24 . September , 2018 - Monday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Docusate

Big Image Pronouncation: (DOCK-you-sate)
Class: Fecal softener, Sulfactant Docusate Sodium (Dioctyl Sodium Sulfosuccinate; DSS)

Trade Names:
Colace
- Capsules 50 mg
- Capsules 100 mg
- Liquid 150 mg/15 mL
- Syrup 60 mg/15 mL

Trade Names:
Diocto
- Liquid 150 mg/15 mL
- Syrup 60 mg/15 mL

Trade Names:
Docu
- Liquid 150 mg/15 mL
- Syrup 20mg/5 mL

Trade Names:
D.O.S
- Capsules, soft-gel 100 mg
- Capsules, soft-gel 250 mg

Trade Names:
D-S-S
- Capsules 100 mg

Trade Names:
ex-lax Stool Softener
- Tablets 100 mg

Trade Names:
Genasoft
- Capsules, soft-gel 100 mg

Trade Names:
Non-Habit Forming Stool Softener
- Capsules 100 mg

Trade Names:
Phillips' Liqui-Gels
- Capsules, soft-gel 100 mg

Trade Names:
Regulax SS
- Capsules 100 mg

Trade Names:
Silace
- Syrup 60 mg/15 mL

Trade Names:
Stool Softener
- Capsules 100 mg
- Capsules 250 mg

Selax (Canada)
Soflax (Canada)
ratio-Docusate Sodium (Canada)
Docusate Calcium (Dioctyl Calcium Sulfosuccinate)

Trade Names:
DC Softgels
- Capsules 240 mg

Trade Names:
Stool Softener
- Capsules 240 mg

Trade Names:
Stool Softener DC
- Capsules 240 mg

Trade Names:
Surfak Liquigels
- Capsules 240 mg

ratio-Docusate Calcium (Canada)

Mechanism of Action

Pharmacology

Facilitates stool softening by detergent activity.

Pharmacokinetics

Onset

12 to 72 h.

Indications and Usage

Short-term treatment of constipation; prophylaxis in patients who should not strain during defecation (eg, after anorectal surgery, MI); to evacuate the colon for rectal and bowel examinations; prevention of dry, hard stools.

Contraindications

Nausea, vomiting or other symptoms of appendicitis; acute surgical abdomen; fecal impaction; intestinal obstruction; undiagnosed abdominal pain; coadministration with mineral oil.

Dosage and Administration

Docusate Sodium
Adults and Children older than 12 yr of age

PO 50 to 500 mg.

Children 6 to 12 yr of age

PO 40 to 120 mg.

Children 3 to 6 yr of age

PO 20 to 60 mg.

Children younger than 3 yr of age

PO 10 to 40 mg.

Docusate Calcium
Adults

PO 240 mg.

Children 6 yr of age and older and Adults With Minimal Needs

PO 50 to 150 mg.

General Advice

  • Administer each dose with full glass of water.
  • Do not open or otherwise alter capsules.

Storage/Stability

Store capsules at room temperature. Protect liquid preparations from light.

Drug Interactions

Mineral oil

Docusate may increase absorption of mineral oil from GI tract, leading to toxicity.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Palpitations.

CNS

Dizziness; fainting.

GI

Excessive bowel activity (griping, diarrhea, nausea, vomiting); perianal irritation; bloating; flatulence; abdominal cramping.

Miscellaneous

Sweating; weakness.

Precautions

Monitor

Evaluate and document patient's response to stool softener, noting any adverse reactions such as nausea, vomiting, abdominal cramping, or diarrhea.


Pregnancy

Category C .

Lactation

Undetermined.

Abuse/dependence

Long-term use may lead to laxative dependence, fluid and electrolyte imbalances, steatorrhea, osteomalacia, and vitamin and mineral deficiencies.

Fluid and electrolyte imbalance

Excessive laxative use may lead to significant fluid and electrolyte imbalance.

Rectal bleeding or failure to respond

May indicate serious condition that may require further medical attention.

Concomitant laxative use

Do not use other laxatives, especially during the initial phase of therapy for portal-systemic encephalopathy; the resulting loose stools may falsely suggest adequate lactulose dosage.

Patient Information

  • Tell patient to drink full glass of water with each dose.
  • Instruct patient to swallow tablets whole and not to chew them.
  • Instruct patient not to use mineral oil while taking this drug.
  • Teach patient other methods of stimulating regular bowel evacuation: attempt to evacuate bowels at same time each day; drink 6 to 8 full glasses of water; eat high-fiber diet; exercise daily; respond to urge for bowel movement as soon as possible.
  • Explain that liquid forms, excluding syrup, may be mixed with fruit juice or milk to mask unpleasant taste.

Recent Drug Updates at DrugIndexOnline:





Advil Allergy Sinus Advil Allergy Sinus
Generic Name: chlorpheniramine, ibuprofen, and pseudoephedrine (klor fen EER a meen, I byoo PRO fen, soo doh ee FED rin) Brand Names: Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold What is chlorpheniramine, ibuprofen, and pseudoephedrine? Chlorpheniramine is more...

Alprostadil Alprostadil
Generic name: Alprostadil Brand names: Edex, Muse, Caverject Why is Alprostadil prescribed? Caverject is used to treat male impotence. Your doctor also may use Caverject to help diagnose the exact nature of your impotence. Caverject and the similar brand Edex are both taken by injection. A third more...

Ethinyl Estradiol/Ethynodiol Ethinyl Estradiol/Ethynodiol
Generic Name: Ethynodiol/Ethinyl Estradiol (e-thye-noe-DYE-ole/ETH-in-il ess-trah-DYE-ole) Brand Name: Examples include Demulen and ZoviaCigarette smoking while taking Ethinyl Estradiol/Ethynodiol increases the risk of serious heart problems. The risk increases with age (older than 35 years) a more...

Glucose Chewable Tablets Glucose Chewable Tablets
Generic Name: Glucose Chewable Tablets (GLOO-kose) Brand Name: BD GlucoseGlucose Chewable Tablets is used for:Treating reactions caused by low blood glucose (sugar). Glucose Chewable Tablets is a monosaccharide (simple sugar). It works by quickly raising the glucose level in the blood. Do NOT us more...

Ircon Ircon
Generic Name: ferrous fumarate (FEHR russ FEW ma rate) Brand Names: Femiron, Feostat, Ferret, Fumasorb, Hemocyte, Ircon, Nephro-Fer What is Ircon (ferrous fumarate)? Ferrous fumarate is a form of the mineral iron. Iron is important for many functions in the body, especially for the tran more...

Isocal Isocal
Some commonly used brand names are: In the U.S.— Accupep HPF 9 Advera 2 Alitraq 9 Amin-Aid 2 Attain 10 Carnation Instant Breakfast 7 Carnation Instant Breakfast No Sugar Added 7 Casec 8 CitriSource 10 Compleat Modified 1 Compleat Regular 1 Comply 10 Criticare HN 9 Crucial 2 Deliver 2.0 10 more...

Lunelle Lunelle
Some commonly used brand names are: In the U.S.— Lunelle Description Contraceptives are designed to prevent pregnancy. The combination of medroxyprogesterone (me-DROX-ee-proe-JES-ter-rone)and estradiol (es-tra-DYE-ole)are two types of hormones that work by stopping a women's egg from more...

PreSun Moisturizing Sunscreen with Keri Topical PreSun Moisturizing Sunscreen with Keri Topical
Some commonly used brand names are: In the U.S.— A-Fil 33 Aquaderm Sunscreen Moisturizer 49 Aquaray Sunscreen 42 Bain de Soleil All Day For Kids 38 Bain de Soleil All Day Sunfilter 39 Bain de Soleil Mega Tan 34 Bain de Soleil Orange Gelee 41 Bain de Soleil Sand Buster 41 Bain de Soleil SP more...