14 . December , 2018 - Friday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Desloratadine

Big Image Pronouncation: (dess-lore-AT-ah-deen)
Class: Peripherally selective piperidine

Trade Names:
Clarinex
- Tablets 5 mg

Trade Names:
Clarinex RediTabs
- Tablets, rapidly disintegrating 5 mg

Aerius (Canada)

Mechanism of Action

Pharmacology

Long-acting histamine antagonist with selective H 1 -receptor histamine antagonist activity.

Pharmacokinetics

Absorption

T max approximately 3 h. C max approximately 4 ng/mL. AUC approximately 56.9 ng•h/mL.

Distribution

82% to 87% protein bound.

Metabolism

Metabolized to 3-hydroxydesloratadine (active).

Elimination

The t ½ is 27 h. Approximately 87% excreted in urine and feces.

Onset

1 h.

Duration

24 h.

Special Populations

Renal Function Impairment

AUC and C max are increased. Dosage adjustment is recommended.

Hepatic Function Impairment

AUC and t ½ are increased. Dosage adjustment is recommended.

Elderly

C max and AUC are 20% greater. The t ½ is 33.7 h.

Indications and Usage

Relief of nasal and nonnasal symptoms of seasonal and perennial allergic rhinitis; in chronic idiopathic urticaria for relief of symptoms of pruritus and reduction in number and size of hives.

Contraindications

Hypersensitivity to any components of the product or to loratadine.

Dosage and Administration

Adults and Children 12 yr of age and older

PO 5 mg once daily.

Renal/Hepatic impairment

PO 5 mg every other day.

Storage/Stability

Store tablets and orally disintegrating tablets at controlled room temperature (59° to 86°F). Do not remove orally disintegrating tablet from blister until just prior to administration.

Drug Interactions

None well documented.

Laboratory Test Interactions

May prevent or diminish otherwise positive reactions to skin tests.

Adverse Reactions

Cardiovascular

Tachycardia, palpitations (postmarketing).

CNS

Headache (14%); fatigue (5%); dizziness (4%); somnolence (2%).

EENT

Pharyngitis (4%); dry mouth (3%).

GI

Nausea (5%); dyspepsia (3%).

Genitourinary

Dysmenorrhea (2%).

Miscellaneous

Myalgia (3%); hypersensitivity (including rash, pruritus, urticaria, edema, dyspnea, anaphylaxis [postmarketing]).

Precautions

Monitor

Assess patient for allergy symptoms (eg, rhinitis, nasal congestion, sneezing, itching, watery eyes, hives) before starting therapy and periodically throughout therapy. Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy.


Pregnancy

Category C .

Lactation

Excreted in breast milk.

Children

Safety and efficacy not established in children younger than 12 yr of age.

Elderly

Select dose with caution, reflecting greater frequency of decreased hepatic, renal, or cardiac function and comorbidity.

Renal Function

Dosage adjustment is recommended.

Hepatic Function

Dosage adjustment is recommended.

Overdosage

Symptoms

Increased heart rate and corrected QT interval.

Patient Information

  • Advise patient to take dose daily as prescribed and not to stop taking or change the dose unless advised by health care provider.
  • Ensure patient understands how to store and take the orally disintegrating tablet.
  • Advise patient to take without regard to meals but to take with food if stomach upset occurs.
  • Advise patient that if allergy symptoms are not controlled, not to increase the dose of medication or frequency of use but to inform health care provider. Inform patient that larger or more frequent dosing does not increase effectiveness and may cause drowsiness.
  • Caution patient to avoid alcohol and other CNS depressants (eg, sedatives) while using this medication.
  • Caution patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
  • Advise patient to take frequent sips of water, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • If patient is to have allergy skin testing, advise not to take the medication for at least 4 days before the skin testing.
  • Instruct patient to stop taking drug and report persistent dizziness or excessive drowsiness to health care provider.

Recent Drug Updates at DrugIndexOnline:





Astracaine 4% Parenteral-Local Astracaine 4% Parenteral-Local
Some commonly used brand names are: In the U.S.— Carbocaine 7 Carbocaine with Neo-Cobefrin 7 Chirocaine 5 Citanest Forte 8 Citanest Plain 8 Dalcaine 6 Dilocaine 6 Duranest 4 Duranest-MPF 4 Isocaine 7 L-Caine 6 Lidoject-1 6 Lidoject-2 6 Marcaine 2 Marcaine Spinal 2 Nesacaine 3 Nesacaine-MP more...

Cipro Cipro
Generic name: Ciprofloxacin hydrochloride, Cipro- - ciprofloxacin hydrochloride Cipro HC - ciprofloxacin hydrochloride with hydrocortisone Brand names: Cipro XR, Cipro HC Otic, Cipro, Cipro HC Why are Cipro and Cipro HC prescribed? Ciprofloxacin is an antibiotic used to treat infections of the l more...

Folic Acid Capsules Folic Acid Capsules
Generic Name: Folic Acid Capsules and Tablets (FOE-lik ASS-id) Brand Name: FA-8Folic Acid Capsules is used for:Treating certain types of anemia. It may also be used for other conditions as determined by your doctor. Folic Acid Capsules is a vitamin. It works by helping the body to produce blood more...

Fortovase Fortovase
Generic name: Saquinavir Brand names: Invirase, Fortovase Why is Fortovase prescribed? Fortovase is used in the treatment of advanced human immunodeficiency virus (HIV) infection. HIV causes the immune system to break down so that it can no longer fight off other infections. This leads to the fa more...

Mucomyst-10 Mucomyst-10
Some commonly used brand names are: In the U.S.- Mucomyst Mucomyst-10 Mucosil In Canada- Mucomyst Generic name product may be available in the U.S. Another commonly used name is N -acetylcysteine. Category Mucolytic; diagnostic aid (bronchial studies) Description Acetylcysteine (a-se more...

Orlistat Orlistat
Generic name: Orlistat Brand names: Xenical Why is Orlistat prescribed? Xenical blocks absorption of dietary fat into the bloodstream, thereby reducing the number of calories you get from a meal. At the usual dosage level, it cuts fat absorption by almost one-third. Combined with a low-calorie d more...

Prilosec Prilosec
Generic name: Omeprazole Brand names: Prilosec Why is Prilosec prescribed? Prilosec is prescribed for the short-term treatment (4 to 8 weeks) of the following: Stomach ulcer Duodenal ulcer (near the exit from the stomach) Erosive esophagitis (inflammation of the esophagus) Heartburn and other s more...

Propafenone Propafenone
Generic Name: Propafenone Tablets (proe-pa-FEEN-none) Brand Name: RythmolPropafenone has not been shown to improve the rate of survival in patients with an abnormal heart rhythm. For this reason, Propafenone should only be used for certain life-threatening abnormal heart rhythms. Talk with you more...