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All about: Dolorex

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Generic Name: Acetaminophen/Salicylamide/Phenyltoloxamine (aH-seet-ah-MIN-oh-fen/SAL-ih-sill-ah-mide/fen-ill-tole-OX-a-meen)
Brand Name: Examples include Dolorex and Duraxin

Dolorex is used for:

Treating mild to moderate aches and pains associated with headache, muscle and joint soreness, backache, menstrual cramps, colds and flu, sinusitis, toothache, and minor pain from arthritis, and to reduce fever. It may also be used to treat other conditions as determined by your doctor.

Dolorex is an analgesic, antihistamine, and antipyretic combination. It works by blocking substances in the body that cause fever, pain, and inflammation. It also blocks histamine, which causes sneezing and itchy, watery eyes.

Do NOT use Dolorex if:

  • you are allergic to any ingredient in Dolorex
  • you have lung problems (asthma, emphysema, chronic obstructive pulmonary disease [COPD]), difficulty urinating due to an enlarged prostate, glaucoma, kidney or liver problems, or blood clotting problems
  • you are taking medicine for blood clotting or sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dolorex :

Some medical conditions may interact with Dolorex . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bleeding problems, blood vessel problems in the brain, blockage of the stomach, chickenpox, flu, rheumatoid arthritis, Kawasaki syndrome, prostate problems, blockage of the urinary tract, or difficulty urinating

Some MEDICINES MAY INTERACT with Dolorex . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Isoniazid or sodium oxybate because the risk of side effects may be increased
  • Blood thinners (eg, warfarin) because the risk of side effects, including the risk of bruising or bleeding, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dolorex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dolorex :

Use Dolorex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Dolorex with food and a large glass of water or milk to reduce stomach irritation.
  • If you miss a dose of Dolorex and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dolorex .

Important safety information:

  • Dolorex may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dolorex . Using Dolorex alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Dolorex contains acetaminophen. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.
  • Avoid taking medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Dolorex . Dolorex will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Do not exceed the recommended dosage or take Dolorex for longer than prescribed without checking with your doctor.
  • If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Dolorex or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Dolorex may increase your risk for liver damage.
  • If you are taking Dolorex for pain or fever and your symptoms do not improve within 10 days or if they become worse, check with your doctor.
  • Before you have any medical or dental treatments or surgery, tell the doctor or dentist that you are taking Dolorex .
  • Do not give Dolorex to a child or teenager who has chickenpox, the flu, or another viral infection. Use of Dolorex for treating the symptoms of a viral infection may cause a serious illness called Reye syndrome.
  • Dolorex is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been established.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dolorex during pregnancy. Dolorex is excreted in breast milk. Do not breast-feed while taking Dolorex .

Possible side effects of Dolorex :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth, nose, or throat; heartburn; nausea; thickening of mucus in the nose and throat; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black stools; confusion; dark urine or pale stools; decreased urination; diarrhea; difficulty swallowing; dizziness; hearing loss; hoarseness; persistent sore throat or other signs of infection; ringing in the ears; severe stomach pain; unusual bruising or bleeding; unusual tiredness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include abnormal behavior; dark urine; excessive sweating; extreme tiredness; fast or deep breathing; loss of consciousness; ringing in the ears; stomach pain; vomiting.

Proper storage of Dolorex :

Store at room temperature, 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dolorex out of the reach of children and away from pets.

General information:

  • If you have any questions about Dolorex , please talk with your doctor, pharmacist, or other health care provider.
  • Dolorex is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Dolorex . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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