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All about: Desoxyn Gradumet

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Generic Name: methamphetamine (meth am FET a meen)
Brand Names: Desoxyn, Desoxyn Gradumet

What is Desoxyn Gradumet (methamphetamine)?

Methamphetamine is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Methamphetamine is used to treat attention deficit hyperactivity disorder (ADHD). It is also used to treat obesity after other diets or medications have been tried without successful weight loss.

Methamphetamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Desoxyn Gradumet (methamphetamine)?

Do not use methamphetamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take methamphetamine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to methamphetamine, or if you have hardened arteries (arteriosclerosis), heart disease, moderate to severe high blood pressure (hypertension), overactive thyroid, glaucoma, severe anxiety or agitation, or a history of drug or alcohol addiction. Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Before taking methamphetamine, tell your doctor if you have any type of heart problems. Do not give this medication to a child younger than 12 years old without the advice of a doctor.

Long-term use of methamphetamine can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

Methamphetamine is a drug of abuse and may be habit-forming. Keep track of how many pills have been used from each new bottle of this medicine. You should be aware if any person in the household is using this medicine improperly or without a prescription. Using this medication improperly can cause death or serious side effects on the heart.

What should I discuss with my doctor before taking Desoxyn Gradumet (methamphetamine)?

Do not use methamphetamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take methamphetamine before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to methamphetamine or if you have:

  • heart disease or moderate to severe high blood pressure (hypertension);

  • arteriosclerosis (hardening of the arteries);

  • overactive thyroid;

  • glaucoma;

  • severe anxiety, tension, or agitation; or

  • if you have a history of drug or alcohol addiction.

Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects.

Before using methamphetamine, tell your doctor if you are allergic to any drugs, or if you have:

  • a congenital heart defect;

  • high blood pressure;

  • heart failure, heart rhythm disorder, or recent heart attack;

  • a personal or family history of mental illness, psychotic disorder, bipolar illness, depression, or suicide attempt;

  • diabetes; or

  • tics (muscle twitches) or Tourette's syndrome.

If you have any of these conditions, you may not be able to use methamphetamine, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. It could also cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes methamphetamine during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Methamphetamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Long-term use of methamphetamine can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

Do not give this medication to a child younger than 12 years old without the advice of a doctor.

How should I take Desoxyn Gradumet (methamphetamine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take this medication with a full glass of water.

Do not take methamphetamine in the evening because it may cause sleep problems (insomnia).

If you are taking methamphetamine for weight loss and your appetite gradually increases, do not take more of the medication to suppress appetite. Stop taking methamphetamine and call your doctor.

To be sure this medication is helping your condition, your doctor will need to see you on a regular basis. Do not miss any scheduled visits.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using methamphetamine.

Store methamphetamine at room temperature away from moisture, heat, and light. Methamphetamine is a drug of abuse and may be habit-forming. Keep track of how many pills have been used from each new bottle of this medicine. You should be aware if any person in the household is using this medicine improperly or without a prescription. Using this medication improperly can cause death or serious side effects on the heart.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, or if it is already evening, skip the missed dose and take the medicine the next morning. Taking this medicine late in the day can cause sleep problems. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methamphetamine can be fatal.

Symptoms of a methamphetamine overdose include restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, panic, aggressiveness, unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. These symptoms may be followed by depression and tiredness. Other overdose symptoms include nausea, vomiting, diarrhea, stomach pain, uneven heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma.

What should I avoid while taking Desoxyn Gradumet (methamphetamine)?

Methamphetamine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not take methamphetamine late in the day. A dose taken too late in the day can cause sleep problems (insomnia).

Avoid drinking fruit juices or taking vitamin C at the same time you take methamphetamine. These can make your body absorb less of the medicine.

Desoxyn Gradumet (methamphetamine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using methamphetamine and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeats;

  • feeling light-headed, fainting;

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or

  • tremor, restlessness, hallucinations, unusual behavior, or motor tics (muscle twitches).

Continue taking methamphetamine and talk to your doctor if you have any of these less serious side effects:

  • headache or dizziness;

  • sleep problems (insomnia);

  • dry mouth or an unpleasant taste in your mouth;

  • diarrhea, constipation;

  • loss of appetite, weight loss; or

  • loss of interest in sex, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Desoxyn Gradumet (methamphetamine)?

Before taking methamphetamine, tell your doctor if you are using any of the following drugs:

  • insulin;

  • cold medicines (decongestants);

  • guanethidine (Ismelin);

  • phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine); or

  • antidepressants such as amitriptyline (Elavil), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor).

If you are using any of these drugs, you may not be able to use methamphetamine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect methamphetamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has information about methamphetamine written for health professionals that you may read.

What does my medication look like?

Methamphetamine is available with a prescription under the brand name Desoxyn. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Desoxyn 5 mg--white tablets

  • Desoxyn Gradumet 5 mg (long-acting)--round, white tablets

  • Desoxyn Gradumet 10 mg (long-acting)--round, orange tablets

  • Desoxyn Gradumet 15 mg (long-acting)--round, yellow tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.04. Revision Date: 2/23/07 12:55:10 PM.

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