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All about: Erythromycin ethylsuccinate, Sulfisoxazole acetyl

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Generic name: Erythromycin ethylsuccinate, Sulfisoxazole acetyl
Brand names: Eryzole, Pediazole

Why is Erythromycin ethylsuccinate, Sulfisoxazole acetyl prescribed?

Pediazole is prescribed for the treatment of severe middle ear infections in children.

Most important fact about Erythromycin ethylsuccinate, Sulfisoxazole acetyl

Sulfisoxazole is one of a group of drugs called sulfonamides, which prevent the growth of certain bacteria in the body. However, sulfonamides have been known to cause rare but sometimes fatal reactions such as Stevens-Johnson syndrome (a skin condition characterized by severe blisters and bleeding in the mucous membranes of the lips, mouth, nose, and eyes), sudden and severe liver damage, a severe blood disorder (agranulocytosis), and a lack of red and white blood cells because of a bone marrow disorder.

Notify your doctor at the first sign of a side effect such as skin rash, sore throat, fever, abnormal skin paleness, reddish or purplish skin spots, or yellowing of the skin or whites of the eyes.

How should you take Erythromycin ethylsuccinate, Sulfisoxazole acetyl?

Be sure to keep giving Pediazole for the full time prescribed, even if your child begins to feel better after the first few days. Keep to a regular schedule; the medication works best when there is a constant amount in the blood.

Pediazole can be given with or without food. However, you should not give Erythromycin ethylsuccinate, Sulfisoxazole acetyl with or immediately after carbonated beverages, fruit juice, or tea. If the child develops an upset stomach, give the medicine with crackers or a light snack.

To prevent sediment in the urine and the formation of stones, make sure that the child drinks plenty of fluids during treatment with Pediazole.

This medication increases the skin's sensitivity to sunlight. Overexposure can cause a rash, itching, redness, or sunburn. Keep the child out of direct sunlight, or provide protective clothing.

Shake well before using.

--If you miss a dose...

Give the forgotten dose as soon as you remember, then give the rest of the day's doses at evenly spaced intervals.

--Storage instructions...

Store Pediazole in the refrigerator. Keep tightly closed. Do not allow it to freeze. Use within 14 days; discard unused portion.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe to continue giving Pediazole.

  • More common side effects may include:
    Abdominal pain and discomfort, diarrhea, lack or loss of appetite, nausea, vomiting

Why should Erythromycin ethylsuccinate, Sulfisoxazole acetyl not be prescribed?

If your child is sensitive to or has ever had an allergic reaction to erythromycin, sulfonamides, or other drugs of this type, do not use Erythromycin ethylsuccinate, Sulfisoxazole acetyl. Make sure that your doctor is aware of any drug reactions that your child has experienced.

Pediazole should not be used if the child is taking Seldane or Hismanal.

This medication should not be prescribed for infants under 2 months of age.

Pediazole should not be taken by pregnant women at the end of their pregnancy or by mothers nursing infants under 2 months of age.

Special warnings about Erythromycin ethylsuccinate, Sulfisoxazole acetyl

If your child has impaired kidney or liver function or a history of severe allergies or bronchial asthma, Pediazole may not be the best drug to use. Check with your doctor.

Prolonged or repeated use of Pediazole may cause new infections. If your child develops a new infection (called a superinfection), talk to your doctor. A different antibiotic may be needed.

If your child develops a cough or becomes short of breath, call your doctor. Also seek care immediately if the child develops diarrhea; it could signal a serious intestinal disorder.

If your child has the muscle-weakening disorder myasthenia gravis, Pediazole could make the condition worse.

Your doctor may recommend frequent urine tests while your child is taking Pediazole.

Possible food and drug interactions when taking Erythromycin ethylsuccinate, Sulfisoxazole acetyl

If Pediazole is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Pediazole with the following:

Blood thinners such as warfarin (Coumadin)
Bromocriptine (Parlodel)
Carbamazepine (Tegretol)
Cyclosporine (Sandimmune)
Digoxin (Lanoxin)
Disopyramide (Norpace)
Ergotamine (Cafergot, Ergostat)
Lovastatin (Mevacor)
Methotrexate (Rheumatrex)
Oral antidiabetic drugs such as Micronase
Phenytoin (Dilantin)
Theophylline (Theo-Dur)
Triazolam (Halcion)

Special information if you are pregnant or breastfeeding

This drug is not prescribed for adults, and should never be taken at term of pregnancy or when breastfeeding.

Recommended dosage


The recommended dose for children 2 months of age or older is determined by weight. The total daily amount is divided into several smaller doses given 3 or 4 times a day for 10 days.

Four-times-a-day schedule:

Less than 18 pounds: Determined by doctor
18 pounds: 1/2 teaspoonful
35 pounds: 1 teaspoonful
53 pounds: 1-1/2 teaspoonfuls
Over 70 pounds: 2 teaspoonfuls

Three-times-a-day schedule:

Less than 13 pounds: Determined by doctor
13 pounds: 1/2 teaspoonful
26 pounds: 1 teaspoonful
40 pounds: 1-1/2 teaspoonfuls
53 pounds: 2 teaspoonfuls
Over 66 pounds: 2-1/2 teaspoonfuls


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

  • Symptoms of Pediazole overdose may include:
    Blood in the urine, colic, dizziness, drowsiness, fever, headache, loss of appetite, nausea, unconsciousness, vomiting, yellowed eyes and skin

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