22 . January , 2018 - Monday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: entacapone

Big Image

Generic Name: entacapone (en TAH cah pone)
Brand Names: Comtan

What is entacapone?

When used with levodopa and carbidopa, entacapone increases levels of levodopa (Dopar, Larodopa, Sinemet) in the body.

Entacapone is used with carbidopa and levodopa to treat patients with Parkinson's disease who experience the signs and symptoms of end-of-dose "wearing-off". Entacapone is used only in combination with carbidopa and levodopa. It has no effect if it is used on its own.

Entacapone may also be used for purposes other than those listed in the medication guide.

What is the most important information I should know about entacapone?

Use caution when driving, operating machinery, or performing other hazardous activities. Entacapone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when rising from a sitting or lying position. To avoid falls, rise slowly from a sitting or lying position.

Hallucinations may occur with entacapone. Call your doctor if you experience hallucinations.

Who should not take entacapone?

Do not take entacapone without first talking to your doctor if you
  • have liver disease;
  • are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate); or

  • have ever experienced muscle damage or elevated body temperature and confusion because of a medication.

You may not be able to take entacapone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Entacapone is in the FDA pregnancy category C. This means that it is not known whether entacapone will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether entacapone passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take entacapone?

Take entacapone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Entacapone should always be taken with levodopa/carbidopa. Entacapone has no antiparkinsonian effect of its own.

Take entacapone with a full glass of water.

You can take entacapone with or without food.

Do not stop taking entacapone suddenly. You may require a gradual dosage reduction to prevent withdrawal effects. Store entacapone at room temperature in a tight container away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an entacapone overdose are not known.

What should I avoid while taking entacapone?

Use caution when driving, operating machinery, or performing other hazardous activities. Entacapone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. To avoid falls, rise slowly.

Avoid alcohol or use it with caution while taking entacapone. Alcohol may increase drowsiness while taking entacapone.

Entacapone side effects

If you experience any of the following serious side effects, stop taking entacapone and seek emergency medical attention or notify your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • fever and confusion;

  • muscle pain; or

  • hallucinations.

Other, less serious side effects may be more likely to occur. Notify your doctor if you experience

  • abnormal movements of the muscles;

  • nausea or vomiting;

  • discolored urine;

  • diarrhea;

  • abdominal pain;

  • dry mouth;

  • dizziness;

  • anxiety;

  • drowsiness;

  • increased sweating; or

  • shortness of breath.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect entacapone?

Do not take entacapone without first talking to your doctor if you are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate). These medicines should not be taken with entacapone.

Before taking entacapone, tell your doctor if you are taking

  • isoproterenol (Isuprel, Medihaler-Iso, Duo-Medihaler);

  • epinephrine (Epi-Pen, Ana-Guard, Bronkaid Mist, Primatene Mist Inhaler, others);

  • norepinephrine (Levophed Bitartrate);

  • dopamine (Intropin);

  • dobutamine (Dobutrex);

  • methyldopa (Aldomet);

  • isoetherine (Bronkosol, Bronkometer);

  • bitolterol (Tornalate)

  • probenecid (Benemid);

  • cholestyramine (Questran, Prevalite, Locholest);

  • erythromycin (Ery-Tab, E-Mycin, Eryc, PCE Dispertab, E.E.S., and others);

  • rifampin (Rimactane, Rifadin); or

  • ampicillin (Principen, Totacillin, Omnipen, and others).

You may not be able to take entacapone, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Entacapone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Drugs other than those listed here may also interact with entacapone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about entacapone written for health professionals that you may read.

What does my medication look like?

Entacapone is available with a prescription under the brand name Comtan. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Comtan 200 mg-oval, brownish-orange tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 2/13/04 4:08:11 PM.

Recent Drug Updates at DrugIndexOnline:





Akineton Akineton
Some commonly used brand names are: In the U.S.— Akineton 2 Artane 5 Artane Sequels 5 Cogentin 1 Kemadrin 4 Parsidol 3 Trihexane 5 Trihexy 5 In Canada— Akineton 2 Apo-Benztropine 1 Apo-Trihex 5 Artane 5 Artane Sequels 5 Cogentin 1 Kemadrin 4 Parsitan 3 PMS Benztropine 1 PMS Procyc more...

carbidopa carbidopa
Generic Name: carbidopa (kar bi DOE pa) Brand Names: Lodosyn What is carbidopa? Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease is believed to be related to low levels of a chemical called dopamine (DOE pa meen) in the brain. Levodopa (Dopar, Larodopa) i more...

Copper Supplements Copper Supplements
Some commonly used brand names are: In the U.S.— Cupri-Pak 2 Note: For quick reference, the following copper supplements are numbered to match the corresponding brand names. This information applies to the following: 1. Copper Gluconate (KOP-er GLOO-coh-nate)†‡ more...

Cubicin Cubicin
Generic Name: Daptomycin (DAP-toe-MYE-sin) Brand Name: CubicinCubicin is used for:Treating serious infections caused by certain bacteria. It may also be used for other conditions as determined by your doctor. Cubicin is an antibiotic. It works by killing sensitive bacteria. Do NOT use Cubicin more...

Dialume Dialume
Generic Name: aluminum hydroxide (ah LOO mih num hi DROCK side) Brand Names: Alternagel, Alu-Cap, Alu-Tab, Amphojel, Dialume What is Dialume (aluminum hydroxide)? Aluminum is a naturally occurring substance. Aluminum hydroxide is the hydroxide salt form of aluminum designed for oral ing more...

Doxil Doxil
Some commonly used brand names are: In the U.S.— Doxil In Canada— Caelyx Category Antineoplastic Description Liposomal doxorubicin (LIP-oh-som-al dox-oh-ROO-bi-sin) belongs to the general group of medicines known as antineoplastics. It is used to treat some kinds of cance more...

Dyclonine Dental Dyclonine Dental
Some commonly used brand names are: In the U.S.— Anbesol, Baby 1 Anbesol Maximum Strength Gel 1 Anbesol Maximum Strength Liquid 1 Anbesol Regular Strength Gel 3 Anbesol Regular Strength Liquid 3 Benzodent 1 Chloraseptic Lozenges 2 Chloraseptic Lozenges, Children's 1 Dentapaine 1 Dent-Zel- more...

Phenytoin Phenytoin
Generic Name: Phenytoin Injection (FEN-ih-toe-in) Brand Name: Generic only. No brands available.Phenytoin is to be injected slowly. Phenytoin is used for:Treating certain types of seizures and preventing and treating seizures during surgery of the nervous system. It may also be used for other c more...