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All about: Lithium Syrup

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Generic Name: Lithium Syrup and Oral Solution (LITH-ee-um)
Brand Name: Generic only. No brands available.

Symptoms of toxicity may sometimes occur even with normal doses of Lithium Syrup. Do not exceed the recommended dose. Your doctor should monitor your blood lithium levels routinely to help prevent lithium toxicity. Contact your doctor immediately if you experience symptoms of toxicity such as nausea, diarrhea, vomiting, blurred vision, ringing in the ears, drowsiness, giddiness, muscle weakness, tremor, twitching, seizures, loss of consciousness, loss of coordination, or increased urination.


Lithium Syrup is used for:

Treating manic episodes in patients with bipolar disorder. It is also used to reduce the frequency and decrease the severity of manic episodes in patients with bipolar disorder. It may also be used for other conditions as determined by your doctor.

Lithium Syrup is an antimanic agent. Exactly how Lithium Syrup works is unknown, but it may work by altering the balance of certain chemicals in the brain.

Do NOT use Lithium Syrup if:

  • you are allergic to any ingredient in Lithium Syrup
  • you have moderate to severe kidney, heart, or blood vessel problems
  • you have low blood sodium levels
  • you are severely dehydrated, ill, or weakened
  • you are taking an angiotensin-converting enzyme (ACE) inhibitor (eg, enalapril) or a diuretic (eg, furosemide, hydrochlorothiazide)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lithium Syrup:

Some medical conditions may interact with Lithium Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diarrhea, vomiting, excessive sweating, dehydration, fever, infection, or illness, or you are in a weakened state
  • if you have kidney, heart, blood vessel, or thyroid problems
  • if you have brain or nerve problems (eg, organic brain syndrome)
  • if you are on a low-salt diet

Some MEDICINES MAY INTERACT with Lithium Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Acetazolamide, urea, urinary alkalinizers (eg, sodium bicarbonate), or xanthines (eg, theophylline) because they may decrease Lithium Syrup's effectiveness
  • ACE inhibitors (eg, enalapril), angiotensin II receptor antagonists (eg, losartan), calcium channel blockers (eg, verapamil), carbamazepine, diuretics (eg, furosemide, hydrochlorothiazide), hydantoins (eg, phenytoin), methyldopa, metronidazole, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin, celecoxib), or selective serotonin reuptake inhibitor (SSRI) antidepressants (eg, fluoxetine) because the risk of toxicity of Lithium Syrup may be increased
  • Butyrophenones (eg, haloperidol) or other medicines for mental or mood problems because the risk of serious side effects, such as confusion, involuntary muscle movements, fever, and brain damage, may be increased
  • Iodide preparations (eg, potassium iodide) because the risk of low thyroid levels may be increased
  • Nondepolarizing neuromuscular blockers (eg, vecuronium) or succinylcholine because the risk of their side effects may be increased by Lithium Syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lithium Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lithium Syrup:

Use Lithium Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lithium Syrup by mouth after meals or with food or milk to decrease stomach upset.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Drinking extra fluids while you are taking Lithium Syrup is recommended. Check with your doctor for instructions.
  • Do not change your diet, including the amount of salt in your diet, unless instructed by your doctor.
  • If you miss a dose of Lithium Syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lithium Syrup.

Important safety information:

  • Lithium Syrup may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Lithium Syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • It may take 1 to 3 weeks for Lithium Syrup to work. Do not stop using Lithium Syrup without checking with your doctor.
  • Tell your doctor or dentist that you take Lithium Syrup before you receive any medical or dental care, emergency care, or surgery.
  • Fever, infection, vomiting, diarrhea, or excessive sweating may affect the levels of Lithium Syrup in your blood. If you experience any of these conditions, contact your doctor. Talk to your doctor about how to replace the salt lost through sweating during exercise.
  • Do not change the amount of salt in your diet unless instructed by your doctor. Check with your doctor before restricting your salt intake. Tell your doctor if you are on a low-salt diet.
  • Lab tests, including blood lithium levels and kidney function tests, may be performed while you use Lithium Syrup. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Lithium Syrup with caution in the ELDERLY; they may be more sensitive to its effects.
  • Lithium Syrup should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Lithium Syrup may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lithium Syrup while you are pregnant. Lithium Syrup is found in breast milk. Do not breast-feed while taking Lithium Syrup.

Possible side effects of Lithium Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild hand tremor; mild thirst; temporary, mild nausea and general discomfort at the beginning of treatment.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; confusion; diarrhea; drowsiness; excessive weight gain; fainting; giddiness; inability to control the bladder or bowels; increased thirst; increased or decreased urination; involuntary twitching or muscle movements; loss of consciousness; loss of coordination; muscle weakness; persistent headache; persistent or severe nausea; ringing in the ears; seizures; slow or irregular heartbeat; slurred speech; swelling of the ankles or wrists; unsteadiness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; diarrhea; drowsiness; giddiness; increased urination; loss of consciousness; loss of coordination; muscle weakness; nausea; ringing in the ears; seizures; tremor; twitching; vomiting.

Proper storage of Lithium Syrup:

Store Lithium Syrup at 77 degrees F (25 degrees C) in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, light, and moisture. Keep Lithium Syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about Lithium Syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Lithium Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lithium Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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