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All about: Losartan/Hydrochlorothiazide

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Generic Name: Losartan/Hydrochlorothiazide (loe-SAR-tan/HYE-droe-KLOR-oh-THYE-a-zide)
Brand Name: Hyzaar

Losartan/Hydrochlorothiazide can cause injury or even death to a developing fetus when used after the third month of pregnancy. Contact your doctor immediately if you suspect that you are pregnant.


Losartan/Hydrochlorothiazide is used for:

Treating high blood pressure. It may be used to decrease the risk of stroke in certain patients with high blood pressure. It may also be used for other conditions as determined by your doctor.

Losartan/Hydrochlorothiazide is a combination angiotensin II receptor blocker and diuretic. The angiotensin II receptor blocker works by relaxing the blood vessels. Exactly how the diuretic works to decrease blood pressure is unknown, but it helps the kidneys to eliminate fluid and sodium from the body.

Do NOT use Losartan/Hydrochlorothiazide if:

  • you are allergic to any ingredient in Losartan/Hydrochlorothiazide or to any other sulfonamide medicine (eg, sulfamethoxazole)
  • you are pregnant
  • you have severe liver or kidney problems or are unable to urinate
  • you are taking dofetilide or ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Losartan/Hydrochlorothiazide :

Some medical conditions may interact with Losartan/Hydrochlorothiazide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe reaction (eg, swelling of the hands, face, lips, eyes, throat, or tongue; trouble swallowing or breathing; hoarseness) after taking any other angiotensin II receptor blocker or an angiotensin converting enzyme (ACE) inhibitor (eg, captopril)
  • if you are dehydrated; have low blood volume; have low blood sodium, chloride, potassium, or magnesium levels; or have high blood calcium levels
  • if you have asthma; diabetes; gout; heart problems (eg, congestive heart failure); liver, gallbladder, or kidney problems; high blood cholesterol or lipid levels; or systemic lupus erythematosus
  • if you have recently had nerve surgery

Some MEDICINES MAY INTERACT with Losartan/Hydrochlorothiazide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Dofetilide or ketanserin because the risk of irregular heartbeat may be increased
  • Adrenocorticotropic hormone (ACTH), barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), diuretics (eg, furosemide), narcotic pain medicines (eg, morphine), or other medicines for high blood pressure because they may increase the risk of Losartan/Hydrochlorothiazide 's side effects
  • Cholestyramine, colestipol, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib) because they may decrease Losartan/Hydrochlorothiazide 's effectiveness
  • Diazoxide, digoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), potassium, or potassium-sparing diuretics (eg, spironolactone) because risk of their side effects and toxic effects may be increased by Losartan/Hydrochlorothiazide
  • Diabetes medicine (eg, glipizide, metformin), insulin, or pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Losartan/Hydrochlorothiazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Losartan/Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Losartan/Hydrochlorothiazide :

Use Losartan/Hydrochlorothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Losartan/Hydrochlorothiazide . Talk to your pharmacist if you have questions about this information.
  • Take Losartan/Hydrochlorothiazide by mouth with or without food.
  • Drinking extra fluids while you are taking Losartan/Hydrochlorothiazide is recommended. Check with your doctor for instructions.
  • Losartan/Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Losartan/Hydrochlorothiazide .
  • Continue to take Losartan/Hydrochlorothiazide even if you feel well. Do not miss any doses.
  • If you miss a dose of Losartan/Hydrochlorothiazide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Losartan/Hydrochlorothiazide .

Important safety information:

  • Losartan/Hydrochlorothiazide may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Losartan/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Losartan/Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Report any lightheadedness or fainting to your doctor immediately. Your risk of lightheadedness or fainting may be increased if you experience diarrhea, vomiting, excessive sweating, if you do not drink enough fluids, or if you are on a low-salt diet.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel пїЅ"normal."пїЅ Tell your doctor if you develop any new symptoms.
  • Losartan/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Losartan/Hydrochlorothiazide . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Losartan/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Diabetes patients - Losartan/Hydrochlorothiazide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Losartan/Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Losartan/Hydrochlorothiazide has not been shown to reduce the risk of stroke or certain heart problems in black patients who have high blood pressure.
  • Losartan/Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Losartan/Hydrochlorothiazide .
  • Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Losartan/Hydrochlorothiazide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Losartan/Hydrochlorothiazide with caution in the ELDERLY; they may be more sensitive to its effects.
  • Losartan/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Losartan/Hydrochlorothiazide may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Losartan/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Losartan/Hydrochlorothiazide .

Possible side effects of Losartan/Hydrochlorothiazide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; diarrhea; dizziness; lightheadedness, especially when sitting up or standing; nausea; numbness or tingling of the skin; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decrease in sexual ability; decreased urination; depression; drowsiness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; hoarseness; muscle pain, tenderness, or cramps; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent dry mouth; shortness of breath; swelling of the arms or legs; unusual bruising or bleeding; unusual thirst; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; fainting; fast, slow, or irregular heartbeat; severe or unusual dizziness.

Proper storage of Losartan/Hydrochlorothiazide :

Store Losartan/Hydrochlorothiazide at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Losartan/Hydrochlorothiazide out of the reach of children and away from pets.

General information:

  • If you have any questions about Losartan/Hydrochlorothiazide , please talk with your doctor, pharmacist, or other health care provider.
  • Losartan/Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Losartan/Hydrochlorothiazide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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