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All about: Alatrofloxacin

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Some commonly used brand names are:

In the U.S.—

  • Trovan
This information applies to the following medicines
1. Alatrofloxacin (a-lat-roe-FLOX-a-sin)
2. Trovafloxacin (TRO-va-flox-a-sin)

Category

  • Antibacterial (systemic)

Description

Alatrofloxacin and trovafloxacin are used to treat very serious bacterial infections in many different parts of the body. They work by killing bacteria or preventing their growth. However, these medicines will not work for colds, flu, or other virus infections.

Liver failure has been reported rarely with the use of alatrofloxacin and trovafloxacin. Because of the risk of liver problems, these medicines are used only to treat serious bacterial infections, such as those that are life-threatening or when there is a risk of losing a limb. Because of this, treatment usually is started in the hospital or in another in-patient health care facility.

These medicines are available only with your doctor's prescription, in the following dosage forms:

  • Oral
  • Trovafloxacin
    • Tablets (U.S.)
  • Parenteral
  • Alatrofloxacin
    • Injection (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For alatrofloxacin or trovafloxacin, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to alatrofloxacin, trovafloxacin, any of the fluoroquinolones, or any related medicines, such as cinoxacin (e.g., Cinobac) or nalidixic acid (e.g., NegGram). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Studies have not been done in humans. However, use is not recommended during pregnancy since alatrofloxacin and trovafloxacin have been reported to cause bone development problems in young animals.

Breast-feeding—Alatrofloxacin and trovafloxacin pass into breast milk. Since alatrofloxacin and trovafloxacin have been reported to cause bone development problems in young animals, breast-feeding is not recommended during treatment with either of these medicines.

Children—Use is not recommended for infants, children, or teenagers up to 18 years of age since alatrofloxacin and trovafloxacin have been shown to cause bone development problems in young animals.

Older adults—Alatrofloxacin and trovafloxacin have been tested in and, in effective doses, have not been shown to cause different side effects or problems in older people than they do in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking alatrofloxacin or trovafloxacin, it is especially important that your health care professional know if you are taking any of the following:

  • Antacids that contain aluminum or magnesium or
  • Citric acid buffered with sodium citrate (e.g., Bicitra) or
  • Iron supplements or other vitamins or
  • Morphine (injection dosage form) or
  • Sucralfate—Antacids, citric acid buffered with sodium citrate, iron or vitamins, intravenous morphine, or sucralfate may keep trovafloxacin tablets from working properly

Other medical problems—The presence of other medical problems may affect the use of alatrofloxacin or trovafloxacin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Brain or spinal cord disease, including hardening of the arteries in the brain, or epilepsy or other problems that may cause seizures—Alatrofloxacin or trovafloxacin may cause nervous system side effects
  • Liver disease—Patients with liver disease may have an increased chance of side effects

Proper Use of This Medicine

Do not take alatrofloxacin or trovafloxacin if you are pregnant. Do not give alatrofloxacin or trovafloxacin to infants, children, or teenagers unless otherwise specified by your doctor. These medicines have been shown to cause bone development problems in young animals.

Trovafloxacin tablets may be taken with or without meals.

If you are taking alatrofloxacin injection, use it exactly as directed by your doctor. If you have any questions, ask your health care professional.

To help clear up your infection completely, keep taking alatrofloxacin or trovafloxacin for the full time of treatment , even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

Alatrofloxacin and trovafloxacin work best when there is a constant amount in the blood or urine. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night . For example, if you are to take one dose a day, that dose should be taken about the same time every day. If this interferes with your sleep or other daily activities, or if you need help in planning the best time to take your medicine, check with your health care professional.

Dosing—The doses of alatrofloxacin or trovafloxacin will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. Your dose may be different if you have liver disease. If your dose is different, do not change it unless your doctor tells you to do so.

If you are taking trovafloxacin tablets, the number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking trovafloxacin . In general, the Food and Drug Administration (FDA) recommends that treatment with trovafloxacin not go beyond 14 days. Longer treatment may increase the chance of liver problems.

  • For oral dosage form (trovafloxacin tablets):
    • For treatment of bacterial infections:
      • Adults—100 or 200 milligrams (mg) once every twenty-four hours for three days to several weeks, depending on the medical problem being treated. Gonorrhea is treated with a single oral dose of 100 mg.
      • Children up to 18 years of age—This medicine is not recommended for infants, children, or teenagers.
    • For prevention of infection in surgical patients:
      • Adults—200 milligrams one-half to four hours before the start of surgery.
      • Children up to 18 years of age—This medicine is not recommended for infants, children, or teenagers.
  • For injection dosage form (alatrofloxacin injection):
    • For treatment of bacterial infections:
      • Adults—200 to 300 milligrams (mg) injected slowly into a vein over a period of sixty minutes, once every twenty-four hours for up to fourteen days, depending on the medical problem being treated.
      • Children up to 18 years of age—This medicine is not recommended for infants, children, or teenagers.
    • For prevention of infection in surgical patients:
      • Adults—200 milligrams injected slowly into a vein over a period of sixty minutes, one half to four hours before the start of surgery.
      • Children up to 18 years of age—This medicine is not recommended for infants, children, or teenagers.

Missed dose—If you are taking trovafloxacin tablets and you miss a dose of this medicine, take it as soon as possible if remembered the same day. This will help to keep a constant amount of medicine in the blood or urine. However, if you do miss a dose on one day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Alatrofloxacin and trovafloxacin may cause liver problems, including liver failure, at any time during treatment in a small number of people who are treated with these medicines. Check with your doctor immediately if you notice that your urine has become dark or your skin or eyes are yellow in color or if you experience loss of appetite, nausea or vomiting, severe abdominal pain, or unusual tiredness or weakness. These may be possible signs or symptoms of a liver problem.

If you are taking aluminum- or magnesium-containing antacids, citric acid buffered with sodium citrate (e.g., Bicitra), iron supplements or vitamins, intravenous morphine, or sucralfate, do not take them at the same time that you take trovafloxacin tablets. It is best to take these medicines at least 2 hours before or 2 hours after taking trovafloxacin. These medicines may keep trovafloxacin tablets from working properly.

Some people who take alatrofloxacin or trovafloxacin may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn or skin rash, redness, itching, or discoloration. When you begin taking this medicine:

  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
  • Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor .

Alatrofloxacin or trovafloxacin may cause some people to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert . If these reactions are especially bothersome, check with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Abdominal or stomach cramps and pain (severe); abdominal tenderness; agitation; confusion; dark urine; diarrhea (watery and severe, which may also be bloody); difficulty in breathing or swallowing; fever; hallucinations (seeing, hearing, or feeling things that are not there); loss of appetite; nausea or vomiting; pain at place of injection; pain in calves that spreads to heels; rapid heartbeat; shakiness or tremors; shortness of breath; skin rash, itching, or redness; swelling of face, throat, or tongue; swelling of calves or lower legs; unusual tiredness or weakness; yellow eyes or skin

Note:

Some of the above side effects may also occur up to several weeks after you stop taking this medicine.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Diarrhea (mild); dizziness or lightheadedness; headache; vaginal pain and discharge

Less common or rare

Increased sensitivity of skin to sunlight

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 06/16/1999

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