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All about: Moxifloxacin Tablets

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Generic Name: Moxifloxacin Tablets (mox-ee-FLOCKS-ah-sin)
Brand Name: Avelox

Moxifloxacin is used for:

Treating infections caused by certain bacteria.

Moxifloxacin is a fluoroquinolone that kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Do NOT use Moxifloxacin if:

  • you are allergic to any ingredient in Moxifloxacin or to other quinolone antibiotics (eg, levofloxacin)
  • you have an irregular heartbeat or low blood potassium levels
  • you are taking cisapride, a class IA or III antiarrhythmic (eg, quinidine, procainamide, amiodarone, sotalol), an H1 antagonist (eg, diphenhydramine), a phenothiazine (eg, thioridazine), or a tricyclic antidepressant (eg, amitriptyline)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Moxifloxacin:

Some medical conditions may interact with Moxifloxacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have Alzheimer disease, a central nervous system disease, hardening of the arteries in your brain, diarrhea, a stomach infection, recent low blood potassium levels, increased pressure in your head, liver problems or disease, seizures, or a personal or family history of heart problems or slow heart rate
  • if you are taking a corticosteroid (eg, prednisone)

Some MEDICINES MAY INTERACT with Moxifloxacin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aluminum salts or zinc salts because they may decrease Moxifloxacin's effectiveness
  • Arsenic, cisapride, dofetilide, droperidol, foscarnet, H1 antagonists (eg, diphenhydramine), class IA antiarrhythmics (eg, quinidine, procainamide), class IC antiarrhythmics (eg, flecainide, propafenone), class III antiarrhythmics (eg, amiodarone, sotalol), imidazoles (eg, ketoconazole), macrolides and ketolides (eg, erythromycin, azithromycin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenothiazines (eg, thioridazine), pimozide, procainamide, serotonin receptor antagonist antiemetics (eg, ondansetron), tramadol, tricyclic antidepressants (eg, amitriptyline), warfarin, or ziprasidone because the actions and side effects of either medicine may be increased, possibly leading to abnormal heart rhythms
  • Risperidone because heart problems may occur
  • Live oral typhoid vaccine because it may decrease Moxifloxacin's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Moxifloxacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Moxifloxacin:

Use Moxifloxacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Moxifloxacin. Talk to your pharmacist if you have questions about this information.
  • Take Moxifloxacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Drink plenty of liquids while taking Moxifloxacin.
  • Do not take any medicine that has magnesium or aluminum in it within 4 hours before or 8 hours after taking Moxifloxacin.
  • Use Moxifloxacin on a regular schedule to get the most benefit from it.
  • To clear up your infection completely, continue taking Moxifloxacin for the full course of treatment even if you begin to feel better in a few days. Do not miss any doses.
  • If you miss a dose of Moxifloxacin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Moxifloxacin.

Important safety information:

  • Moxifloxacin may cause dizziness, drowsiness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Moxifloxacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Be sure to use Moxifloxacin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Moxifloxacin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Moxifloxacin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Moxifloxacin only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Long-term or repeated use of Moxifloxacin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Moxifloxacin has infrequently caused tendon problems, including tendon rupture. If you experience any unusual pain or swelling in your joints (eg, shoulder, elbow, hand, hip, knee, ankle, foot), contact your doctor immediately. Rest and avoid exercise or other physically stressful activity until your doctor tells you otherwise.
  • Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Moxifloxacin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Moxifloxacin with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they are also taking corticosteroids (eg, prednisone).
  • Moxifloxacin should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Moxifloxacin can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Moxifloxacin while you are pregnant. It is unknown if Moxifloxacin is excreted in breast milk. Do not breast-feed while taking Moxifloxacin.

Possible side effects of Moxifloxacin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; convulsions; dark urine; decreased urination; depression; fainting; hallucinations; irregular heartbeats; joint or muscle pain; mental or mood changes; tendon pain or swelling; nerve pain; numbness or tingling of the skin; pneumonia; pounding in the chest; seizures; severe diarrhea; stomach pain/cramps; suicidal thoughts; tremor; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; drowsiness; facial swelling or numbness; hot and cold flushes; mild to moderate disorientation; nausea; slurring of speech.

Proper storage of Moxifloxacin:

Store Moxifloxacin at 77 degrees F (25 degrees C) in a tightly closed container. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not refrigerate. Do not store in the bathroom. Keep Moxifloxacin out of the reach of children and away from pets.

General information:

  • If you have any questions about Moxifloxacin, please talk with your doctor, pharmacist, or other health care provider.
  • Moxifloxacin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Moxifloxacin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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