25 . April , 2018 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Docusate

Big Image Pronouncation: (DOCK-you-sate)
Class: Fecal softener, Sulfactant Docusate Sodium (Dioctyl Sodium Sulfosuccinate; DSS)

Trade Names:
- Capsules 50 mg
- Capsules 100 mg
- Liquid 150 mg/15 mL
- Syrup 60 mg/15 mL

Trade Names:
- Liquid 150 mg/15 mL
- Syrup 60 mg/15 mL

Trade Names:
- Liquid 150 mg/15 mL
- Syrup 20mg/5 mL

Trade Names:
- Capsules, soft-gel 100 mg
- Capsules, soft-gel 250 mg

Trade Names:
- Capsules 100 mg

Trade Names:
ex-lax Stool Softener
- Tablets 100 mg

Trade Names:
- Capsules, soft-gel 100 mg

Trade Names:
Non-Habit Forming Stool Softener
- Capsules 100 mg

Trade Names:
Phillips' Liqui-Gels
- Capsules, soft-gel 100 mg

Trade Names:
Regulax SS
- Capsules 100 mg

Trade Names:
- Syrup 60 mg/15 mL

Trade Names:
Stool Softener
- Capsules 100 mg
- Capsules 250 mg

Selax (Canada)
Soflax (Canada)
ratio-Docusate Sodium (Canada)
Docusate Calcium (Dioctyl Calcium Sulfosuccinate)

Trade Names:
DC Softgels
- Capsules 240 mg

Trade Names:
Stool Softener
- Capsules 240 mg

Trade Names:
Stool Softener DC
- Capsules 240 mg

Trade Names:
Surfak Liquigels
- Capsules 240 mg

ratio-Docusate Calcium (Canada)

Mechanism of Action


Facilitates stool softening by detergent activity.



12 to 72 h.

Indications and Usage

Short-term treatment of constipation; prophylaxis in patients who should not strain during defecation (eg, after anorectal surgery, MI); to evacuate the colon for rectal and bowel examinations; prevention of dry, hard stools.


Nausea, vomiting or other symptoms of appendicitis; acute surgical abdomen; fecal impaction; intestinal obstruction; undiagnosed abdominal pain; coadministration with mineral oil.

Dosage and Administration

Docusate Sodium
Adults and Children older than 12 yr of age

PO 50 to 500 mg.

Children 6 to 12 yr of age

PO 40 to 120 mg.

Children 3 to 6 yr of age

PO 20 to 60 mg.

Children younger than 3 yr of age

PO 10 to 40 mg.

Docusate Calcium

PO 240 mg.

Children 6 yr of age and older and Adults With Minimal Needs

PO 50 to 150 mg.

General Advice

  • Administer each dose with full glass of water.
  • Do not open or otherwise alter capsules.


Store capsules at room temperature. Protect liquid preparations from light.

Drug Interactions

Mineral oil

Docusate may increase absorption of mineral oil from GI tract, leading to toxicity.

Laboratory Test Interactions

None well documented.

Adverse Reactions




Dizziness; fainting.


Excessive bowel activity (griping, diarrhea, nausea, vomiting); perianal irritation; bloating; flatulence; abdominal cramping.


Sweating; weakness.



Evaluate and document patient's response to stool softener, noting any adverse reactions such as nausea, vomiting, abdominal cramping, or diarrhea.


Category C .




Long-term use may lead to laxative dependence, fluid and electrolyte imbalances, steatorrhea, osteomalacia, and vitamin and mineral deficiencies.

Fluid and electrolyte imbalance

Excessive laxative use may lead to significant fluid and electrolyte imbalance.

Rectal bleeding or failure to respond

May indicate serious condition that may require further medical attention.

Concomitant laxative use

Do not use other laxatives, especially during the initial phase of therapy for portal-systemic encephalopathy; the resulting loose stools may falsely suggest adequate lactulose dosage.

Patient Information

  • Tell patient to drink full glass of water with each dose.
  • Instruct patient to swallow tablets whole and not to chew them.
  • Instruct patient not to use mineral oil while taking this drug.
  • Teach patient other methods of stimulating regular bowel evacuation: attempt to evacuate bowels at same time each day; drink 6 to 8 full glasses of water; eat high-fiber diet; exercise daily; respond to urge for bowel movement as soon as possible.
  • Explain that liquid forms, excluding syrup, may be mixed with fruit juice or milk to mask unpleasant taste.

Recent Drug Updates at DrugIndexOnline:

Carbastat Ocular Carbastat Ocular
Generic Name: Carbachol Ocular Injection (KAR-ba-kol) Brand Name: Examples include Carbastat and MiostatCarbastat Ocular is used for:Contracting the pupil during and immediately following surgery. It is also reduces eye pressure in the first 24 hours after cataract surgery. Carbastat Ocular is more...

Chlorambucil Chlorambucil
Some commonly used brand names are: In the U.S.— Leukeran In Canada— Leukeran Category Antineoplastic Immunosuppressant Description Chlorambucil (klor-AM-byoo-sill) belongs to the group of medicines called alkylating agents. It is used to treat cancer of the blood and lym more...

Co-Lav Local Co-Lav Local
Some commonly used brand names are: In the U.S.— Co-Lav Colovage Colyte Colyte-flavored Colyte with Flavor Packs Go-Evac GoLYTELY NuLYTELY NuLYTELY, Cherry Flavor OCL In Canada— Colyte GoLYTELY Klean-Prep Peglyte PEG-3350 & Electrolytes Category Evacuant (bowel) Descr more...

I-L-X and B12 I-L-X and B12
Generic Name: multivitamins with iron (mull tee VYE tah mins with i ron) Brand Names: Allbee-C 800 with Iron, Anemagen, Anemagen FA, Bugs Bunny with Iron Chewable, Chromatinic, Contrin, Dayalets Plus Iron, Diatx Fe, Equi-Roca Plus, Equicyte Plus, Fe-Tinic 150 Forte, Femiron Multi with Iro more...

influenza virus vaccine injectable influenza virus vaccine injectable
Generic Name: influenza virus vaccine (injectable) (in floo ENZ a VYE rus VAK seen) Brand Names: Fluarix, Fluogen, Flushield, Fluvirin, Fluzone What is influenza virus injectable vaccine? Influenza virus (commonly known as "the flu") is a serious disease caused by a virus. Influenza more...

KGS-PE Liquid KGS-PE Liquid
Generic Name: Phenylephrine/Potassium Guaiacolsulfonate Liquid (fen-ill-EF-rin/poe-TASS-ee-uhm gwie-ah-kole-SULL-foe-nate) Brand Name: KGS-PEKGS-PE Liquid is used for:Relieving symptoms of congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used fo more...

Lotriderm Topical Lotriderm Topical
Some commonly used brand names are: In the U.S.— Lotrisone In Canada— Lotriderm Category Antifungal-corticosteroid, topical Description Clotrimazole and betamethasone (kloe-TRIM-a-zole and bay-ta-METH-a-sone) combination is used to treat fungus infections. Clotrimazole wo more...

Mevacor Mevacor
Generic Name: lovastatin (LOE va sta tin) Brand Names: Altocor, Mevacor What is Mevacor (lovastatin)? Lovastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. Lovastatin reduces low-density lipoprotein (LDL) cholesterol and t more...