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All about: Alendronate Solution

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Generic Name: Alendronate Oral Solution (a-LEN-droe-nate)
Brand Name: Fosamax

Alendronate Solution is used for:

Treating and preventing osteoporosis in certain patients. It may also be used for other conditions as determined by your doctor.

Alendronate Solution is a bisphosphonate. It works by slowing bone loss.

Do NOT use Alendronate Solution if:

  • you are allergic to any ingredient in Alendronate Solution
  • you have certain esophagus problems (eg, narrowing, blockage)
  • you are unable to stand or sit upright for at least 30 minutes
  • you have low blood calcium levels or severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Alendronate Solution:

Some medical conditions may interact with Alendronate Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of stomach or bowel problems (eg, inflammation, ulcer), esophagus problems (eg, heartburn, reflux disease, severe irritation), or kidney problems, or if you have difficult or painful swallowing
  • if you are bedridden or have a history of aspiration
  • if you have low blood vitamin D levels, mental problems, cancer, anemia, blood clotting problems, an infection, or calcium metabolism problems
  • if you have poor dental hygiene, other dental problems, or you will be having a dental procedure
  • if you smoke or drink alcohol
  • if you take a corticosteroid (eg, prednisone), or you have had or will be having chemotherapy or radiation treatment

Some MEDICINES MAY INTERACT with Alendronate Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of side effects, such as esophagus or stomach irritation, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Alendronate Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Alendronate Solution:

Use Alendronate Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Alendronate Solution. Talk to your pharmacist if you have questions about this information.
  • Be sure you understand how much of Alendronate Solution to take for your dose.
  • Take Alendronate Solution by mouth on an empty stomach in the morning at least 30 minutes before your first food, drink, or other medicine of the day. Do NOT take Alendronate Solution at bedtime or before you get out of bed in the morning.
  • Drink at least 2 oz (1/4 cup) of plain water after you take Alendronate Solution. Do not take Alendronate Solution with mineral water, coffee, tea, or juice. Do not lie down for 30 minutes after taking Alendronate Solution and until you eat your first food of the day.
  • Alendronate Solution is usually taken 1 time each week. Be sure you understand how to take Alendronate Solution. Contact your doctor or pharmacist if you have any questions.
  • Continue to use Alendronate Solution even if you feel well. Do not miss any doses.
  • If you miss a dose of Alendronate Solution, do not take it later in the day. Take it the morning after you remember, and then go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Alendronate Solution.

Important safety information:

  • Alendronate Solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Alendronate Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Talk with your doctor before you drink alcohol, smoke, or use other tobacco products while taking Alendronate Solution.
  • Follow the diet and exercise program given to you by your health care provider. Talk to your doctor about whether you should take a calcium and vitamin D supplement while you use Alendronate Solution.
  • Talk to your doctor about the use of weight-bearing exercises to help prevent weak bones.
  • Alendronate Solution may cause jaw bone problems in some patients. Your risk may be greater if you have cancer, poor dental hygiene, or certain other conditions (eg, anemia, blood clotting problems, infection, dental problems). You risk may also be greater if you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use Alendronate Solution. Ask your doctor any questions you may have about dental treatment while you use Alendronate Solution.
  • Proper dental care is important while you are taking Alendronate Solution. Brush and floss your teeth and visit the dentist regularly.
  • Alendronate Solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Alendronate Solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Alendronate Solution before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including bone density and blood calcium levels, may be performed while you use Alendronate Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Alendronate Solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Alendronate Solution while you are pregnant. It is not known if Alendronate Solution is found in breast milk. If you are or will be breast-feeding while you use Alendronate Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Alendronate Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bone, muscle, or joint pain; constipation; diarrhea; dizziness; feeling bloated or full; flu-like symptoms at the start of treatment; gas; headache; mild stomach pain; nausea; taste changes; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; chest pain; coughing or vomiting blood; difficult or painful swallowing; mouth sores; new, worsening, or severe heartburn; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain; severe or persistent sore throat or stomach pain; swelling of the hands, legs, or joints; swelling or pain in your jaw.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Drink a full glass (8 oz/240 mL) of milk. Do not lie down for at least 30 minutes or as directed by your doctor. Do not try to vomit. Symptoms may include painful swallowing; severe heartburn; stomach pain or upset.

Proper storage of Alendronate Solution:

Store Alendronate Solution at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Alendronate Solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Alendronate Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Alendronate Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Alendronate Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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