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All about: Amiloride, Hydrochlorothiazide

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Generic name: Amiloride, Hydrochlorothiazide
Brand names: Moduretic

Why is Amiloride, Hydrochlorothiazide prescribed?

Moduretic is a diuretic combination used in the treatment of high blood pressure and congestive heart failure, conditions which require the elimination of excess fluid (water) from the body. When used for high blood pressure, Moduretic can be used alone or with other high blood pressure medications. Diuretics help your body produce and eliminate more urine, which helps lower blood pressure. Amiloride, one of the ingredients, helps minimize the potassium loss that can be caused by the other component, hydrochlorothiazide.

Most important fact about Amiloride, Hydrochlorothiazide

If you have high blood pressure, you must take Moduretic regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Moduretic; and you must continue taking it even if you are feeling well. Moduretic does not cure high blood pressure; it merely keeps it under control.

How should you take Amiloride, Hydrochlorothiazide?

Take Amiloride, Hydrochlorothiazide with food.

Take Moduretic exactly as prescribed by your doctor. Stopping Moduretic suddenly could cause your condition to worsen.

--If you miss a dose...

Take the forgotten dose as soon as you remember. If it is almost time for your next does, skip the one you missed and go back to your regular schedule. Never take a double dose.

--Storage instructions...

Store at room temperature. Keep Amiloride, Hydrochlorothiazide in the container it came in, tightly closed, and protected from moisture, light, and freezing.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Moduretic.

  • More common side effects may include:
    Diarrhea, dizziness, elevated potassium levels, fatigue, headache, irregular heartbeat, itching, leg pain, loss of appetite, nausea, rash, shortness of breath, stomach and intestinal pain, weakness

Why should Amiloride, Hydrochlorothiazide not be prescribed?

If you are unable to urinate or have serious kidney disease, or if you have high potassium levels in your blood, you should not take Amiloride, Hydrochlorothiazide.

If you are sensitive to or have ever had an allergic reaction to amiloride, hydrochlorothiazide or similar drugs, or if you are sensitive to other sulfonamide-derived drugs, you should not take Amiloride, Hydrochlorothiazide. Make sure your doctor is aware of any drug reactions you may have experienced.

Special warnings about Amiloride, Hydrochlorothiazide

Potassium supplements, potassium-containing salt substitutes, and other diuretics (such as Dyazide) that minimize loss of potassium should not be used while you are taking moduretic unless your doctor specifically says otherwise. You should also limit your consumption of potassium-rich foods such as bananas, prunes, raisins, orange juice, and whole and skim milk. Ask your doctor for advice on how much of these foods to consume.

If you are taking Moduretic, a complete assessment of your kidney function should be done; kidney function should continue to be monitored.

If you are taking an ACE-inhibitor type of blood pressure medication such as Vasotec, Amiloride, Hydrochlorothiazide should be used with extreme caution.

If you have liver disease, diabetes, gout, or collagen vascular disease (lupus erythematosus), Moduretic should be used with caution.

If you have bronchial asthma or a history of allergies, you may be at risk for an allergic reaction to Amiloride, Hydrochlorothiazide.

Dehydration, excessive sweating, severe diarrhea or vomiting could deplete your fluids and cause your blood pressure to become too low. Be careful when exercising and in hot weather.

Notify your doctor or dentist that you are taking Moduretic if you have a medical emergency or before you have surgery.

Possible food and drug interactions when taking Amiloride, Hydrochlorothiazide

Moduretic may increase the effects of alcohol. Avoid alcohol while taking Amiloride, Hydrochlorothiazide.

If Moduretic is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Moduretic with the following:

ACE inhibitors such as Vasotec
Barbiturates such as phenobarbital
Cholestyramine (Questran)
Colestipol (Colestid)
Corticosteroids such as prednisone
Cyclosporine (Sandimmune, Neoral)
Insulin
Lithium (Eskalith, Lithobid)
Muscle relaxants such as tubocurarine
Narcotics such as Percocet
Nonsteroidal anti-inflammatory drugs such as Naprosyn
Norepinephrine (Levophed)
Oral drugs for treating diabetes such as Micronase, DiaBeta
Other high blood pressure medications
Tacrolimus (Prograf)

Special information if you are pregnant or breastfeeding

The effects of Moduretic during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Moduretic appears in breast milk and could affect a nursing infant. If Amiloride, Hydrochlorothiazide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage

Your doctor will tailor the dosage to meet your individual requirements, taking into consideration other medical conditions you may have and other medications you may be taking.

ADULTS

The usual starting dose is 1 tablet per day, which may be increased to 2 tablets per day taken at the same time or separately.

CHILDREN

The safety and effectiveness of Moduretic have not been established in children.

Overdosage

Any medication taken in excess can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately.

No specific information on symptoms of Moduretic overdose is available, but dehydration might be expected.

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