26 . May , 2018 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Dutasteride

Big Image Pronouncation: (Doo-TASS-teer-ide)
Class: Androgen hormone inhibitor

Trade Names:
Avodart
- Capsules 0.5 mg

Mechanism of Action

Pharmacology

Inhibits the conversion of testosterone to 5-alpha-dihydrotestosterone, a potent androgen.

Pharmacokinetics

Absorption

T max is 2 to 3 h; bioavailability is approximately 60%; administration with food decreased C max 10% to 15%.

Distribution

Vd is 300 to 500 L; highly protein bound.

Metabolism

Metabolized by CYP3A4.

Elimination

Mainly excreted in feces (approximately 5% as unchanged dutasteride and approximately 40% as metabolites). The t ½ is approximately 5 wk.

Indications and Usage

Treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate.

Contraindications

Women; children; hypersensitivity to 5-alpha-reductase inhibitors or any component of the product.

Dosage and Administration

Adults

PO 0.5 mg once daily.

General Advice

  • Swallow capsules whole. Do not crush, cut, or chew.
  • Do not use capsules that are cracked or leaking.

Storage/Stability

Store at controlled room temperature (59° to 86°F). Protect from light.

Drug Interactions

CYP-450 3A4 inhibitors (eg, cimetidine, ciprofloxacin, diltiazem, ketoconazole, ritonavir, verapamil)

Plasma concentrations of dutasteride may be elevated, increasing the risk of adverse reactions.

Laboratory Test Interactions

Decreased prostate-specific antigen levels.

Adverse Reactions

Genitourinary

Impotence; decreased libido; ejaculation disorder; gynecomastia.

Precautions

Pregnancy

Category X .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Hepatic Function

Use with caution.

Handling capsules

Women who are not pregnant should use caution whenever handling dutasteride capsules. If contact is made with leaking capsules, wash the contacted area immediately with soap and water.

Obstructive uropathy

Carefully monitor patients with large residual urine volume or severely diminished urinary flow.

Patient Information

  • Advise patient to read the patient information leaflet before starting dutasteride and with each refill.
  • Advise patient that prescribed dose is to be taken once daily without regard to meals and to try to take the dose at about the same time each day.
  • Advise patient that if a dose is missed to take as soon as remembered but to never take 2 doses the same day.
  • Advise patient that drug does not work immediately and that it may take 3 to 6 mo to experience maximum benefit.
  • Advise patient that ejaculate volume may be decreased during treatment but that this decrease does not interfere with normal sexual function.
  • Instruct patient to not stop taking dutasteride when symptoms have improved.
  • Caution patient that women who are or may be pregnant should not handle the medication because of risk of absorption though the skin and risk to developing male fetus.
  • Caution patient that a woman who is not pregnant can handle the capsules with caution but if contact is made with a leaking capsule to wash the contacted area immediately with soap and water.
  • Advise patient that impotence, decreased libido, and ejaculation disorder may occur with therapy but that these symptoms should lessen as treatment continues.
  • Advise patient against donating blood for at least 6 mo following discontinuation of therapy to prevent pregnant women from receiving dutasteride through a blood transfusion.

Recent Drug Updates at DrugIndexOnline:





Desmopressin Tablets Desmopressin Tablets
Generic Name: Desmopressin acetate Dosage Form: Tablets 1002320102 Rx only DESCRIPTION: Desmopressin acetate are a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), is an antidiuretic hormone affecting renal water conservation. It is chemically defined as 1-(3-mer more...

Diflucan-150 Diflucan-150
Some commonly used brand names are: In the U.S.— Diflucan 1 Nizoral 3 Sporanox 2 In Canada— Diflucan 1 Diflucan-150 1 Nizoral 3 Sporanox 2 Note: For quick reference, the following antifungals are numbered to match the corresponding brand names. This information applies more...

Foamicon Foamicon
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...

Hyosophen Hyosophen
Generic Name: belladonna alkaloids and phenobarbital (bell uh DAHN uh AL kuh loydz and feen oh BAR bih tall) Brand Names: Antispas, Antispasmodic, Barbidonna, Donnapine, Donnatal, Donnatal Extentabs, Elixiral, Hyosophen, Spasmolin What is Hyosophen (belladonna alkaloids and phenobarbital more...

Imdur Imdur
Generic Name: isosorbide mononitrate (eye soe SORE bide) Brand Names: Imdur, ISMO, Monoket What is isosorbide mononitrate? Isosorbide mononitrate is in a class of drugs called nitrates. Isosorbide mononitrate dilates (widens or relaxes) blood vessels (arteries and veins). When blood vess more...

Losopan Plus Losopan Plus
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...

Miacalcin Spray Miacalcin Spray
Generic Name: Calcitonin Salmon Nasal Spray (KAL-si-TOE-nin SA-mon) Brand Name: Examples include Fortical and MiacalcinMiacalcin Spray is used for:Treating osteoporosis (fragile or brittle bones) in certain women who have been past menopause for more than 5 years. It should be used along with a more...

Neulasta Neulasta
Generic Name: Pegfilgrastim (peg-fil-GRAS-tim) Brand Name: NeulastaNeulasta is used for:Decreasing the incidence of infection in certain cancer patients undergoing myelosuppressive cancer treatments. Neulasta is an amino acid. It works by stimulating bone marrow to produce white blood cells, w more...