18 . February , 2019 - Monday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Lomustine

Big Image Pronouncation: (LOW-muss-teen)
Class: Nitrosoureas

Trade Names:
- Capsules 10 mg
- Capsules 40 mg
- Capsules 100 mg

Mechanism of Action


Its mechanism of action involves the inhibition of both DNA and RNA synthesis through DNA alkylation. Lomustine has been shown to affect a number of cellular processes including RNA, protein synthesis, and the processing of ribosomal and nucleoplasmic messenger RNA; DNA base component structure; the rate of DNA synthesis and DNA polymerase activity. It is cell cycle nonspecific.



Bioavailability is 100%.


Vd is 3.25 L/kg. High lipid solubility; crosses blood-brain barrier readily. Levels of radioactivity in the CSF are at least 50% of those in plasma.


Readily degraded, apparently in the liver, to several cytotoxic metabolites.


Plasma t ½ of the metabolites is about 16 h to 2 days. The average terminal t ½ is 22 min. Cl is 56 mL/min/kg. 60% to 70% of the total dose is excreted in the urine in 96 h and 6% is expired as CO 2 .

Indications and Usage

Adults and children

Brain tumors, Hodgkin disease.


Standard considerations.

Dosage and Administration

Brain Tumors, Hodgkin Disease

PO 100 to 130 mg/m 2 administered as a single dose every 6 wk. Do not administer repeat doses of lomustine until leukocyte and platelet counts have recovered to acceptable levels (usually 4,000/mm 3 and 100,000/mm 3 , respectively). Reduce lomustine dose if administered with other myelosuppressive drugs. Give 100 mg/m 2 to patients with compromised bone marrow function. Some clinicians advocate dosage reductions of 25% when platelet nadirs are 50,000 to 74,999/mm 3 , 50% when platelet nadirs are 25,000 to 49,999/mm 3 , and 75% when platelet nadirs are less than 25,000/mm 3 .


PO 75 to 150 mg/m 2 administered as a single dose every 6 wk. Do not administer repeat doses of lomustine until leukocyte and platelet counts have recovered to acceptable levels (usually 4,000/mm 3 and 100,000/mm 3 , respectively). Follow dosage adjustment guidelines recommended for adults.

Suggested Lomustine Dose Following Initial Dose

PO Give 100% of the prior dose if the leukocytes are greater than 3,000 cells/mm 3 and the platelets are greater than 75,000 cells/mm 3 . Give 70% of the prior dose if the leukocytes are 2,000 to 2,999 cells/mm 3 and the platelets are 25,000 to 74,999 cells/mm 3 . Give 50% of the prior dose if the leukocytes are less than 2,000 cells/mm 3 and the platelets less than 25,000 cells/mm.

General Advice

  • Administer orally. Take lomustine on an empty stomach to reduce nausea.
  • Nausea and vomiting may occur 3 to 6 h after an oral dose and usually last less than 24 h. Antiemetics prior to dosing may diminish and sometimes prevent these effects. Also may be reduced by administration to fasting patients.


Store in well-closed containers at room temperature. Avoid excessive heat (greater than 104°F).

Drug Interactions


Lomustine is soluble in alcohol. Some sources recommend avoidance of alcohol on days that lomustine is administered to avoid possible effects on the absorption of lomustine, although there is no documentation of an interaction.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Disorientation; lethargy; ataxia; slurred speech.


Very high potential for nausea and vomiting with doses at least 60 mg/m 2 , moderate to high potential for nausea and vomiting with doses less than 60 mg/m 2 ; anorexia; transient elevation of LFTs.


Bone marrow suppression, nadir at 4 to 6 wk.


Renal failure associated with large cumulative dose.


Acute leukemia and myelodysplastic disorders have occurred after long-term nitrosourea therapy.




The most frequent and serious toxicity is delayed myelosuppression. It usually occurs 4 to 6 wk after drug administration and is dose-related. Thrombocytopenia occurs approximately 4 wk after a dose. Leukopenia occurs approximately 5 to 6 wk after a dose and persists for 1 to 2 wk. About 65% of patients develop WBC less than 5,000/mm 3 , and 36% of patients develop WBC less than 3,000/mm 3 . Thrombocytopenia is generally more severe than leukopenia. Anemia also occurs but is less frequent.


Blood counts

Monitor blood counts weekly for 6 wk after a dose. Monitor liver and renal function periodically.

Baseline pulmonary function tests

Conduct baseline pulmonary function studies during treatment. Patients with a baseline less than 70% of the predicted forced vital capacity (FVC) or carbon monoxide diffusing capacity (DL CO ) are particularly at risk.


Category D .




See Route/Dosage.


There have been reports of persistent testicular damage causing infertility.

Hepatic toxicity

A reversible type of hepatic toxicity manifested by increased transaminase, alkaline phosphatase, and bilirubin levels has occurred in a small percentage of patients.

Renal toxicity

Decreased kidney size, progressive azotemia, and renal failure have occurred in patients who received large cumulative doses after prolonged therapy.

Pulmonary toxicity

Pulmonary toxicity characterized by pulmonary infiltrates or fibrosis occurs rarely and appears to be dose-related. Onset of toxicity has occurred after an interval of at least 6 mo from start of therapy with cumulative doses usually greater than 1100 mg/m 2 .

Secondary malignancies

Long-term use of nitrosoureas may be associated with development of secondary malignancies.

Patient Information

  • Notify health care provider if fever, chills, sore throat, unusual bleeding or bruising, shortness of breath, dry cough, swelling of feet or lower legs, yellowing of eyes and skin, confusion, sores on the mouth or lips, or unusual tiredness occurs.
  • Medication may cause loss of appetite; nausea; vomiting; hair loss; skin rash or itching (infrequent); notify health care provider if these reactions become pronounced.
  • Take on an empty stomach to reduce nausea.
  • Avoid alcohol for short periods after taking a dose of lomustine.
  • Contraceptive measures are recommended during therapy.

Recent Drug Updates at DrugIndexOnline:

Cefixime Cefixime
Some commonly used brand names are: In the U.S.— Ancef 4 Ceclor 1 Ceclor CD 1 Cedax 17 Cefadyl 23 Cefditoren 8 Cefizox 18 Cefobid 10 Cefotan 12 Ceftin 20 Cefzil 15 Ceptaz 16 Claforan 11 Duricef 2 Fortaz 16 Keflex 21 Keftab 21 Kefurox 20 Kefzol 4 Mandol 3 Maxipime 6 Mefoxin 13 Monocid 9 Om more...

Cyproheptadine Tablets Cyproheptadine Tablets
Generic Name: Cyproheptadine hydrochloride Dosage Form: Tablets Cyproheptadine Description Cyproheptadine HCl is an antihistaminic and antiserotonergic agent. Cyproheptadine hydrochloride is a white to slightly yellowish, crystalline solid, which is soluble in water, freely soluble in methanol, more...

Dextromethorphan/Phenylephrine/Pyrilamine Suspension Dextromethorphan/Phenylephrine/Pyrilamine Suspension
Generic Name: Dextromethorphan/Phenylephrine/Pyrilamine Suspension (dex-troe-meth-OR-fan/fen-ill-EF-rin/peer-IL-a-meen) Brand Name: Examples include Tannate-V-DM and Viravan DMDextromethorphan/Phenylephrine/Pyrilamine Suspension is used for:Relieving symptoms of sinus congestion, runny nose, sn more...

Epistatin Epistatin
Some commonly used brand names are: In the U.S.— Altoprev 4 Lescol 3 Lipitor 1 Mevacor 4 Pravachol 5 Zocor 6 Note: Baycol was removed from the U.S. market by Bayer in August 2001. In Canada— Lescol 3 Mevacor 4 Pravachol 5 Zocor 6 Other commonly used names are: Epistati more...

Mycelex-7 Cream Mycelex-7 Cream
Generic Name: Clotrimazole Vaginal Cream (7 Day) (kloe-TRIM-a-zole) Brand Name: Examples include Gyne-Lotrimin and Mycelex-7Mycelex-7 Cream is used for:Treating vaginal yeast infections and relieving external itching and irritation caused by yeast infections. Mycelex-7 Cream is an antifungal ag more...

Obephen Obephen
Generic Name: phentermine (FEN ter meen) Brand Names: Adipex-P, Fastin, Ionamin, Obenix, Obephen, Oby-Cap, Oby-Trim, Panshape M, Phentercot, Phentride, Pro-Fast HS, Pro-Fast SA, Pro-Fast SR, Teramine, Zantryl What is Obephen (phentermine)? Phentermine is a stimulant that is similar to a more...

Prednisolone/Sulfacetamide Suspension Prednisolone/Sulfacetamide Suspension
Generic Name: Prednisolone/Sulfacetamide Ophthalmic Suspension (pred-NISS-oh-lone/sul-fa-SEE-ta-mide) Brand Name: BlephamidePrednisolone/Sulfacetamide Suspension is used for:Treating inflammation (swelling, warmth, redness, pain) of the eyes and eyelids when infection or risk of infection is pre more...

Generic Name: lansoprazole and naproxen (lan SOE pra zole and na PROX en) Brand Names: PREVACID NapraPAC 375, PREVACID NapraPAC 500 What is PREVACID NapraPAC 375 (lansoprazole and naproxen)? Naproxen is in a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs). It wo more...