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All about: Elitek

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Generic Name: Rasburicase (ras-BYOOR-i-kayse)
Brand Name: Elitek

Elitek can cause a severe allergic reaction. If you develop new symptoms such as chest pain, trouble breathing, severe dizziness, a rash, or hives, stop using Elitek and seek immediate medical attention. Do not restart Elitek if a severe allergic reaction has occurred. Consult your doctor or pharmacist for more details.

Do not take Elitek if you have a metabolic condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency because it can severely damage your red blood cells, leading to anemia (hemolysis). If you are of African or Mediterranean descent, you may be at higher risk for G6PD deficiency and should be tested to see if you have this condition before starting Elitek .

Elitek can cause a condition that affects the ability of your red blood cells to carry oxygen (methemoglobinemia). Do not restart Elitek if this effect occurs. Consult your doctor for more details.

Elitek can interfere with accurate measurements of uric acid in the blood, resulting in falsely low levels. Be sure to tell all lab personnel that you are using Elitek .


Elitek is used for:

Preventing high blood levels of uric acid from occurring in children with cancer (eg, leukemia, lymphoma, solid malignant tumors) who are about to receive cancer chemotherapy treatment.

Elitek is a urate-oxidase enzyme. When chemotherapy is given, cancer cells are destroyed, releasing large amounts of uric acid into the blood. Elitek works by allowing uric acid to be more easily removed from the body by the kidneys.

Do NOT use Elitek if:

  • you are allergic to any ingredient in Elitek
  • you have a metabolic condition called G6PD deficiency or a history of methemoglobinemia (a bluish discoloration to the skin and mucous membranes) or hemolysis from using Elitek

Contact your doctor or health care provider right away if any of these apply to you.

Before using Elitek :

Some medical conditions may interact with Elitek . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney disease or are dehydrated

Some MEDICINES MAY INTERACT with Elitek . However, no specific interactions with Elitek are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Elitek may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Elitek :

Use Elitek as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Elitek is usually administered as an infusion over 30 minutes at your doctor's office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about Elitek .
  • When Elitek is mixed, the vial should not be shaken.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If Elitek contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • If you miss a dose of Elitek , contact your doctor immediately to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Elitek .

Important safety information:

  • Elitek can interfere with the uric acid in blood samples when the blood samples are kept at room temperature. This can cause falsely low uric acid results. Inform all lab personnel that you are using Elitek , because they must follow special procedures to process your blood samples.
  • LAB TESTS, including uric acid levels, will be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Elitek with extreme caution in CHILDREN younger than 2 years of age because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Elitek during pregnancy. It is unknown if Elitek is excreted in breast milk. Do not breast-feed while taking Elitek .

Possible side effects of Elitek :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; mouth sores or ulcers; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue or gray skin color; chest pain; chills; constipation; dark urine; fever; numbness or tingling of the skin; persistent sore throat; severe dizziness; shivering; weakness; yellowing of the eyes and skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Elitek :

Elitek is usually handled and stored by a health care provider. If you are using Elitek at home, store Elitek as directed by your pharmacist or health care provider. Keep Elitek out of the reach of children and away from pets.

General information:

  • If you have any questions about Elitek , please talk with your doctor, pharmacist, or other health care provider.
  • Elitek is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Elitek . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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