24 . February , 2019 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Eplerenone

Big Image

Generic name: Eplerenone
Brand names: Inspra

Why is Eplerenone prescribed?

Inspra is prescribed to improve survival in patients who have congestive heart failure and left ventricular systolic dysfunction following a heart attack. It is also used to treat high blood pressure. Inspra may be used alone or with other antihypertensive agents. Inspra lowers blood pressure by blocking the actions of the hormone aldosterone.

Most important fact about Eplerenone

Inspra can increase the levels of potassium in your blood, resulting in a potentially serious condition called "hyperkalemia." Your doctor will order periodic blood tests to check the amount of potassium in your blood. Be sure to avoid potassium supplements and salt substitutes that contain potassium. Make sure your doctor knows about every medication you are taking. Call your doctor immediately if you experience nausea, diarrhea, or weakness, as these may be signs of hyperkalemia.

How should you take Eplerenone?

Take Inspra exactly as prescribed; higher-than-recommended doses provide no additional benefit. Inspra may be taken with or without food.

--If you miss a dose...

Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Inspra.

  • More common side effects may include:
    Chest pain, dizziness, headache, high cholesterol and triglyceride levels, increased blood potassium level, increased risk for heart attack, kidney problems

This side effects list is not complete. If you have any questions about side effects you should consult your doctor. Report any new or continuing symptoms to your doctor right away.

Why should Eplerenone not be prescribed?

If your doctor determines that you have high blood potassium levels or severe kidney impairment, you cannot take Inspra. You must also avoid Eplerenone if you are taking certain medications that affect the liver (see "Possible food and drug interactions when taking Eplerenone").

You cannot take Inspra for high blood pressure if you also take potassium-sparing diuretics such as amiloride (Moduretic), spironolactone (Aldactone), and triamterene (Dyazide, Dyrenium, Maxide). Likewise, Eplerenone cannot be used to treat high blood pressure if you have type 2 diabetes along with high protein levels in the urine (known as microalbuminuria), a condition that could signal kidney problems.

Special warnings about Eplerenone

Inspra could cause potentially dangerous increases of blood potassium levels. Your doctor will monitor you closely to guard against this problem, especially if you also have diabetes or mild kidney or liver problems.

Use Inspra with caution if you have severe liver impairment. The drug's safety has not been studied in such people.

In clinical studies, Inspra did not appear to benefit people 75 years and older who were being treated for congestive heart failure following a heart attack. However, when treated for high blood pressure, those 65 and older experienced the same benefits as younger people.

Possible food and drug interactions when taking Eplerenone

Be sure to check with your doctor about the medications that should never be taken with Inspra, including:

Clarithromycin (Biaxin)
Itraconazole (Sporanox)
Ketoconazole (Nizoral)
Nefazodone (Serzone)
Nelfinavir (Viracept)
Ritonavir (Norvir)
Troleandomycin (Tao)

You should never take Inspra for high blood pressure if you're also taking potassium-sparing diuretics, including:

Amiloride (Moduretic)
Spironolactone (Aldactone)
Triamterene (Dyazide, Dyrenium, Maxide)

If Inspra is taken with certain other drugs, the effects of either drug could be increased, decreased, or altered. It is especially important to check with your doctor before combining Inspra with the following:

Blood pressure drugs known as ACE inhibitors, such as Prinivil and Zestril
Blood pressure drugs known as angiotensin II receptor antagonists, such as Avapro, Cozaar, and Diovan
Erythromycin (Ery-Tab)
Fluconazole (Diflucan)
Lithium (Eskalith, Lithobid, Lithonate)
Nonsteroidal anti-inflammatory drugs such as Motrin or Advil
Potassium supplements including K-Tabs, K-Dur, and Slow-K
Saquinavir (Invirase)
Verapamil (Calan, Isoptin)

You should also consult your doctor before using salt substitutes that contain potassium.

Special information if you are pregnant or breastfeeding

The effects of Inspra during pregnancy have not been adequately studied. If you are pregnant or planning to become pregnant, inform your doctor immediately.

It is not known whether Inspra appears in human breast milk. If Eplerenone is essential to your health, your doctor may advise you to stop nursing until your treatment is finished.

Recommended dosage

ADULTS

Congestive heart failure after a heart attack

The recommended daily dose is 50 milligrams. Your doctor will start you at 25 milligrams once a day and gradually increase the dose to 50 milligrams once a day over a period of 4 weeks.

Your doctor will test your blood potassium levels during the first week of treatment and again after 1 month. Depending on the results, the doctor may change your dosage and continue monitoring your potassium levels.

High blood pressure

The recommended starting dose is 50 milligrams once a day. Based on your response, the doctor may increase the dose to a maximum of 50 milligrams twice a day. If you're taking certain drugs that affect the liver, the doctor may start you at a dose of 25 milligrams once a day.

Overdosage

No cases of overdose have been reported. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency treatment immediately.

  • The most likely symptoms of an Inspra overdose may include:
    Dizziness, diarrhea, feeling faint or light-headed, nausea, weakness

Recent Drug Updates at DrugIndexOnline:





Calmine Calmine
Some commonly used brand names are: In the U.S.— Acuprin 81 1 Amigesic 8 Anacin Caplets 2 Anacin Maximum Strength 2 Anacin Tablets 2 Anaflex 750 8 Arthritis Pain Ascriptin 3 Arthritis Pain Formula 3 Arthritis Strength Bufferin 3 Arthropan 5 Aspergum 1 Aspirin Regimen Bayer Adult Low Dose more...

Carbinoxamine Maleate Carbinoxamine Maleate
Generic Name: Carbinoxamine Maleate Tablets (kar-bi-NOX-a-meen) Brand Name: PalgicCarbinoxamine Maleate is used for:Treating allergy symptoms such as runny nose, watery/itchy eyes, rash, or hives. It may also be used for other conditions as determined by your doctor. Carbinoxamine Maleate is a more...

Cogentin Cogentin
Generic Name: benztropine (BENZ troe peen) Brand Names: Cogentin What is Cogentin (benztropine)? Benztropine reduces the effects of certain chemicals in the body that may become unbalanced as a result of disease (such as Parkinson's), drug therapy, or other causes. Benztropine is used t more...

Crotamiton Topical Crotamiton Topical
Some commonly used brand names are: In the U.S.— Eurax Cream Eurax Lotion In Canada— Eurax Cream Category Scabicide Description Crotamiton (kroe-TAM-i-tonn) is used to treat scabies infection. It is also used to relieve the itching of certain skin conditions. This medicin more...

doxazosin doxazosin
Generic Name: doxazosin (dox AY zo sin) Brand Names: Cardura, Cardura XL What is doxazosin? Doxazosin is in a group of drugs called alpha-adrenergic blockers. Doxazosin causes the blood vessels (veins and arteries) to relax and expand, improving blood flow. Doxazosin also relaxes muscle more...

Frova Frova
Generic Name: Frovatriptan (froe-va-TRIP-tan) Brand Name: FrovaFrova is used for:Treating acute migraine headache with or without aura (flashing lights, wavy lines, dark spots) in adults. It should not be used to prevent migraines. Frova is a triptan. It works by narrowing the blood vessels in more...

Gaviscon Gaviscon
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...

Lidocaine Gel Lidocaine Gel
Generic Name: Lidocaine Gel 0.5% (L Y E-doe-cane) Brand Name: Solarcaine Aloe ExtraLidocaine Gel is used for:Temporarily relieving pain and itching associated with minor cuts, skin scrapes, minor burns (including sunburn), minor skin irritation, and insect bites. Lidocaine Gel is an anesthetic. more...