (20 to 25 degrees C). Store away from heat, moisture, and light. Keep Crestor out of the reach of children and away from pets.

General information:

  • If you have any questions about Crestor , please talk with your doctor, pharmacist, or other health care provider.
  • Crestor is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Crestor . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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