23 . January , 2019 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Alglucerase

Big Image Pronouncation: (al-GLOO-ser-ase)
Class: Enzyme replacement

Trade Names:
- Solution for injection 80 units/mL

Mechanism of Action


Catalyzes the hydrolysis of glucocerebroside to glucose and ceramide as part of the normal degradation pathway for membrane lipids.



Steady-state enzymatic activity and AUC of the activity increased linearly with the infused dose.


Vd ranged from 49.4 to 282.1 mL/kg.


Plasma Cl, based on plasma enzymatic activity, ranged from 6.34 to 25.39 mL/min/kg.


Following IV infusion over a 4-h period, steady-state enzymatic activity is achieved by 60 min.


Following infusion termination, plasma enzymatic activity declined rapidly with an elimination t ½ ranging from 3.6 to 10.4 min.

Indications and Usage

Long-term replacement therapy for patients with confirmed diagnosis of type 1 Gaucher disease who exhibit signs and symptoms severe enough to result in moderate to severe anemia, thrombocytopenia with bleeding tendency, bone disease, and/or hepatomegaly or splenomegaly.

Unlabeled Uses

Orphan drug status for replacement therapy in types 2 and 3 Gaucher disease.


Standard considerations.

Dosage and Administration

Adults and children 2 yr of age and older

IV Infuse dose over 1 to 2 h. Individualize dosage. Initial dosage may be as little as 2.5 units/kg 3 times a week up to 60 units/kg as frequently as once a week or as infrequently as every 4 wk. After response is well established, a reduction in dosage may be attempted for maintenance therapy. Progressive reductions can be made at intervals of 3 to 6 mo while carefully monitoring response parameters.

General Advice

  • Do not shake.
  • Inspect for particulate matter and discoloration before use.


Store at 36° to 46°F. When diluted to 100 to 200 mL, product is stable for up to 18 h when stored at 36° to 46°F.

Drug Interactions

None well documented.

Laboratory Test Interactions

False-positive pregnancy test.

Adverse Reactions


Hypotension, vasomotor irritability or hot flash.


Fatigue, headache, weakness.


Impaired sense of smell.


Diarrhea, nausea, oral ulcers, vomiting.


Menstrual abnormalities.


Burning and swelling or sterile abscess at venipuncture site, discomfort, pruritus.




Abdominal discomfort, chills, hypersensitivity (abdominal cramping, chest discomfort, flushing, nausea, pruritus, respiratory symptoms, urticaria/angioedema with occasional upper airway involvement), slight fever, transient peripheral edema.



Category C .


May be excreted in breast milk.


Safety and efficacy not established in children younger than 2 yr of age.


Use with caution in patients exhibiting symptoms of hypersensitivity; pretreatment with antihistamines has allowed continued use in some patients.

Special Risk Patients

Use with caution in patients with androgen-sensitive malignancies.


Approximately 13% of patients may develop immunoglobulin G antibody during first yr of therapy, of which 25% may experience symptoms of hypersensitivity.


Because alglucerase is prepared from pooled human placental tissue, there is a risk of transmission of infectious agents (eg, viruses), including Creutzfeldt-Jakob disease.



No obvious toxicity detected after doses up to 234 units/kg.

Patient Information

  • Advise patient that this medicine is usually administered at health care provider's office, hospital, or clinic.
  • Advise patient who is using the medicine at home to follow the injection procedures taught by health care provider.

Recent Drug Updates at DrugIndexOnline:

Certain Dri Solution Certain Dri Solution
Generic Name: Aluminum Chloride Solution (a-LOO-mi-num) Brand Name: Examples include Certain Dri and DrysolCertain Dri Solution is used for:Treating excess perspiration (sweating) problems. Certain Dri Solution is an antiperspirant. It is thought to work by altering the sweat-producing cells in more...

DermiCort Topical DermiCort Topical
Some commonly used brand names are: In the U.S.— Aclovate 1 Acticort 100 7 Aeroseb-Dex 4 Aeroseb-HC 7 Ala-Cort 7 Ala-Scalp HP 7 Allercort 7 Alphaderm 7 Bactine 7 Beta-HC 7 CaldeCORT Anti-Itch 8 CaldeCORT Light 9 Carmol-HC 9 Cetacort 7 Cloderm 2 Cortaid 8 Cort-Dome 7 Cortef Feminine Itch 9 more...

Dyphylline Dyphylline
Pronouncation: (DIE-fih-lin) Class: Xanthine derivative Trade Names: Lufyllin - Tablets 200 mg - Tablets 400 mg Trade Names: Dylix - Elixir 100 mg per 15 mL Mechanism of Action Pharmacology Relaxes bronchial smooth muscle and stimulates central respiratory drive. Pharmacokinetics Absorption Rapidly more...

grepafloxacin grepafloxacin
Generic Name: grepafloxacin (grep a FLOX a sin) Brand Names: Raxar What is grepafloxacin? Grepafloxacin nasal was withdrawn from the U.S. market in 1999. Grepafloxacin is an antibiotic in a class of drugs called fluoroquinolones. Grepafloxacin fights bacteria in your body. Grepafloxacin more...

Kenalog-10 oral and injectable Kenalog-10 oral and injectable
Generic Name: triamcinolone (oral and injectable) (trye am SIH no lone) Brand Names: Acetocot, Aristocort, Aristopak, Aristospan Injection, Clinacort, Clinalog, Cort-K, Kenaject-40, Kenalog-10, Kenalog-40, TAC 3, Tramacort-D, Triam-A, Triam-Forte, Triamcot, Triamonide 40, Trilog, Trilone, more...

levetiracetam levetiracetam
Generic Name: levetiracetam (lee ve tye RA se tam) Brand Names: Keppra What is levetiracetam? Levetiracetam is an anti-epileptic drug. Levetiracetam is used to treat partial onset seizures in people with epilepsy. Levetiracetam is also used to treat myoclonic seizures and tonic-clonic s more...

Metadate CD Metadate CD
Some commonly used brand names are: In the U.S.— Concerta Metadate CD Ritalin Ritalin LA Ritalin-SR In Canada— PMS-Methylphenidate Riphenidate Ritalin Ritalin SR Generic name product may be available in the U.S. Category Central nervous system stimulant Description Methyl more...

Novantrone Novantrone
Generic Name: mitoxantrone hydrochloride Dosage Form: For injection concentrate BOXED WARNING Novantrone® (mitoxantrone for injection concentrate) should be administered under the supervision of a physician experienced in the use of cytotoxic chemotherapy agents. Novantrone® should be gi more...