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All about: Enfuvirtide

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Generic Name: Enfuvirtide (en-FEW-ver-tide)
Brand Name: Fuzeon

Enfuvirtide is used for:

Treating HIV infection in combination with other anti-HIV medicines.

Enfuvirtide is an antiviral agent. It works by blocking HIV from infecting healthy immune cells (CD4 cells).

Do NOT use Enfuvirtide if:

  • you are allergic to any ingredient in Enfuvirtide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Enfuvirtide :

Some medical conditions may interact with Enfuvirtide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of lung disease or intravenous (IV) drug use, or if you smoke

Some MEDICINES MAY INTERACT with Enfuvirtide . However, no specific interactions with Enfuvirtide are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Enfuvirtide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Enfuvirtide :

Use Enfuvirtide as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

  • Enfuvirtide comes with an additional patient leaflet. Read it carefully and reread it each time you get Enfuvirtide refilled.
  • Food does not affect Enfuvirtide . You may use Enfuvirtide whether you have eaten or not. You must keep taking your other medicines the way you did before you started taking Enfuvirtide .
  • Enfuvirtide is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Enfuvirtide at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Enfuvirtide contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Enfuvirtide is injected under the skin usually twice daily into the upper arm, thigh, or abdomen. Rotate injection sites with each shot. Do not inject in or near bumps from past injections. Also, do not inject into moles, scars, bruises, or your belly button.
  • When drawing a dose into a syringe, be sure to follow the procedure demonstrated to you to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers.
  • Do not mix your other medicines in the same syringe with Enfuvirtide .
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Enfuvirtide , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. It is important not to miss doses of Enfuvirtide .

Ask your health care provider any questions you may have about how to use Enfuvirtide .

Important safety information:

  • Enfuvirtide may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. Using Enfuvirtide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Enfuvirtide is not a cure for HIV infection and patients may continue to acquire illnesses and infections associated with HIV. Remain under the care of your doctor.
  • When your medicine supply begins to run low, get more from your doctor or pharmacist as soon as possible. The virus may develop resistance to Enfuvirtide and become more difficult to treat if you stop taking it, even for a short period of time.
  • Enfuvirtide offers no protection from the transmission of HIV to others through sexual contact or blood contamination. Use barrier forms of contraception (eg, condoms) if you are infected with HIV. Do not share needles, other injection equipment, or personal items, such as toothbrushes or razor blades.
  • LAB TESTS may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Enfuvirtide is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Enfuvirtide during pregnancy. HIV-infected mothers should not breast-feed their infants because of the risk of transmitting the HIV infection or Enfuvirtide .

Possible side effects of Enfuvirtide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; injection site reactions (pain, redness, itching, bleeding, bruising, hardened skin, or bumps); loss of appetite; muscle pain; nausea; sleeplessness; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; blood in the urine; depression; fever with vomiting and skin rash; flu-like symptoms; muscle pain; pneumonia; stomach pain; swelling of the feet.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Enfuvirtide :

Store powder at 77 degrees F (25 degrees C). Mixed solution should be stored in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), and used within 24 hours. Do not use after the expiration date on the vial. Keep Enfuvirtide out of the reach of children and away from pets.

General information:

  • If you have any questions about Enfuvirtide , please talk with your doctor, pharmacist, or other health care provider.
  • Enfuvirtide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Enfuvirtide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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