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All about: Cyclizine

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Generic Name: Cyclizine (SYE-kli-zeen)
Brand Name: Marezine

Cyclizine is used for:

Preventing and treating nausea, vomiting, and dizziness associated with motion sickness. It may also be used for other conditions as determined by your doctor.

Cyclizine is an anticholinergic. It works by blocking a chemical messenger in the brain, which helps to reduce or prevent vomiting.

Do NOT use Cyclizine if:

  • you are allergic to any ingredient in Cyclizine
  • you are taking sodium oxybate (GHB) or anticholinergics (eg, scopolamine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cyclizine :

Some medical conditions may interact with Cyclizine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • you have asthma; chronic obstructive pulmonary disease (COPD); chronic bronchitis or emphysema; shortness of breath or difficulty breathing; a blockage of the stomach, intestine, or urinary tract; enlargement of the prostate; difficulty urinating; or glaucoma
  • if you have recently had surgery

Some MEDICINES MAY INTERACT with Cyclizine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur
  • Anticholinergics (eg, scopolamine) because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cyclizine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cyclizine :

Use Cyclizine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cyclizine may be taken with or without food.
  • For prevention of motion sickness, take Cyclizine at least 30 minutes before activity or travel.
  • Use Cyclizine exactly as directed on the package, unless instructed differently by your doctor. If you are taking Cyclizine without a prescription, follow any warnings and precautions on the label.
  • If you miss a dose of Cyclizine and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cyclizine .

Important safety information:

  • Cyclizine may cause drowsiness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Cyclizine . Using Cyclizine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Cyclizine . Cyclizine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Cyclizine .
  • Do not exceed the recommended dose or use Cyclizine longer than prescribed without checking with your doctor.
  • Cyclizine is not recommended for use in CHILDREN younger than 6 years of age without checking with your doctor. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Cyclizine during pregnancy. It is unknown if Cyclizine is excreted in breast milk. If you are or will be breast-feeding while you are using Cyclizine , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Cyclizine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include drowsiness; hallucinations; seizures; unusual excitability; very slow or shallow breathing.

Proper storage of Cyclizine :

Store Cyclizine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cyclizine out of the reach of children and away from pets.

General information:

  • If you have any questions about Cyclizine , please talk with your doctor, pharmacist, or other health care provider.
  • Cyclizine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Cyclizine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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